Angela J Glading
Angela J Glading
Cardio-Hematopoietic Axis in Cardiac Injury and Repair: From Adaptation to Maladaptation [0.03%]
心脏损伤与修复过程中心血管-造血轴：从适应到失适
Douglas L Mann,Andrew I Schafer
Douglas L Mann
The cardiovascular and hematopoietic systems are functionally interconnected through the cardio-hematopoietic axis, a dynamic signaling network that governs hematopoietic responses following cardiac injury. Traditionally viewed primarily as...
Generation of hiPSC-Derived Brain Microvascular Endothelial Cells Using Directed Differentiation and Transcriptional Reprogramming [0.03%]
利用定向分化和转录重编程生成hiPSC来源的脑微血管内皮细胞
Aomeng Cui,Ronak Patel,Patrick Bosco et al.
Aomeng Cui et al.
Background: Modeling the human blood-brain barrier (BBB) is limited by the lack of robust protocols to generate induced pluripotent stem cell (iPSC)-derived brain microvascular endothelial cells (BMECs). Current methods g...
Can Nuclear Imaging Detect Trained Immunity in Cardiovascular Disease? [0.03%]
核医学 imaging 能检测心血管疾病中的 trained immunity 吗？
Abraham J P Teunissen,Mandy M T van Leent
Abraham J P Teunissen
Inflammation is a major driver of atherosclerotic cardiovascular disease, and the key roles of trained immunity in initiating and driving this condition are increasingly recognized. However, monitoring trained immunity in patients, particul...
Endothelial CEPT1 Promotes Angiogenesis Through PPARα and VEGF-A Signaling [0.03%]
内皮细胞CEPT1通过PPARα和VEGF-A信号促进血管生成
Tariq J Khan,Rodrigo Meade,Santiago Elizondo-Benedetto et al.
Tariq J Khan et al.
Background: Cept1 is essential for de novo phopholipogenesis and is impacted by diabetes. We previously demonstrated that conditional knockdown of Cept1 in the endothelium leads to reduced tissue recovery. Therefore, we h...
Role of the Plasminogen Activation System in Liver Injury and Repair: Knowns and Known Unknowns [0.03%]
纤溶系统在肝损伤与修复中的作用：已知和未知的内容
Dayita Banerjee,Zimu Wei,James P Luyendyk
Dayita Banerjee
The plasminogen activation system (PAS) is primarily responsible for the degradation of fibrin clots as well as extracellular matrix remodeling. Many components of the PAS are produced by the liver, and the expression of these proteins is a...
Guofang Wang,Yu Yan,Qian Sun et al.
Guofang Wang et al.
Atherosclerosis, a leading cause of cardiovascular diseases, is a chronic, progressive condition driven by lipid dysregulation, endothelial dysfunction, and immune cell infiltration. The PPAR (peroxisome proliferator-activated receptor) fam...
Lipoprotein(a) and the Vascular Redox Interface: Linking Arteriosclerosis, Thrombosis, and Vascular Biology [0.03%]
脂蛋白(a)与血管氧化还原界面：动脉粥样硬化、血栓和血管生物学之间的联系
Rafael Zubiran,Alan T Remaley
Rafael Zubiran
Frederik Denorme
Frederik Denorme
Jessie Shea,Calvin De Louche,Tabitha Grainger et al.
Jessie Shea et al.
Sex and reproductive history are established nontraditional risk factors for cardiovascular disease, but their relevance for peripheral artery disease (PAD) remains unclear. This narrative review examines the current evidence surrounding un...