DC vaccine loaded with Bacteroides fragilis elicits functional cross-reactivity and enhances anti-PD-1 immunotherapy [0.03%]
脆弱拟杆菌载荷的瘤内注射细菌DNA疫苗诱导功能交叉反应并增强抗PD-1免疫治疗
Shichuan Hu,Gang Shi,Jing Zhao et al.
Shichuan Hu et al.
The gut microbiome profoundly influences the clinical benefits of antitumor immunotherapy. Although various gut microbiota have been shown to enhance immunotherapy, their clinical application remains unexplored. In this study, a dendritic c...
DC vaccine loaded with Bacteroides fragilis elicits functional cross-reactivity and enhances anti-PD-1 immunotherapy [0.03%]
脆弱拟杆菌载荷的肿瘤疫苗诱导功能交叉反应并增强抗PD-1免疫疗法
Shichuan Hu,Gang Shi,Jing Zhao et al.
Shichuan Hu et al.
The gut microbiome profoundly influences the clinical benefits of antitumor immunotherapy. Although various gut microbiota have been shown to enhance immunotherapy, their clinical application remains unexplored. In this study, a dendritic c...
Viral gene replication enhances AAV vector quality and reduces manufacturing costs [0.03%]
病毒基因复制可提高AAV载体质量并降低制造成本
Hao Liu,Ailing Du,Nan Liu et al.
Hao Liu et al.
Viral vectors for gene and cell therapy are typically produced by transfecting plasmids into mammalian cells. Because plasmid DNA is not replicated in these cells, large quantities are required to express sufficient viral proteins for vecto...
Viral gene replication enhances AAV vector quality and reduces manufacturing costs [0.03%]
病毒基因复制可提高AAV载体质量并降低制造成本
Hao Liu,Ailing Du,Nan Liu et al.
Hao Liu et al.
Viral vectors for gene and cell therapy are typically produced by transfecting plasmids into mammalian cells. Because plasmid DNA is not replicated in these cells, large quantities are required to express sufficient viral proteins for vecto...
Engineering T cells in vivo to express a synthetic cytokine receptor enables preferential expansion and enrichment of anti-CD22 CAR T cells [0.03%]
体内工程改造T细胞表达合成细胞因子受体，以实现抗CD22嵌合抗原受体T细胞的优先扩增和富集
Travis J Friesen,Alyssa Sheih,Nikole Perdue et al.
Travis J Friesen et al.
Ex vivo-manufactured chimeric antigen receptor (CAR) T cells targeting CD19 have transformed treatment strategies for patients with B cell malignancies and shown promising results in autoimmune disease. Yet despite their success, significan...
Targeting the MNK1-MYH9 Axis Blocks YAP1 Recruitment to Prevent Thrombosis and Platelet Activation-Induced NETosis [0.03%]
靶向MNK1-MYH9轴可防止血栓形成和活化血小板诱导的NETosis
Kang Liu,Xinke Fang,Jingjun Sheng et al.
Kang Liu et al.
Platelet activation and neutrophil extracellular trap (NET) formation are critical drivers of immunothrombosis, yet the molecular crosstalk governing these processes remains incompletely understood. In this study, we unveil a distinct regul...
A modified cyclosporine enhances lentivector transduction ex vivo and in vivo by degrading IFITM3 [0.03%]
环孢素衍生物通过降解IFITM3增强慢病毒载体的体内外转导能力
Dara Annett,Bethan J Critchley,Kate L Morling et al.
Dara Annett et al.
Intrinsic innate immune barriers have evolved to suppress viral infection and can reduce effective gene delivery in gene therapy. We have developed BG147, a novel cyclosporine A (CsA) analogue optimised via structure-guided design to specif...
Laszlo Radvanyi
Laszlo Radvanyi
ASGCT 2026 oral session meeting summary: AAV cell line development and engineering [0.03%]
ASGCT 2026口头会议总结：AAV细胞系开发和工程
Frank Agbogbo,Michelle Hussong,Efrain Guzman et al.
Frank Agbogbo et al.
Accelerated design of antiviral peptides to clamp down on emerging pathogens [0.03%]
针对新发病原的抗病毒肽设计优化
Katherine A Fitzgerald,Terence R Flotte
Katherine A Fitzgerald