Enhanced mucosal SARS-CoV-2 immunity after heterologous intramuscular mRNA prime/intranasal protein boost vaccination with a combination adjuvant [0.03%]
基于联合佐剂的异源肌肉注射mRNA疫苗序贯鼻内蛋白质加强针诱导黏膜免疫增强反应对抗SARS-CoV-2挑战攻击
Gabriel Laghlali,Matthew J Wiest,Dilara Karadag et al.
Gabriel Laghlali et al.
Current COVID-19 mRNA vaccines delivered intramuscularly (IM) induce effective systemic immunity, but with suboptimal immunity at mucosal sites, limiting their ability to impart sterilizing immunity. There is strong interest in rerouting im...
Ex vivo-generated human CD1c+ regulatory B cells by a chemically defined system suppress immune responses and alleviate graft-versus-host disease [0.03%]
体外化学成分明确体系诱导的人CD1C+调节性B细胞抑制免疫反应并缓解移植物抗宿主病
Yingying Bao,Jialing Liu,Zhishan Li et al.
Yingying Bao et al.
IL-10+ regulatory B cells (Bregs) show great promise in treating graft-versus-host disease (GVHD), a life-threatening complication of post-hematopoietic stem cell transplantation. However, obtaining high-quality human IL-10+ Bregs in vitro ...
Reversion of metabolic dysfunction-associated steatohepatitis by skeletal muscle-directed FGF21 gene therapy [0.03%]
骨骼肌定向FGF21基因治疗逆转代谢紊乱相关肝炎
Veronica Jimenez,Victor Sacristan,Claudia Jambrina et al.
Veronica Jimenez et al.
The highly prevalent metabolic dysfunction-associated steatohepatitis (MASH) is associated with liver steatosis, inflammation, and hepatocyte injury, which can lead to fibrosis and may progress to hepatocellular carcinoma and death. New tre...
Recombinant adeno-associated virus as a delivery platform for ocular gene therapy: A comprehensive review [0.03%]
重组腺相关病毒作为眼科基因治疗递送平台的研究进展：全面综述
Jiang-Hui Wang,Wei Zhan,Thomas L Gallagher et al.
Jiang-Hui Wang et al.
Adeno-associated virus (AAV) has emerged as a leading platform for in vivo gene therapy, particularly in ocular diseases. AAV-based therapies are characterized by low pathogenicity and broad tissue tropism and have demonstrated clinical suc...
Combined intraocular and intravenous gene delivery for therapy of gyrate atrophy of the choroid and retina [0.03%]
玻璃体腔内联合静脉给药治疗脉络膜及视网膜进行性变性
Fabio Dell&#x;Aquila,Roberto Di Cunto,Elena Marrocco et al.
Fabio Dell&#x;Aquila et al.
Gyrate atrophy of the choroid and retina (GACR) is due to ornithine aminotransferase (OAT) deficiency, which causes hyperornithinemia, leading to retinal pigment epithelium, followed by choroidal and retinal degeneration. Adeno-associated v...
Liver-directed AAV gene therapy normalizes disease symptoms and provides cross-correction in a model of lysosomal acid lipase deficiency [0.03%]
肝定向的AAV基因治疗可改善溶酶体酸性脂肪酶缺乏模型小鼠的症状，并产生跨组织效应
Patricia Lam,Deborah A Zygmunt,Anna Ashbrook et al.
Patricia Lam et al.
Lysosomal acid lipase deficiency (LAL-D) is caused by mutations in the LIPA gene, which encodes the lysosomal enzyme that hydrolyzes triglycerides and cholesteryl esters to free fatty acids and free cholesterol. The objective of this study ...
Targeting intratumoral Tregs: The promise of CD25×TIGIT bispecific antibodies in solid tumor therapy [0.03%]
靶向瘤内调节性T细胞：CD25×TIGIT双特异性抗体在实体肿瘤治疗中的前景
Muthukumaran Venkatachalapathy
Muthukumaran Venkatachalapathy
Transcriptional orchestration of EMT: Unraveling novel molecular targets in pulmonary fibrosis [0.03%]
转录调控EMT：揭示肺纤维化中新的分子靶点
Sylwia Bobis-Wozowicz,Milena Paw
Sylwia Bobis-Wozowicz
Does increased CCL2-mediated immune cell recruitment during mucosal BCG vaccination provide superior protection against TB? [0.03%]
增加的CCL2介导的黏膜BCG免疫细胞募集能否有效增强对结核病的保护作用？
Gregory Serpa,Emily A Hemann,Matthew E Long
Gregory Serpa