Roles of Hydrogen Sulfide in Hypertension Development and Its Complications: What, So What, Now What [0.03%]
氢硫化物在高血压发病及其并发症发生中的作用：是什么，意味着什么，今后应该怎样做？
Rui Wang
Rui Wang
Hypertension is a multicause health challenge, and hydrogen sulfide (H2S) is a multifunctional gasotransmitter. A critical pathologic role of endogenous H2S deficiency in the development of hypertension was established 15 years ago based on...
Early-Life Cardiovascular Risk Factor Trajectories and Vascular Aging in Midlife: A 30-Year Prospective Cohort Study [0.03%]
基于30年的前瞻性队列研究探讨生命早期心血管危险因素轨迹与中年血管衰老的关系
Yang Wang,Jie Wang,Xiao-Wei Zheng et al.
Yang Wang et al.
Background: Vascular aging, as assessed by structural and functional arterial properties, is an independent predictor of cardiovascular outcomes. We aimed to explore the associations of individual cardiovascular risk fact...
Circadian Misalignment Impacts the Association of Visceral Adiposity With Elevated Blood Pressure in Adolescents [0.03%]
昼夜节律失调影响青少年内脏脂肪与血压升高的关系
Natasha Morales-Ghinaglia,Michael Larsen,Fan He et al.
Natasha Morales-Ghinaglia et al.
Background: Although insufficient sleep has been shown to contribute to obesity-related elevated blood pressure, the circadian timing of sleep has emerged as a novel risk factor. We hypothesized that deviations in sleep m...
Specific HIF-2α (Hypoxia-Inducible Factor-2) Inhibitor PT2385 Mitigates Placental Dysfunction In Vitro and in a Rat Model of Preeclampsia (RUPP) [0.03%]
一种特定的HIF-2α抑制剂PT2385通过体外实验和减少胎盘功能障碍缓解子痫前期模型中的胎盘功能障碍
Arthur Colson,Christophe Louis Depoix,Isaline Lambert et al.
Arthur Colson et al.
Background: Preeclampsia is one of the leading causes of maternal mortality worldwide and is strongly associated with long-term morbidity in mothers and newborns. Referred to as one of the deep placentation disorders, ins...
Cullin 3 and Blood Pressure Regulation: Insights From Familial Hyperkalemic Hypertension [0.03%]
Cul3与血压调节：家族性高血钾性高血压研究的新进展
Yujiro Maeoka,Ryan J Cornelius,James A McCormick
Yujiro Maeoka
The study of rare monogenic forms of hypertension has led to the elucidation of important physiological pathways controlling blood pressure. Mutations in several genes cause familial hyperkalemic hypertension (also known as Gordon syndrome ...
Simin Gharib Lee,Naomi D L Fisher
Simin Gharib Lee
We stand at a critical juncture in the delivery of health care for hypertension. Blood pressure control rates have stagnated, and traditional health care is failing. Fortunately, hypertension is exceptionally well-suited to remote managemen...
Effect of Age on Hypertension Recognition in Children With Chronic Kidney Disease: A Report From the Chronic Kidney Disease in Children Study [0.03%]
年龄对慢性肾脏病儿童高血压认识的影响：来自儿童慢性肾脏病研究的报告
Chloe E Douglas,Jennifer Roem,Joseph T Flynn et al.
Chloe E Douglas et al.
Background: Young age has been associated with poorer control of hypertension in children with chronic kidney disease (CKD). Using data from the CKiD Study (Chronic Kidney Disease in Children), we examined the relationshi...
Phosphoproteomics Reveals the Wolframin-Calcium Axis as an Important Pathogenic Signaling Node in Primary Aldosteronism [0.03%]
磷酸化蛋白质组学揭示 wolframin-钙轴在原发性醛固酮增多症发病机制中的重要作用
Linqiang Ma,Shumin Yang,Yi Yang et al.
Linqiang Ma et al.
Background: Aldosterone-producing adenoma (APA) is a benign adrenal tumor with autonomous aldosterone production which causes hypertension and excess cardiovascular risk. Protein phosphorylation regulates aldosterone secr...
Khaled Elkholey,Amr Wahba,Sachin Y Paranjape et al.
Khaled Elkholey et al.
Edwin K Jackson,Delbert G Gillespie,Zaichuan Mi
Edwin K Jackson
Background: The endogenous purine 8-aminoguanine induces diuresis/natriuresis/glucosuria by inhibiting PNPase (purine nucleoside phosphorylase); however, mechanistic details are unknown. ...