Iron Overload-Induced Ferroptosis Drives Placental Dysfunction in Preeclampsia [0.03%]
铁过载诱导的胎盘细胞新型焦亡在子痫前期发病机制中的作用研究
Yike Yang,Haoyu Zuo,Xiaojuan Ma et al.
Yike Yang et al.
Background: Preeclampsia, a life-threatening hypertensive disorder of pregnancy, has been linked to iron dysregulation, though mechanistic insights remain limited. ...
Hypertension in Patients With End-Stage Kidney Disease Requiring Dialysis: Bridging the Divide Between Evidence and Practice [0.03%]
终末期肾病需要透析患者高血压的治疗：如何缩小指南与实践之间的差距
Laura Mayeda,Nisha Bansal
Laura Mayeda
Hypertension is a highly prevalent and modifiable risk factor, affecting >80% of patients undergoing dialysis. Its pathophysiology is complex and differs from that of the general population, driven by factors such as volume overload, arteri...
Estimating the Potential Impact of the 2024 UK Salt Reduction Targets on Cardiovascular Health Outcomes and Health Care Costs in Adults: A Modeling Study [0.03%]
2024年英国减盐目标对成人心血管健康结局和医疗费用潜在影响的评估：基于模型的研究
Lauren Bandy,Ben Amies-Cull,Madison Luick et al.
Lauren Bandy et al.
Background: Excessive sodium intake is responsible for 3 million deaths a year globally. The UK is one of 64 countries to have a salt reduction program to help reduce the population's sodium intake. It is a voluntary sche...
Seated Saline Suppression Test for Lateralizing Primary Aldosteronism [0.03%]
坐位盐水抑制试验 lateralize 肾上腺醛固酮瘤起源
Alexander A Leung,Raj S Padwal,Gregory L Hundemer et al.
Alexander A Leung et al.
Background: Confirmatory testing to identify lateralizing primary aldosteronism (PA) is of uncertain benefit. Methods: Blinded clinical...
From French Gastronomy to Cardiovascular Health: Cutting Salt in the Baguette Has Saved Thousands of Lives in France [0.03%]
从法国美食到心血管健康：减少面包中的盐分在法国挽救了数千生命
Clémence Grave,Laure Carcaillon-Bentata,Christophe Bonaldi et al.
Clémence Grave et al.
Efficacy and Safety of Finerenone in Patients With Primary Aldosteronism: A Multicenter Prospective Study [0.03%]
FINERENONE治疗原发性醛固酮增多症患者的有效性和安全性：一项多中心前瞻性研究
Ping Li,Fan Yang,Yuxing Lou et al.
Ping Li et al.
Background: Finerenone is a novel nonsteroidal mineralocorticoid receptor antagonist. However, robust evidence about its efficacy and safety in primary aldosteronism is scarce. ...
Association of Clinic Blood Pressure and Out-of-Clinic Blood Pressure Difference With Falls Among Older Adults With Hypertension [0.03%]
诊室血压和非诊室血压差异与老年高血压患者跌倒的关系
Daichi Shimbo,C Barrett Bowling,Kimberly Cannavale et al.
Daichi Shimbo et al.
Background: A barrier to intensification of antihypertensive medication among older adults with hypertension is the perceived risk of falls. Blood pressure (BP) measured in the clinic setting is primarily used to decide w...
Development and Characterization of a Novel Chronic Thromboembolic Pulmonary Hypertension Rat Model: Identifying Sell-Podxl as Potential Regulators [0.03%]
一种新型慢性肺血栓栓塞性肺动脉高压大鼠模型的建立与鉴定SELL-PODXL为潜在调节因子
Jixiang Liu,Lin Hou,Jie Yang et al.
Jixiang Liu et al.
Background: Chronic thromboembolic pulmonary hypertension is characterized by proximal pulmonary artery obstruction and distal microvasculopathy. However, the mechanisms driving this dual-compartment pulmonary vascular re...
Takeshi Fujiwara,Satoshi Hoshide,Kazuomi Kario
Takeshi Fujiwara
Background: Nocturnal blood pressure (BP) is a better predictor of health outcomes than office or daytime BP. However, the clinical significance of nocturnal hypertension in patients of very advanced age remains unexplore...
Finerenone Improves Albuminuria via MR-TRPC Signaling in Diabetic Kidney Disease [0.03%]
糖尿病肾病中Finerenone通过MR-TRPC信号通路改善尿蛋白水平
Tsukasa Iwakura,Kengo Kidokoro,Rie Tatsugawa et al.
Tsukasa Iwakura et al.
Background: Recent studies have confirmed the protective effects of nonsteroidal MR (mineralocorticoid receptor) antagonists in diabetic kidney disease. However, the physiological mechanisms underlying their albuminuria-r...