Laminin Receptors in Peripheral Tissues --- Functions Revealed by Analysis of Knockout Mice [0.03%]
层粘连蛋白受体在外周组织中的功能敲除小鼠的研究
Wanling Xuan,Yao Yao
Wanling Xuan
Laminin, by interacting with its receptors---mainly integrins and dystroglycan, exerts a variety of important functions in multiple organs. Loss-of-function studies have demonstrated the essential roles of laminin receptors in both physiolo...
From Theory to Practice: A Comprehensive Review of Pseudomyxoma peritonei Research and its Implications for Future Treatment [0.03%]
从理论到实践：伪黏液瘤的综合研究及其对未来治疗的意义综述
Han Gao,Hongli Wang,Xiufeng Li et al.
Han Gao et al.
Pseudomyxoma peritonei (PMP) is a rare disease characterized by symptoms such as mucinous ascites and omental cake, typically arising from a perforated epithelial tumour of appendix. Due to its rarity, non-specific histological characterist...
Aldehyde dehydrogenase 2 deficiency impairs liver progenitor cell proliferation in alcohol-fed mice [0.03%]
丙醛脱氢酶2缺陷影响酒精喂养小鼠肝前体细胞增殖
Peng Xiao,Siting Yang,Shenghua Bi et al.
Peng Xiao et al.
Aldehyde dehydrogenase 2 (ALDH2) is a critical enzyme involved in the detoxification of acetaldehyde. Although numerous studies have demonstrated the significance of ALDH2 in alcohol-associated liver disease (ALD), its role in alcohol-induc...
Novel Perineural Pathways and The Dynamics of Simian Immunodeficiency Virus-Infected Macrophage Trafficking Out of the Central Nervous System [0.03%]
新型神经途径和毛猿免疫缺陷病毒感染的小胶质细胞从中枢神经系统移出的动力学规律
Zoey K Wallis,Yingshan Wei,Lily M Ceraso et al.
Zoey K Wallis et al.
A challenge to eradicate HIV is the CNS reservoir and unknown mechanisms-pathways by which infected macrophages can exit. We used intracisternal (i.c.) injection of superparamagnetic iron oxide nanoparticles (SPION) some of which had differ...
The Sugar-coated truth of alcohol-associated liver disease: Galectins as multi-faceted regulators of Alcohol-induced liver injury [0.03%]
糖衣下的真相：岩藻糖结合 lectin 在酒精性肝病中的作用
Doug Terry,Brian Robinson
Doug Terry
Alcohol-associated diver disease is a major driver of end-stage liver diseases globally. Alcohol functions as a hepatotoxin by overwhelming cell stress response pathways and deregulating hepatocellular protein, amino acid, and lipid metabol...
Delia Y Omar,Mathilda M Willoughby,Nourhan Mostafa et al.
Delia Y Omar et al.
Alcohol-associated liver disease (ALD) poses a significant global health burden, with alcoholic steatohepatitis (ASH) representing a severe subtype driven by chronic alcohol consumption, hepatic inflammation, and limited treatment options. ...
The Proteostasis Network in Proteinopathies: Mechanisms and Interconnections [0.03%]
蛋白质病中的蛋白质稳态网络：机制与相互作用
Dariusz Pytel,Jody Fromm Longo
Dariusz Pytel
Proteinopathies are neurodegenerative disorders that are characterized by accumulation of misfolded toxic protein aggregates that lead to synaptic and neuronal dysfunction. Though genetically, clinically and pathologically distinct, a commo...
The role of perivascular adipose tissue, white adipose tissue, and brown adipose tissue in the pathophysiological effects of ethanol [0.03%]
乙醇病理生理效应中的血管周围脂肪组织、白色脂肪组织和棕色脂肪组织的作用
Thales M H Dourado,Carlos R Tirapelli
Thales M H Dourado
Adipose tissue plays a crucial role in energy storage, but it also acts as an endocrine organ by secreting hormones and pro-inflammatory molecules. It regulates various processes, including adipogenesis, metabolism, and inflammation. White ...
Yomna Badawi,Christi L Kolarcik
Yomna Badawi