Engineered tRNA: Beyond one gene, restoring function, not just full-length protein [0.03%]
工程化tRNA：不止于一个基因，恢复功能而不仅仅是合成全长蛋白质
Pawan K Shahi,Bikash R Pattnaik
Pawan K Shahi
Zhongkun Zhang,Siyu Yao,Ethan Loo et al.
Zhongkun Zhang et al.
Repurposing base editors for targeted knock-in and simultaneous multiplex knockouts to generate allo-CAR T cells with minimal translocations [0.03%]
体内高效制备低转座的通用型CAR-T细胞
Glaser Viktor,Becker Lily Jo,Fuster-García Carla et al.
Glaser Viktor et al.
Multiplex genome editing of cellular therapies frequently requires multiple DNA double-strand breaks (DSBs), which can induce genotoxicity through chromosomal rearrangements and large deletions. Base editors enable targeted sequence changes...
CAR T cells secreting anti-EpCAM bi-specific T cell engagers overcome tumor heterogeneity in targeting various epithelial originated carcinomas [0.03%]
分泌抗EpCAM双特异性T细胞衔接器的CAR-T细胞克服了针对各种上皮来源癌肿瘤异质性的障碍
Bei Wang,Wen-Hsin Lee,Yuanyu Hu et al.
Bei Wang et al.
CAR T cell therapy to treat solid tumors has seen limited success, partly due to tumor heterogeneity and antigen escape. These barriers remain major challenges, as heterogeneous tumors often consist of diverse populations of cancer cells, w...
Efficient and Safe Transduction of Cochlear Outer Hair Cells in Adult Mice with AAV2.7m8-Myo15 [0.03%]
携带MYO15的AAV2.7m8转导小鼠耳蜗外毛细胞的有效性和安全性
Weilong Wang,Xi Dai,Danqi Wang et al.
Weilong Wang et al.
Adeno-associated virus vector-mediated inner ear gene therapy has gradually achieved successful clinical translation in individual treatment regimens. However, the low transduction efficiency of AAV vectors in the outer hair cells of adult ...
Mitochondrial capsules: A revolutionary organelle therapy for mitochondrial and neurodegenerative diseases [0.03%]
线粒体囊泡：一种革命性的细胞器疗法，用于治疗线粒体和神经退行性疾病
Yaguang Zhang,Xuyang Yang,Mingtian Wei
Yaguang Zhang