Generation of ciBMECs: Endothelial Cells Acquire Blood-Brain Barrier Identity and Function Through Wnt Activation [0.03%]
通过Wnt激活生成ciBMECs：内皮细胞获得血脑屏障身份和功能
Hao Yang,Yao Zhang,Peizhe Wang et al.
Hao Yang et al.
LDLR-3'UTR Deletions Identified as a Genetic Cause of Hypobetalipoproteinemia: Evidence From Familial and Population-Based Studies [0.03%]
家系和人群研究鉴定LDLR 3' UTR缺失为低β脂蛋白血症的致病原因
Antoine Lainé,Zoé Begué-Racapé,Pierre Lindenbaum et al.
Antoine Lainé et al.
FUT8-Dependent Core Fucosylation: Essential for Platelet Function and a Target in Thrombosis [0.03%]
FUT8依赖的核心岩藻糖基化：血小板功能的必要条件和抗血栓靶点
Ruey-Bing Yang,Cheng-Fen Tu,Yan-Ting Chen et al.
Ruey-Bing Yang et al.
Background: FUT8 (fucosyltransferase 8) adds core fucose to the innermost N-acetylglucosamine of N-glycans on surface receptors, affecting ligand binding and downstream signaling in various cellular contexts. Here, we exa...
Endothelial Susceptibility-Related Genetic Variants and Hypertensive Disorders of Pregnancy [0.03%]
与内皮细胞易感性相关的遗传变异和妊娠期高血压疾病
Linke Li,Yu Zhang,Buu Truong et al.
Linke Li et al.
Background: The hypertensive disorders of pregnancy (HDPs), that is, preeclampsia and gestational hypertension, are characterized by endothelial dysfunction in pregnancy and are epidemiologically and genetically associate...
Cardiovascular Risk Reduction: What Can Brown (Adipose Tissue) Do for You? [0.03%]
棕色（脂肪组织）能帮你降低心血管风险吗？
Khanh-Van Tran,Timothy P Fitzgibbons
Khanh-Van Tran
Arterial Shear Spectra Influence Endothelial Function and Are Regulated by Vascular Resistance [0.03%]
动脉剪切谱影响内皮功能并受血管阻力调节
Joshua M Cherubini,Calvin M Armstrong,Michael J Kamal et al.
Joshua M Cherubini et al.
Background: Biophysical interactions between forces exerted by blood and the vascular endothelium influence atherogenesis. The accurate characterization of these relationships, however, is obfuscated by the variety of met...
No Effect of Ppm1d-Mutant Clonal Hematopoiesis on Atherosclerosis Development in Mice [0.03%]
小鼠Ppm1d基因突变型克隆型造血对动脉粥样硬化发病无影响
Marta Amorós-Pérez,María A Zuriaga,Virginia Zorita et al.
Marta Amorós-Pérez et al.
Background: Clonal hematopoiesis driven by somatic mutations is an emerging cardiovascular risk factor, and the DNA damage response gene PPM1D is among the most frequently mutated genes. Mutations in PPM1D are enriched in...
Angiotensin II Induces Abdominal Aortic Branch Aneurysms in Fibrillin-1C1041G/+ Mice [0.03%]
血管紧张素Ⅱ诱导Fibrillin-1C1041G/+小鼠腹主动脉瘤形成
Michael K Franklin,Deborah A Howatt,Jessica J Moorleghen et al.
Michael K Franklin et al.
Background: Mice harboring a missense variant (C1041G) of Fbn1 have been used extensively for aortopathy research, but do not mimic all facets of the human disease. The role of increased AngII (angiotensin II) or blood pr...
Fusobacterium nucleatum- Derived Isoleucine Exacerbates Aneurysm by Inducing Ferroptosis in Vascular Smooth Muscle Cells [0.03%]
核梭杆菌衍生的异亮氨酸通过在血管平滑肌细胞中诱导铁死亡来加剧动脉瘤恶化
Liang Chen,Lu Lin,Zheyu Wang et al.
Liang Chen et al.
Background: Bacterial communities and their metabolites are increasingly recognized as key contributors to cardiovascular disease, yet their role and mechanistic involvement in abdominal aortic aneurysm (AAA) pathogenesis...
Therapeutic Strategies Combining Antiplatelet With Anticoagulant Actions: Heparin Proteoglycan Mimetic APAC as a Model [0.03%]
兼具抗血小板与抗凝作用的联合治疗策略——以肝素糖胺聚糖 mimetic apac为例
Axelle Y Kern,Annukka Jouppila,Hanna Pitkänen et al.
Axelle Y Kern et al.
Current antithrombotic therapies (combining aspirin, P2Y12 inhibitors, and anticoagulants) target both platelet and coagulation pathways to reduce ischemic events in high-risk cardiovascular patients. Despite efficacy, these regimens are li...