Claudio Bordignon [0.03%]
克劳迪奥·博尔迪尼翁
Alessandro Aiuti,Chiara Bonini,Fabio Ciceri et al.
Alessandro Aiuti et al.
Increasing Intrinsic Protein Disorder Improves CD8+ Immunogenicity for a SARS CoV2 Vaccine Candidate Antigen [0.03%]
提高内在无序性可增强SARS-CoV-2疫苗候选抗原的免疫原性
Li Wan,Bingxian Xie,Masahiro Shuda et al.
Li Wan et al.
CD8+ T cell targeting of the conserved SARS CoV2 RNA-dependent RNA polymerase (RdRp, nsp12) may offer a means for cross-protection against diverse coronavirus strains. Native RdRp, however, displays primary sequence immunoevasion (PSI) that...
Evaluating the effects of aging on biodistribution and gene silencing activity of lipid-siRNA conjugates delivered into cerebrospinal fluid [0.03%]
评估脂质体siRNA连接物递送入脑脊液后的老化对其生物分布和基因沉默活性的影响
Alexander P Ligocki,Alexander G Sorets,Adam M Abdulrahman et al.
Alexander P Ligocki et al.
Aging is the primary risk factor for chronic neurodegenerative diseases and is associated with alterations to cerebrospinal fluid (CSF) flow and clearance. CSF delivery is currently the most clinically advanced route of administration for o...
The self-replicating RNA platform expands to cancer immunotherapy with next-generation Eastern equine encephalitis virus vectors [0.03%]
自我复制型RNA平台通过下一代东方马脑炎病毒载体拓展到癌症免疫治疗领域
Lundstrom Kenneth
Lundstrom Kenneth
The thymidine analog azidothymidine potentiates the immunomodulatory function of interferon-α in adult T-cell leukemia/lymphoma [0.03%]
胸腺嘧啶类似物叠氮胸苷增强干扰素-α在T细胞白血病/淋巴瘤中的免疫调节功能
Xiaoyi Yuan,Dian Zhu,Yi Liang et al.
Xiaoyi Yuan et al.
Adult T-cell leukemia/lymphoma (ATLL), caused by human T-cell leukemia virus type 1 (HTLV-1), is an aggressive malignancy with limited treatment options. Although the combination therapy of azidothymidine (AZT) and interferon-α (IFN-α) ha...
Cerebrospinal Delivery of a Bidirectional Aav9 Vector Improves Optic Nerve and Retinal Pathology in a Sheep Model of Tay-Sachs Disease [0.03%]
双向AAV9载体的脑脊液递送可改善Tay-Sachs病羊模型的视神经和视网膜病理变化
Brett D Story,Sara M Thomasy,Sara A Adelman et al.
Brett D Story et al.
Tay-Sachs disease (TSD) is a fatal neurodegenerative lysosomal storage disease. The Jacob sheep is the only large animal model of TSD, yet ocular pathology and the therapeutic potential of gene therapy remain poorly defined. Sheep cohorts i...
Antibody Format Matters: A Comparative Analysis of VHH and scFv Domains Reveals Superior In Vivo CAR T Cell Function with VHH Domains [0.03%]
抗体类型很重要：VHH和scFv结构域的比较分析显示VHH域具有更好的体内CAR-T细胞功能
Alexander Kinna,Preeta Datta,Reyisa Bughda et al.
Alexander Kinna et al.
Chimeric antigen receptor (CAR) T cells require an extracellular targeting domain for antigen specificity, typically a scFv. VHH antibodies are emerging as alternative CAR binding regions due to their reduced size, improved stability and CD...
Targeting emerging respiratory pathogens with Clamp Peptides: broad-spectrum inhibition of viral entry in 3D human lung models [0.03%]
靶向新兴呼吸道病原体的Clamp多肽：在三维人类肺模型中广泛抑制病毒入侵
Mercedes Lozano-Garcia,Josep-Ramon Codina,Marcello Mascini et al.
Mercedes Lozano-Garcia et al.
Rapid urbanization, migration and climate change are accelerating the appearance and diversification of respiratory viruses, overwhelming the pace at which conventional drugs can be discovered and manufactured. Here we report a fast-respons...
Therapeutic potential of three-dimensional hepatocyte-like cells from human adipose-derived mesenchymal stem cells in urea cycle disorders [0.03%]
人脂肪来源间充质干细胞肝细胞样三维培养用于尿素循环障碍的治疗潜力研究
Yu Saito,Shuhai Chen,Yuhei Waki et al.
Yu Saito et al.
Three-dimensional hepatocyte-like cells (3D HLCs) derived from human adipose-derived mesenchymal stem cells (ADSCs) represent a scalable and clinically accessible cell source for metabolic liver diseases. Here, the authors demonstrate that ...