Ovariectomy Via 12/15-lipoxygenase Augments Angiotensin II-Induced Hypertension and Its Pathogenesis in Female Mice [0.03%]
12/15-脂氧合酶介导的卵巢切除通过增强雌性小鼠血管紧张素Ⅱ致高血压及其发病机制的作用大小
Shubha R Dutta,Purnima Singh,Kafait U Malik
Shubha R Dutta
Background: Ang II (angiotensin II) releases arachidonic acid from tissue phospholipids that is metabolized by 12/15-lipoxygenase (ALOX15), generating 12(S)- and 15(S)-hydroxyeicosatetraenoic acid (HETE), which have been ...
Efficacy of Antihypertensive Drugs of Different Classes After Renal Denervation in Spontaneously Hypertensive Rats [0.03%]
肾交感神经消融后不同类别的降压药物在 SHR 中的疗效研究
Mathias Hohl,Lucas Lauder,Özlem Sevimli et al.
Mathias Hohl et al.
Background: Renal denervation (RDN) lowers blood pressure (BP) in patients with uncontrolled hypertension. Limited data exist on the effectiveness of different antihypertensive medications following RDN on BP and maladapt...
Activin Receptor-Like Kinase 3 Directly Couples Gαq (Guanine Nucleotide-Binding Protein Subunit αq)/ Gαq (Guanine Nucleotide-Binding Protein Subunit α11) to Regulate Vascular Contractility [0.03%]
活化素受体样激酶3通过直接与Gαq/Gα11偶联调控血管收缩功能
Zeyu Cai,Nan Xie,Ze Gong et al.
Zeyu Cai et al.
Background: Vascular smooth muscle cell (VSMC) contractility is critical for blood pressure regulation and vascular homeostasis. Identifying the key molecule that maintains VSMC contractility may provide a novel therapeut...
Pediatric Primary Hypertension: An Underrecognized Condition: A Scientific Statement From the American Heart Association [0.03%]
美国心脏协会科学声明：儿童原发性高血压：一个被忽视的疾病状况
Bonita Falkner,Samuel S Gidding,Carissa M Baker-Smith et al.
Bonita Falkner et al.
The overall prevalence of hypertension in childhood is 2% to 5%, and the leading type of childhood hypertension is primary hypertension, especially in adolescence. As in adults, the leading risk factors for children with primary hypertensio...
Associations of Urine Biomarkers of Kidney Tubule Health With Incident Hypertension and Longitudinal Blood Pressure Change in Middle-Aged Adults: The CARDIA Study [0.03%]
中年人肾脏近端小管功能与高血压发病及血压变化的相关性：CARDIA研究
Muhammad B Khan,Rebecca Scherzer,Cora E Lewis et al.
Muhammad B Khan et al.
Background: Urine biomarkers of kidney tubule injury associate with incident hypertension in older adults with comorbidities, but less is known about these associations in younger adults. ...
Improved Persistence to Medication, Decreased Cardiovascular Events and Reduced All-Cause Mortality in Hypertensive Patients With Use of Single-Pill Combinations: Results From the START-Study [0.03%]
固定剂量单片复方制剂可提高高血压患者治疗依从性并减少心血管事件和全因死亡：START研究结果
Roland E Schmieder,Sven Wassmann,Hans-Georg Predel et al.
Roland E Schmieder et al.
Background: Single-pill combination improves adherence and persistence to medication in hypertension. It remains unclear whether this also reduces cardiovascular outcomes and all-cause mortality. We analyzed whether singl...
Transcriptomics-Based Subphenotyping of the Human Placenta Enabled by Weighted Correlation Network Analysis in Early-Onset Preeclampsia With and Without Fetal Growth Restriction [0.03%]
基于加权相关网络分析的子表型分型在妊娠早期子痫前期（伴有或不伴有胎儿生长受限）中的人胎盘转录组学分型
William E Ackerman th,Catalin S Buhimschi,Thomas L Brown et al.
William E Ackerman th et al.
Background: Placental disorders contribute to pregnancy complications, including preeclampsia and fetal growth restriction (FGR), but debate regarding their specific pathobiology persists. Our objective was to apply trans...
Methylation-Based Biological Age and Hypertension Prevalence and Incidence [0.03%]
基于甲基化的生物年龄与高血压的患病率和发病率的关系
Jacob K Kresovich,Dale P Sandler,Jack A Taylor
Jacob K Kresovich
Background: Hypertension is common in older individuals and is a major risk factor for cardiovascular disease. Blood DNA methylation profiles have been used to derive metrics of biological age that capture age-related phy...
Sleep Irregularity Is Associated With Hypertension: Findings From Over 2 Million Nights With a Large Global Population Sample [0.03%]
睡眠不规律与高血压相关：来自超过200万个夜晚的大型全球人群样本的研究发现
Hannah Scott,Bastien Lechat,Alisha Guyett et al.
Hannah Scott et al.
Background: Irregularities in sleep duration and sleep timing have emerged as potential risk factors for hypertension. This study examined associations between irregularity in sleep duration and timing with hypertension i...
Chronic Hypertension in Pregnancy: A Lens Into Cardiovascular Disease Risk and Prevention [0.03%]
妊娠期慢性高血压：心血管疾病风险和预防的研究窗口
Natalie A Cameron,Ian K Everitt,Kristen A Lee et al.
Natalie A Cameron et al.
Hypertension is a major, modifiable risk factor for cardiovascular disease (CVD) in the United States. Over the past decade, the prevalence of chronic hypertension (CHTN) during pregnancy has nearly doubled with persistent race- and place-b...