Photoinduced Ligand-to-Metal Charge Transfer Enables Iron-Catalyzed Site-Selective Oxime Ether Construction at C(sp3)-H Bonds of Silanes [0.03%]
光诱导配体到金属的电荷转移促进铁催化硅烷C(sp3)−H键位点选择性羟胺醚化反应
Zhijun Hao,Xiushan Liu,Yunfei Cai et al.
Zhijun Hao et al.
Herein, we present a novel iron-catalyzed regioselective C-H functionalization of silanes for the construction of oxime ethers enabled by photoinduced ligand-to-metal charge transfer (LMCT). This transformation proceeds under mild condition...
Newcomer to the Calixarene Family: Synthesis and Characterization of Selenacalix[4]arene [0.03%]
新的_calix_［4］_:硒_calix_［4］_的合成与表征
Michal Churý,Tadeáš Petrů,Radek Staník et al.
Michal Churý et al.
In this work, we describe a general and efficient fragment condensation method for the synthesis of monoselenacalix[4]arene as a new member of the broad calixarene family. The key fragments were obtained from the starting p-tert-butylphenol...
Zhenhong Gan,Xiaoyan Cai,Liming Chen et al.
Zhenhong Gan et al.
Lanthanum-catalyzed tandem C(sp3)-H oxidation/spirocyclization under ambient conditions using molecular oxygen is reported. This method exhibits broad functional group tolerance and enables precise functionalization of complex scaffolds. Th...
Copper-Catalyzed Regio- and Enantioselective Acylation of 1,3-Enynes [0.03%]
铜催化1,3-烯炔的区域和对映选择性酰基化反应
Jing He,Wan Seok Yoon,Jaesook Yun
Jing He
This work discloses the first enantioselective copper-catalyzed acylation of 1,3-enynes with acyl fluorides. The reaction proceeds via an enantioenriched allenylcopper species that is chemoselectively generated from enynes in the presence o...
Copper/Nitroxyl-Catalyzed Oxidative Coupling of Methanol and Amines to Formamides [0.03%]
铜/亚硝基催化甲醇和胺氧化偶联生成酰胺类化合物反应
Hong-Yu Li,Hu-Cheng Yang,Hao-Xiang Hu et al.
Hong-Yu Li et al.
Methanol is a prominent basic C1 synthon in organic synthesis. Methods for direct coupling of methanol through C-N bond formation have limited precedents, despite their wide potential applications in organic and medicinal chemistry. Herein,...
Breaking the Density-Thermal Stability Trade-Off: Targeted Design and Construction of an Energetic Co-crystal [0.03%]
打破密度与热稳定性之间的取舍关系：能量共晶物的靶向设计和构筑
Ru-Yi Lu,Shuaijie Jiang,Kejing Zhang et al.
Ru-Yi Lu et al.
Achieving both high density and thermal stability remains challenging in energetic materials. This work presents a targeted co-crystal (DHANP·2HClO4) prepared via molecular self-assembly. It exhibits a density of 2.03 g cm-3 and an onset d...
Canustatins A and B, Two Polyketides from Streptomyces canus NA07887 [0.03%]
来源于施氏利斯特氏菌NA07887的多肽类化合物canfstatinsA和B
Hao Guo,Zi Jian Jiang,Xing Yi Wang et al.
Hao Guo et al.
Canustatins A and B, two structurally novel polyketide metabolites, were isolated from the actinobacterium Streptomyces canus NA07887. Their structures were determined through comprehensive spectroscopic analysis, including NMR and HRESIMS,...
δ-Quaternary Amino Acids and Dihydroisoquinolones from the Addition of Laterally Lithiated Aryl Carboxylates to N-Sulfinyl Ketimines [0.03%]
N-磺基酮亚胺与横向锂化芳族羧酸加成产物中的δ-季氨酰胺和二氢异喹啉
Matthew W Reeves,Mariusz Krawiec,Scott Pennino et al.
Matthew W Reeves et al.
Lateral lithiation of aryl and heteroaryl 2-methyl carboxylic acids with LDA and subsequent addition of the dianions to N-tert-butanesulfinyl ketimines gives N-sulfinyl δ-amino acids with high diastereoselectivities. One-pot sulfinyl depro...
α-Selective Ring-Opening of Bicyclo[1.1.0]butanes to Access Spirocyclobutyl Lactams [0.03%]
选择性开环双环[1.1.0]丁烷合成螺环丁基内酰胺化合物
Qinglong Liu,Boyang Mu,Haina Zhao et al.
Qinglong Liu et al.
A variety of spirocyclobutyl lactams were conveniently prepared by the Brønsted acid-catalyzed α-selective ring-opening of bicyclo[1.1.0]butane (BCB) within 15 min under mild conditions without any photocatalysts, oxidants, metal catalyst...
Orthogonal Cleavage of the HMPB Linker from Solid Support Using HFIP [0.03%]
利用HFIP对固相支撑的HMPB连接线进行正交切割
Michael Desgagné,Dennis A Kutateladze,Bradley L Pentelute
Michael Desgagné
Hexafluoroisopropanol (HFIP) is widely used as a hydrogen-bond-donor solvent. Here we demonstrate that 4-(4-hydroxymethyl-3-methoxyphenoxy)butyric acid (HMPB), a commonly used linker for generating C-terminal carboxylic acid peptides, cleav...