Kif23 Promotes Myocardial Fibrosis by Suppressing Ces1d-Dependent Lipid Metabolism [0.03%]
Kif23通过抑制Ces1d依赖性脂质代谢促进心肌纤维化
Honghong Chen,Jie Xu,Qiuyuan Huang et al.
Honghong Chen et al.
Background: Myocardial infarction (MI)-induced ischemia leads to abnormal ventricular remodeling and cardiac fibrosis, which can ultimately progress to heart failure. Kif23 (kinesin-like protein 23) has been implicated in...
Ane Cecilie Westerberg,Maren-Helene Langeland Degnes,Ina Jungersen Andresen et al.
Ane Cecilie Westerberg et al.
Background: Placental dysfunction, a key feature of preeclampsia, has been linked to altered placental release of proteins into the maternal circulation. However, the identity of placenta-derived proteins in preeclampsia ...
MBNL1 Modulates Nek7 to Facilitate Pathological Cardiac Hypertrophy via NLRP3 [0.03%]
MBNL1通过NLRP3调节Nek7促进病理性心脏肥大
Chao Li,Xiaona Wang,Ruonan Yang et al.
Chao Li et al.
Background: Hypertension-induced cardiac hypertrophy constitutes the principal cause of heart failure, malignant arrhythmias, and sudden cardiac death. Nek7 (never in mitosis gene A [NIMA] related protein kinase 7), a mem...
Large Language Model Agent for Managing Patients With Suspected Hypertension [0.03%]
管理疑似高血压患者的大型语言模型代理
Yijun Wang,Wuping Tan,Siyi Cheng et al.
Yijun Wang et al.
Background: The effectiveness of Large Language Model agent frameworks for hypertension screening and personalized health management has not been fully studied. This study aimed to develop and evaluate a Large Language Mo...
Systolic Blood Pressure Time in Target Range and Acute Kidney Injury in Patients With Hypertension [0.03%]
高血压患者的血压达标时间与急性肾损伤的关系
Wei-Hua Chen,Cheng Yang,Yi-Tian Chen et al.
Wei-Hua Chen et al.
Background: Acute kidney injury (AKI) is a serious complication of hypertension management. However, the association between systolic blood pressure (SBP) time in target range (TTR) and the risk of AKI remains unclear. ...
Blood Pressure Genetics in Han Taiwanese With Cross-Trait Analysis in East Asians: Insights Into Comorbidities, All-Cause Mortality, and Cardiovascular Mortality [0.03%]
东亚人群中的血压遗传学及跨性状分析：对共病、全因死亡率和心血管疾病死亡率的新认识
Ying-Ju Lin,Ju-Pi Li,Yi-Ching Lai et al.
Ying-Ju Lin et al.
Background: Hypertension is a major health burden in East Asia. However, the genetic architecture and clinical implications of blood pressure (BP) traits remain underexplored beyond European-focused studies. This large-sc...
Life-Course Burden of Blood Pressure Is Associated With Midlife Cognitive Function [0.03%]
血压一生累积负担与中年认知功能相关
Wei Chen,Changwei Li,Ruiyuan Zhang et al.
Wei Chen et al.
Background: We aimed to examine relationships between cumulative life-course burdens and trajectories of cardiovascular risk factors and midlife cognitive function in a longitudinal cohort of the Bogalusa Heart Study. ...
Exacerbation of Dahl SS Hypertension and Renal Damage by NOX2 in CD4+ T Cells [0.03%]
NOX2诱导的CD4⁺T细胞在Dahl盐敏感型高血压及其肾损伤中的作用机制研究
Samuel D Walton,Emily C Burns-Ray,John Henry Dasinger et al.
Samuel D Walton et al.
Background: Infiltration of T cells into the kidney of Dahl salt-sensitive (SS) rats accompanies SS hypertension and renal damage. Genetic deletion of T cells on the SS background (knockout of the CD247 gene in Dahl salt-...
Blood Pressure 15 to 90 Days After a Hypertensive Disorder of Pregnancy and Later Hypertension [0.03%]
妊娠高血压疾病后15至90天的血压与之后的高血压风险关系研究
Rachel Peragallo Urrutia,Matthew Shane Loop,Jasmine D Johnson et al.
Rachel Peragallo Urrutia et al.
Background: Timely diagnosis of hypertension provides an opportunity for cardiovascular disease prevention after a hypertensive disorder of pregnancy. We assessed the association between blood pressure 15 to 90 days postp...
Inducible Endothelial Gch1 Deletion Reveals Rapid, Sex-Specific Effects on Blood Pressure and Pregnancy Outcomes [0.03%]
条件性删除内皮细胞GCH1基因对血压及妊娠结局的快速、性别特异性影响
Surawee Chuaiphichai,Desson Au-Yeung,Christopher A R Whiteman et al.
Surawee Chuaiphichai et al.
Background: Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide synthase. Constitutive endothelial BH4 deficiency leads to mild hypertension and vascular dysfunction that are partly compensated...