Stéfanie Parisien-La Salle,Gregory L Hundemer,Matthew A Nehs et al.
Stéfanie Parisien-La Salle et al.
Primary aldosteronism (PA) is a common cause of hypertension, characterized by renin-independent aldosterone production that drives inappropriate mineralocorticoid receptor activation, sodium retention, volume expansion, and potassium wasti...
Ultrasound-Targeted Ablation of the Aortorenal Ganglion in Canine Model for Hypertension Treatment [0.03%]
超声引导下肾动脉旁交感神经消融术治疗犬高血压模型的安全性及有效性研究
Qiaoqiao Li,Yake Lou,Teng Xu et al.
Qiaoqiao Li et al.
Background: Precisely map and ablate the aortorenal ganglion (ARG) using noninvasive ultrasound technology to evaluate therapeutic effects and mechanisms in hypertension and related organ involvement. ...
Stress Trajectory and Hypertension 2 to 7 Years After Delivery: A nuMoM2b-HHS Study [0.03%]
产后2至7年内的压力轨迹与高血压：nuMoM2b-HHS研究
Virginia R Nuckols,Bethany Barone Gibbs,Benjamin C Brewer et al.
Virginia R Nuckols et al.
Background: Adverse pregnancy outcomes (APOs) are associated with a higher risk of developing chronic hypertension. The objectives of this study were to determine whether patterns of perceived stress during and after preg...
BRISC Deficiency Drives Heart Failure by Regulating β-Catenin K63 Ubiquitination [0.03%]
BRISC通过调节β-catenin的K63位泛素化驱动心力衰竭
Lu Liu,Guang-Ming Ren,Chen Chen et al.
Lu Liu et al.
Background: Adverse cardiac remodeling and dysfunction are hallmarks of hypertensive heart failure, yet molecular mechanisms remain incompletely understood. K63-linked deubiquitination has emerged as a critical posttransl...
Reliable Detection of SGLT2 Protein by Knockout-Based Antibody Characterization [0.03%]
基于基因敲除的抗体亚型鉴定在SGLT2蛋白检测中的可靠性的研究
Takuo Hirose,Hiroki Ito,Akari Endo et al.
Takuo Hirose et al.
Background: SGLT2 (sodium-glucose cotransporter 2) mediates renal glucose reabsorption, and its pharmacological inhibition exerts cardio- and renoprotective benefits. Despite widespread clinical interest, reliable detecti...
Frailty Index Offers Greater Discrimination Than Age for Optimal Blood Pressure Targets: A Pooled Analysis of Two Randomized Trials [0.03%]
脆弱性指数比年龄更有利于确定最佳血压目标：两项随机试验的 pooled 分析
Yizhen Lyu,Wenming Bian,Yezhou Liu et al.
Yizhen Lyu et al.
Background: Contemporary hypertension guidelines emphasize individualized blood pressure (BP) management, often incorporating age; yet chronological age alone may be insufficient to guide optimal treatment. The frailty in...
Randomized Study of Antithrombin in Early-Onset Preeclampsia: KOUNO-TORI Study [0.03%]
抗凝血酶治疗早期子痫前期的随机对照研究(KOUNO-TORI研究)
Jun Takeda,Daisuke Tachibana,Atsuo Itakura et al.
Jun Takeda et al.
Background: In preeclampsia, prolonging pregnancy decreases the risks of fetal morbidity and death. This study aimed to evaluate the efficacy and safety of antithrombin in prolonging pregnancy early-onset severe preeclamp...
Interplay of Age and Sex With Clinic and Ambulatory Blood Pressure and Mortality [0.03%]
年龄和性别对门诊和 ambulatory 血压及死亡率的交互作用
Michael Böhm,Alejandro de la Sierra,Igor Schwantke et al.
Michael Böhm et al.
Background: To explore associations of clinic and 24-hour ambulatory blood pressure (BP) monitoring (ABPM) with cardiovascular death (CVD), parameters were modeled for age and sex in this large cohort in primary care. ...
Cold-Induced Hypertension as Life-Environment Disease in Winter: Focus on Data From Japan [0.03%]
寒冷诱发的高血压作为冬季生命-环境病——基于日本的数据
Kazuomi Kario
Kazuomi Kario
An increase in the rate of cardiovascular events (eg, myocardial infarction, stroke, heart failure) during the winter season has been reported worldwide, including Japan. As 1 contributor to the increase in cardiovascular risk during the co...
Contemporary Prevalence and Treatment Patterns Among US Adults With Apparent Treatment-Resistant Hypertension [0.03%]
美国成人难治性高血压的流行率和治疗模式
William B Earle,Nathan W Watson,Stephen P Juraschek et al.
William B Earle et al.
Background: Resistant hypertension is associated with adverse cardiovascular outcomes and mortality. In the past decade, management guidelines have shifted to target lower blood pressures (BP). Current prevalence and pres...