Targeting the MNK1-MYH9 Axis Blocks YAP1 Recruitment to Prevent Thrombosis and Platelet Activation-Induced NETosis [0.03%]
靶向MNK1-MYH9轴可防止血栓形成和活化血小板诱导的NETosis
Kang Liu,Xinke Fang,Jingjun Sheng et al.
Kang Liu et al.
Platelet activation and neutrophil extracellular trap (NET) formation are critical drivers of immunothrombosis, yet the molecular crosstalk governing these processes remains incompletely understood. In this study, we unveil a distinct regul...
A modified cyclosporine enhances lentivector transduction ex vivo and in vivo by degrading IFITM3 [0.03%]
环孢素衍生物通过降解IFITM3增强慢病毒载体的体内外转导能力
Dara Annett,Bethan J Critchley,Kate L Morling et al.
Dara Annett et al.
Intrinsic innate immune barriers have evolved to suppress viral infection and can reduce effective gene delivery in gene therapy. We have developed BG147, a novel cyclosporine A (CsA) analogue optimised via structure-guided design to specif...
Laszlo Radvanyi
Laszlo Radvanyi
ASGCT 2026 oral session meeting summary: AAV cell line development and engineering [0.03%]
ASGCT 2026口头会议总结：AAV细胞系开发和工程
Frank Agbogbo,Michelle Hussong,Efrain Guzman et al.
Frank Agbogbo et al.
Accelerated design of antiviral peptides to clamp down on emerging pathogens [0.03%]
针对新发病原的抗病毒肽设计优化
Katherine A Fitzgerald,Terence R Flotte
Katherine A Fitzgerald
A combinatorial EVs-miRNA signature mediates the anti-tumoral activity of NFAT3-regulated extracellular vesicles in aggressive cancers [0.03%]
NFAT3调节的外泌体介导了EVs-miRNA信号通路的抗肿瘤作用
Guénolé Tossou,Nadia Ourari,Maëlle Ralu et al.
Guénolé Tossou et al.
Aggressive cancers such as triple-negative breast cancer (TNBC) and pancreatic cancer remain difficult to treat because their malignant behavior is driven by complex gene networks rather than single oncogenic targets. Here, we identify an e...
Triple AAV Intein-Mediated Gene Therapy Ameliorates Dystrophic Phenotype in MDC1A Mice [0.03%]
三载体intein介导的基因治疗改善MDC1A小鼠的营养不良表型
Núria Rafel-Millan,Carles Bayod-Girón,Maria Pallarès-Masmitjà et al.
Núria Rafel-Millan et al.
Several therapies using adeno-associated virus (AAVs) as gene delivery tool have received marketing approval in the past. However, potential applications of AAVs are limited by their restricted gene packaging capacities (
Lineage-Tailored Vesicles from Human Retinal Ganglion-Like Cells Drive Metabolic Homeostasis and Bioenergetic Recovery in Glaucoma [0.03%]
人视网膜神经节细胞样细胞系来源的囊泡通过调节代谢稳态和生物能量学恢复治疗青光目
Sandeep Kumar Vishwakarma,Mallikarjuna Rao Gedda,Stanislav I Tomarev
Sandeep Kumar Vishwakarma
Retinal ganglion cells (RGCs) exhibit high bioenergetic demands, rendering them vulnerable to mitochondrial dysfunction and metabolic collapse during glaucomatous neurodegeneration. Therapeutic strategies capable of restoring mitochondrial ...
Dysregulated Proline Metabolism Contributes to Retinal Fibrosis in Neovascular AMD: Therapeutic Potential of Prolyl-4-Hydroxylase Inhibition [0.03%]
脯氨酸代谢紊乱促进新生血管性年龄相关性黄斑变性的视网膜纤维化：脯氨酰羟化酶抑制的治疗潜力
Yue Zeng,Ting Zhang,Elisa Cornish et al.
Yue Zeng et al.
Subretinal fibrosis, a major cause of irreversible vision loss in neovascular age-related macular degeneration (nAMD), is driven by excessive deposition of extracellular matrix such as collagens. While proline metabolism is known to play a ...
Capless self-amplifying mRNA vaccine induces dose-sparing protective immunity against HPAI clade 2.3.4.4 H5 virus in mice [0.03%]
无封端的自我放大型mRNA疫苗可在小鼠中诱导对抗高致病性禽流感H5病毒 clade 2.3.4.4的省剂量保护性免疫反应
Beom Kyu Kim,Ji-Hyun Park,Won-Suk Choi et al.
Beom Kyu Kim et al.
Self-amplifying mRNA (samRNA) vaccines can induce potent immune responses at lower doses than conventional non-replicating mRNA vaccines; however, large RNA size and manufacturing considerations associated with 5' capping remain important c...