Yaqun Fang,Zhiye Zhang,Qiqi Cao et al.
Yaqun Fang et al.
Background: ApoB (apolipoprotein B)-containing lipoproteins are causal risk factors for atherosclerotic coronary artery disease (CAD). Since human cathelicidin LL-37 binds to ApoB-100 in this pathological context, we inve...
Sarah-Anne E Nicholas,Stephen B Helming,Antoine Ménoret et al.
Sarah-Anne E Nicholas et al.
Background: Atherosclerotic plaques form through lipid and immune cell accumulation beneath the arterial endothelium. CD8 T cells are abundant in lesions, and their activation correlates with cardiovascular disease severi...
Coen van Solingen,Matthew Muller,Marcin A Sowa et al.
Coen van Solingen et al.
Meenakshi Rana,Una Rose Wilcox,Suchita Nadkarni
Meenakshi Rana
The placenta is a highly specialized organ that ensures the developing fetus gets adequate oxygen and nutrients from its mother. The placenta shares common development pathways with the fetal heart and releases factors that can influence th...
Mary G Sorci-Thomas,Alexander Rocksvold,Bilal Ahmad
Mary G Sorci-Thomas
PCPE (procollagen C-endopeptidase enhancer) 1 and PCPE2 are ECM (extracellular matrix) glycoproteins that lack intrinsic protease activity and regulate procollagen processing. Initially, these glycoproteins were found to be structurally rel...
Selina M Tucker,Nataliia Hula,Jennifer J Gardner et al.
Selina M Tucker et al.
Preeclampsia is a pregnancy disorder characterized by de novo maternal hypertension, end-organ damage, and fetal complications. It is also associated with increased long-term cardiovascular risk for both the mother and offspring. A general ...
Integrated Forward and Reverse Degradomics of Aortic Aneurysms Uncovers Their Proteolytic Landscapes and the Roles of MMP9 and Mast Cell Chymase [0.03%]
Sumit Bhutada,Daniel R Martin,Frank Cikach et al.
Sumit Bhutada et al.
Background: Dysregulated proteolysis is implicated in thoracic (thoracic aortic aneurysm [TAA]) and abdominal aortic aneurysm (AAA) pathogenesis, but proteolytic landscapes (degradomes) of aneurysmal and normal aorta and ...
Activin A-Endothelin-1 Axis Governs Pulmonary Vascular Remodeling: Mechanistic Basis for Emerging Therapies in PAH [0.03%]
Novia Nurul Faizah,Gusty Rizky Teguh Ryanto,Sagita Mega Sekar Kencana et al.
Novia Nurul Faizah et al.
Background: Pulmonary arterial hypertension remains a life-threatening disease despite advances in vasodilator therapy. Vascular remodeling, partly driven by pulmonary artery endothelial cell dysfunction, is accompanied b...
Impairment of Macrophage Functions by the Senescence-Associated Secretory Phenotype of Vascular Smooth Muscle Cells-Brief Report [0.03%]
Dimitrios Tsitsipatis,Tatiana Rodriguez Rivera,Mary Kaileh et al.
Dimitrios Tsitsipatis et al.
Background: This study aimed to determine the effect of senescent vascular smooth muscle cells (VSMCs) on foam cell formation and macrophage phagocytic activity in atherosclerotic conditions. ...
ILK (Integrin-Linked Kinase)-Dependent Modulation of DPP4 (Dipeptidyl Peptidase 4) Prevents Progression of Calcific Aortic Valve Disease [0.03%]
Maria Delgado-Marin,Sandra Sánchez-Esteban,Alberto Cook-Calvete et al.
Maria Delgado-Marin et al.
Background: Calcific aortic valve disease (CAVD) is characterized by endothelial dysfunction, fibrosis, and osteogenic calcification, yet the molecular mechanisms driving disease progression remain incompletely understood...