Current and Novel Biomarkers for Diagnosis and Subtyping of Primary Aldosteronism [0.03%]
原发性醛固酮增多症的诊断和分型的现行及新型生物标志物
Christina Pamporaki,Anna Angelousi,Jacques W M Lenders et al.
Christina Pamporaki et al.
Primary aldosteronism is a common and potentially curable cause of secondary hypertension, yet it remains substantially underdiagnosed. Current diagnostic pathways rely on the aldosterone-to-renin ratio, confirmatory tests, and subtype clas...
Timothy M Markman,Saman Nazarian,David S Frankel et al.
Timothy M Markman et al.
Resistant Hypertension Variants Link to Hyperaldosteronism and Potassium Levels [0.03%]
抗高血压变异与醛固酮增多症和钾水平相关
Vinicius Tragante,Patrick Sulem,Gudmar Thorleifsson et al.
Vinicius Tragante et al.
Background: We aimed to characterize the genetic architecture of resistant hypertension (rHTN), which affects up to 18% of hypertensive individuals and increases cardiovascular disease risk. ...
Systemic Extracellular Vesicles in Severe Early-Onset Preeclampsia Inhibit Angiogenesis in a Dose-Dependent Manner [0.03%]
系统外泌体以剂量依赖性方式抑制重度早发型子痫前期的血管生成
Scout Bowman-Gibson,Traci M Rackett,Hannah M DeRespiris et al.
Scout Bowman-Gibson et al.
Background: Extracellular vesicles have been shown to be elevated in preeclampsia and capable of effecting endothelial cell dysfunction. Severe early-onset preeclampsia is a major pregnancy-specific condition and is stron...
Early DOCA-Salt Hypertension Develops Without Increases in Renal or Lumbar Sympathetic Nerve Activity [0.03%]
早期DOCA盐高血压并未增加肾 sympathetic nerve activity 或腰部 sympathetic nerve activity
Misa Yoshimoto,Kenju Miki
Misa Yoshimoto
Background: Excessive salt intake is a major contributor to hypertension; however, the role of sympathetic nerve activity (SNA) remains controversial. Most existing evidence relies on indirect markers or single-time-point...
Boyao Chen,Meng Li,Tao Chen et al.
Boyao Chen et al.
Background: Preeclampsia is associated with long-term cognitive dysfunction, potentially linked to cerebral iron deposition. This study investigated striatal iron alterations using quantitative susceptibility mapping and ...
Yotam Ophir,Dror Walter,Patrick E Jamieson et al.
Yotam Ophir et al.
Changes in Retinal Microvasculature During Healthy Pregnancy Measured by AO [0.03%]
利用自适应光学技术测量健康孕妇视网膜微血管的变化
Anne Dathan-Stumpf,Emilie Martini,Holger Stepan et al.
Anne Dathan-Stumpf et al.
Background: Adaptive optics retinal imaging (rtx1e, Imagine Eyes, Orsay, France) enables high-resolution visualization of the retinal microvasculature, providing insights into systemic vascular health. Currently, no studi...
Longitudinal Maternal IgG and IgA Glycosylation Profiles in Pregnancy Reveal Early Immune Alterations in Placenta-Related Complications: The Rotterdam Periconception Cohort [0.03%]
纵向母体IgG和IgA糖型谱在妊娠期间的变化显示了与胎盘相关并发症早期免疫变化：鹿特丹 peri-conception队列
Lotte W Voskamp,Melek Rousian,Anna Daniels et al.
Lotte W Voskamp et al.
Background: Placenta-related complications are major contributors to maternal and neonatal morbidity. Glycosylation modulates immunoglobulin function by altering molecular structure and receptor affinity. During pregnancy...
Yue Qiao,Zihan Sun,Eric L Harshfield et al.
Yue Qiao et al.
Background: Blood pressure (BP) variability (BPV) is associated with cardiovascular risk beyond mean BP. Whether first-line antihypertensive regimens differentially affect BPV and cardiovascular outcomes remains uncertain...