Association Between Postprandial Hypotension Determined by Ambulatory Blood Pressure Monitoring and Falls Among Older Adults With Hypertension Who Are Taking Antihypertensive Medication: Results From the AMBROSIA Study [0.03%]
基于动态血压监测的餐后低血压与高血压服药老年人跌倒的关系：AMBROSIA研究结果
Keisuke Narita,C Barrett Bowling,Kimberly Cannavale et al.
Keisuke Narita et al.
Background: Postprandial hypotension (PPH) may contribute to falls among older adults, particularly those taking antihypertensive medication. However, evidence on this association in community-dwelling populations is limi...
Sex-Specific Blood Pressure and Brain Microvascular Traits in a Model of Low-Renin Hypertension [0.03%]
低肾素高血压模型中的性别特异性血压和脑微血管特征
T Michael De Silva,Rasna Sabharwal,Thomas D Gerhold et al.
T Michael De Silva et al.
Background: Hypertension is a leading risk factor for negative health outcomes due to end-organ effects that include small vessel disease in the brain. Low-renin hypertension is understudied at the blood pressure (BP), mi...
Concordant and Discordant Transcriptomic Signatures of Twin Placentas in the Setting of Preeclampsia [0.03%]
子痫前期双胞胎胎盘的转录组谱系特异性变化
William E Ackerman th,Irina A Buhimschi,Hongwu Jing et al.
William E Ackerman th et al.
Background: Multifetal pregnancies have increased preeclampsia risk, but the underlying pathogenesis may differ from that of singletons. It remains unclear whether twin placentas show molecular signs of preeclampsia synch...
C-Type Natriuretic Peptide Preserves Vascular and Cardiac Function in Sepsis [0.03%]
C型利钠肽可保持脓毒血症中的血管和心脏功能
Amie J Moyes,Claire Sand,Leanne Young et al.
Amie J Moyes et al.
Background: Sepsis is a life-threatening condition and a major cause of mortality in intensive care units worldwide, a clear unmet medical need. CNP (C-type natriuretic peptide) regulates inflammation and cardiovascular h...
Loss of ROR2 Tyrosine Kinase Receptor Is Associated With Endothelial Dysfunction in PAH via Inappropriate Integrin β1 Activation [0.03%]
ROR2酪氨酸激酶受体的丢失通过不适当的整合素β1激活与肺动脉高压相关的内皮功能障碍
Ankita Mitra,Stuti Agarwal,Ananya Chakraborty et al.
Ankita Mitra et al.
Background: Endothelial dysfunction is a key feature of pulmonary arterial hypertension (PAH). Previously, we demonstrated decreased Wnt7a transcript levels, causing reduced angiogenesis in PAH. Wnt7a expression correlate...
Endothelial LRRC8C Associates With LRRC8A and LRRC8B to Regulate Vascular Reactivity and Blood Pressure [0.03%]
内皮LRRC8C通过与LRRC8A和LRRC8B相互作用调控血管张力及血压
Qiujun Yu,Yonghui Zhao,Joshua Maurer et al.
Qiujun Yu et al.
Background: Endothelial mechanosensing is essential for controlling vascular tone. LRRC8A (leucine-rich repeat-containing protein 8A) was previously identified as a core subunit of the mechanoresponsive LRRC8 complex, fun...
Bacterial Extracellular Vesicles Mediate Microbiota-Host Communication to Regulate Blood Pressure in Male Rats [0.03%]
细菌外泌体介导的微生物群-宿主交流调控雄性大鼠血压
Huanan Shi,Feiya Shi,Rishi Wagle et al.
Huanan Shi et al.
Background: Altered gut microbiota composition has been implicated in the development of hypertension. Evidence suggests bacterial products and metabolites can enter circulation, act on peripheral tissues, and modulate bl...
Omonigho Aisagbonhi,Marni B Jacobs,Morgan Meads et al.
Omonigho Aisagbonhi et al.
Background: The placenta is known to be critical in the cause of preeclampsia. However, there is a subset of preeclampsia cases without identifiable placental pathology. We evaluated which clinical preeclampsia classifica...
Galectin-1 Is a Marker but Not a Mediator of Heart Failure With Preserved Ejection Fraction [0.03%]
岩藻糖结合型 lectin-1 是射血分数保留心力衰竭的标志物但不是其介导因素
Jean W Wassenaar,C Duncan Smart,Daniel J Fehrenbach et al.
Jean W Wassenaar et al.
Background: The immune system is emerging as a key player in driving cardiac remodeling in heart failure with preserved ejection fraction (HFpEF). Galectin-1 (Lgals1) is a carbohydrate-binding protein that we previously i...
Abnormal Proinflammatory Immune Cell Responses Precede Clinical Onset of Hypertensive Disorders of Pregnancy [0.03%]
妊娠高血压疾病的临床症状出现前免疫细胞异常的炎性反应现象
Ayman Rezk,Chelsea A DeBolt,Gautier Breville et al.
Ayman Rezk et al.
Background: Hypertensive disorders of pregnancy (HDP) are significant contributors to maternal morbidity and mortality, as well as to long-term cardiovascular health, with an inequitable burden among Black individuals. Wh...