Decoding resistance in triple-negative breast cancer: NF-κB as a therapeutic target for oncolytic virotherapy [0.03%]
解码三阴性乳腺癌的抗药性：NF-κB作为溶瘤病毒疗法的治疗靶点
Afsar U Ahmed
Afsar U Ahmed
The power of one: The unexpected benefits of correcting a single tissue in multisystem mitochondrial disease [0.03%]
一石激起千层浪——单一组织的修复带来渐渗性线粒体疾病的多重效益
Carlos T Moraes
Carlos T Moraes
Repurposing Triamterene as Chloride Intracellular Channel 1 Inhibitor via Ligand-Based Approach: A Novel Adjuvant Treatment for Glioblastoma [0.03%]
基于配体的再定位发现三胺替林通过抑制氯离子细胞内通道1成为胶质母细胞瘤的潜在增效治疗药物
Federica Barbieri,Francesca Cianci,Beatrice Federica Tremonti et al.
Federica Barbieri et al.
Identification of effective therapies for glioblastoma is an unmet need in clinical oncology. The antidiabetic drug metformin has been recommended as a repurposed treatment for glioblastoma, mainly acting as a blocker of chloride intracellu...
From silence to signal: Redirecting apoptotic cell clearance to fuel antitumor T cell immunity [0.03%]
从沉默到信号：重定向抗肿瘤T细胞免疫的凋亡细胞清除方向
Manikandan Subramanian
Manikandan Subramanian
From molecular correction to circuit repair: Expanding the therapeutic horizon of gene augmentation [0.03%]
从分子矫正到回路修复：基因补充治疗的前景展望
Hongli Zhang,Hongyan Shu,Yuting Li et al.
Hongli Zhang et al.
Engineering the gut as an auxiliary tyrosine disposal unit in hereditary tyrosinemia type 1 [0.03%]
工程改造肠道作为遗传性高苯丙氨酸血症1型的辅助酪氨酸处置单位
Joery De Kock,Massimiliano Paganelli,Jessie Neuckermans
Joery De Kock
Injectable bioinstructive microfoam for rapid bedside/in vivo programming of CAR-T cells [0.03%]
一种可注射生物指令微泡沫，可在病床旁/体内快速编程CAR-T细胞
Sirkka B Stephan,Carrie L Cummings,Katelyn Fitzgerald et al.
Sirkka B Stephan et al.
While chimeric antigen receptor (CAR) T-cell therapies have transformed the treatment of hematological malignancies and are being explored for solid tumors, their widespread use remains limited by high costs, complex manufacturing requireme...
Precise hepatic base editing of ASGR1 enables robust and durable LDLR-independent lipid lowering in vivo [0.03%]
精确的ASGR1肝脏基础编辑使体内LDLR独立的脂质降低更为有效和持久
Yaofeng Hou,Yaxin Luo,Jiabei Chen et al.
Yaofeng Hou et al.
Familial hypercholesterolemia (FH), most frequently caused by LDLR loss-of-function variants, is a common autosomal dominant disorder that leads to early-onset, life-threatening cardiovascular disease. Therapeutic options for LDLR-deficient...
A Singular Base Editing Platform for Polyfunctional Multiplex Engineering of Immune Cells [0.03%]
一种用于免疫细胞多功能多重工程改造的特殊碱基编辑平台
Joseph G Skeate,Nicholas J Slipek,Walker S Lahr et al.
Joseph G Skeate et al.
Current methods to engineer antigen-specific receptors rely on randomly integrating vectors or double-strand break induced targeted integration, both of which pose safety risks. To implement an all-in-one tool for multiplex knockout (KO) an...
Hybrid AAV-LNP transposition system lowers the therapeutic threshold and improves transgene stability for liver-directed gene therapy [0.03%]
杂交AAV-LNP转座系统降低治疗阈值并改善肝脏导向基因治疗的转基因稳定性
Randy J Chandler
Randy J Chandler