Balancing Blood Pressure Targets and Kidney Health: The Potential Risk of Kidney Disease Due to Concentric Arterial and Arteriolar Hypertrophy From Renin-Angiotensin-Aldosterone Inhibitors [0.03%]
血压目标与肾脏健康之间的平衡：肾素-血管紧张素-醛固酮系统抑制剂导致同心性动脉和动静脉肥厚从而引发肾病的潜在风险
Lucas Ferreira de Almeida,Ulrich Wenzel,A H Jan Danser et al.
Lucas Ferreira de Almeida et al.
Neural Upregulation of SGLT2-MAP17-PDZK1 Complex in Kidneys of Rats With Heart Failure [0.03%]
心力衰竭大鼠肾脏SGLT2-MAP17-PDZK1复合体的上调及其机制研究
Tapan A Patel,Hong Zheng,Kaushik P Patel
Tapan A Patel
Background: Congestive heart failure (CHF) is characterized by the activation of neurohumoral drive concomitant with avid fluid retention. Renal denervation alleviates this fluid retention. SGLT2 (sodium-glucose cotranspo...
Blood Pressure Polygenic Score Predicts Long-Term Blood Pressure Control and Treatment-Resistant Hypertension [0.03%]
血压多基因评分预测长期血压控制及难治性高血压
So Mi Jemma Cho,Yunfeng Ruan,Hyeok-Hee Lee et al.
So Mi Jemma Cho et al.
Background: Suboptimal blood pressure (BP) control remains a major cardiovascular disease risk factor. Whether genetically predicted BP independently predicts long-term BP control is unknown. We examined the associations ...
Katie Williams,Benjamin Grobman,Fredrick Larbi Kwapong et al.
Katie Williams et al.
Background: Higher relative risk for cardiovascular disease (CVD) events at lower blood pressure (BP) thresholds in female versus male adults suggest that hypertension thresholds should be sex-specific. ...
Sanna Darvish,Kevin O Murray,Sophia A Mahoney et al.
Sanna Darvish et al.
Background: A later age at menopause (≥55 years) is associated with lower cardiovascular disease risk compared with a normal age at menopause (45-54 years) in postmenopausal women (PMW). Aortic stiffening increases cardi...
Efficacy and Safety of Treatment With Low Doses of Spironolactone in Patients With Primary Aldosteronism: A Retrospective Observational Study in a Tertiary Center [0.03%]
原发性醛固酮增多症患者小剂量螺内酯治疗的疗效和安全性：一家三级医疗中心的回顾性观察研究
Elisa Sconfienza,Julien Riancho,Nicole Gebara et al.
Elisa Sconfienza et al.
Background: Spironolactone is recommended as first-line therapy for patients with idiopathic primary aldosteronism. The aim of this study is to evaluate the impact of low and high doses of spironolactone on arterial blood...
Urokinase Promotes Redundantly Intratubular C3a-Formation But Not ENaC-Driven Hypertension in DOCA/Salt Kidney Injury [0.03%]
尿激酶在DOCA盐肾损伤中促进球内C3a的生成但不影响ENaC驱动的高血压
Marie Lykke Bach,Camilla Enggaard,Sai Sindhu Thangaraj et al.
Marie Lykke Bach et al.
Background: uPA (urokinase-type plasminogen activator) inhibitors mitigate salt retention, plasmin, and complement activation in acute proteinuric kidney diseases. We hypothesized that in chronic kidney injury with albumi...
Yi-Bang Cheng,De-Wei An,Dong-Yan Zhang et al.
Yi-Bang Cheng et al.
Background: The ambulatory arterial stiffness index (AASI) is increasingly used in clinical research and practice. This individual-participant meta-analysis aims to consolidate the prognostic accuracy of AASI in the gener...
Atrial Strain Outperforms Ventricular Strain for Detecting Hypertensive HFpEF Using CMR Feature Tracking [0.03%]
基于CMR特征跟踪的高血压HFpEF诊断中房缩期应变优于室缩期应变
Zhen Wang,Yuncheng Li,Yong Cheng et al.
Zhen Wang et al.
Background: Heart failure with preserved ejection fraction (HFpEF) accounts for ≈50% of heart failure, and hypertension often coexists. Although strain imaging detects subclinical dysfunction, the relative diagnostic val...
Circulating MALAT1 in Preeclampsia and Association With Cardiometabolic Risk [0.03%]
循环MALAT1在子痫前期的血清中的浓度及与心血管代谢风险的关系
Tove Lekva,Monica Frøystad,Annika E Michelsen et al.
Tove Lekva et al.
Background: Preeclampsia is a hypertensive disorder affecting 2% to 8% of pregnancies. Women with a history of preeclampsia have an increased risk of cardiovascular disease. The long noncoding RNA MALAT1 is shown to regul...