HSP90α-USP7-DNMT1 Axis Drives Hepatocellular Carcinoma Recurrence After Microwave Ablation by Disrupting ACSS3-Mediated Propionate Metabolism [0.03%]
热消融后肝癌复发的新机制:HSP90α-USP7-DNMT1信号轴通过破坏ACSS3介导的丙酸代谢驱动肿瘤免疫逃逸
Ye Chen,Jiaxin Bei,Xinkun Huang et al.
Ye Chen et al.
Insufficient microwave ablation (iMWA) of hepatocellular carcinoma (HCC) often leads to rapid and aggressive recurrence, and effective intervention remains a formidable challenge. Here, we show that the DNA methylation machinery is aberrant...
Cell-penetrating asymmetric siRNA targeting MyD88 suppresses inflammasome-driven ocular degeneration and angiogenesis [0.03%]
靶向MyD88的细胞穿膜型不对称siRNA可抑制炎症小体驱动的眼部退行性病变和血管生成
Juhong Kim,Saehong Min,Munjeong Yum et al.
Juhong Kim et al.
Chronic inflammation mediated by innate immune signaling contributes to retinal degeneration, pathological angiogenesis, and ocular surface damage in age-related macular degeneration (AMD) and dry eye disease (DED). Myeloid differentiation ...
Targeting vaccine fusion proteins to APCs increases immunogenicity of adenoviral and mRNA-LNP vaccines [0.03%]
靶向APC的疫苗融合蛋白可增强腺病毒和mRNA-LNP疫苗的免疫原性
Marlene Fyrstenberg Laursen,Francis Combes,Arnar Gudjonsson et al.
Marlene Fyrstenberg Laursen et al.
mRNA-lipid nanoparticle (LNP) and adenoviral delivery of vaccines have proven effective during the COVID-19 pandemic. Herein, we explored whether antigen-presenting cell (APC)-targeting of antigens could further enhance immunogenicity of th...
Discovery of circadian clock activators with anti-obesity efficacy via suppression of adipocyte development and hypertrophy [0.03%]
通过抑制脂肪细胞发育和肥大发现节律钟激活剂并用于抗肥胖疗效研究
Xuekai Xiong,Jemima Pangemanan,Tali Kiperman et al.
Xuekai Xiong et al.
Circadian clock-driven orchestration of metabolic pathways in adipocytes is required to maintain nutrient homeostasis, and clock disruption predisposes to the development of obesity and insulin resistance. However, pharmacological means to ...
A compact GAD67 promoter enables inhibitory neuron-targeted AAV gene therapy for seizure suppression [0.03%]
一个紧凑的GAD67启动子能够使AAV基因疗法针对抑制性神经元以抑制癫痫发作
Yuuki Fukai,Ayumu Konno,Nobutake Hosoi et al.
Yuuki Fukai et al.
Epilepsy arises from disruption of excitation-inhibition (E/I) balance, typically due to excessive excitatory activity. Despite available therapies, a substantial proportion of patients remain treatment resistant. Enhancing inhibitory neuro...
Francesca Ferraresso,Chad W Skaer,Christian J Kastrup
Francesca Ferraresso
Rethinking lipid nanoparticle design: Single-particle insights into RNA payload distribution and gene-editing efficiency [0.03%]
重新思考脂质纳米颗粒的设计：单粒子视角下的RNA负载分布和基因编辑效率的见解
Sushant Kulkarni
Sushant Kulkarni
Focused CRISPR screening to design fit-for-purpose CAR T cell therapies [0.03%]
针对不同目的的CAR-T细胞治疗的CRISPR筛选方法设计
Nina La Vonne Denne,Krishanu Saha
Nina La Vonne Denne
Mark J G Bakkers,Johannes P M Langedijk
Mark J G Bakkers