KF and Diaryl Iodide Salt-Mediated Ring Opening of Silacyclobutanes with Carbon Disulfide and Amines to Generate 3-(Fluorosilyl)propyl Dithiocarbamates [0.03%]
通过碳化硫和胺开环生成3-（氟代硅基）丙基二硫代氨基甲酸酯的硅杂环丁烷的KF及 diaryliodonium 盐介导的开环反应
Jiaze Qin,Mangang Guan,Shuairan Wang et al.
Jiaze Qin et al.
An unprecedented strategy for the ring-opening transformation of silacyclobutanes using potassium fluoride and diaryliodonium salts has been developed. In this multicomponent reaction, silacyclobutanes undergo ring opening mediated by potas...
Photoinduced α-Amino Alkylation of Heterocyclic Compounds via Catalytic Electron Donor-Acceptor Complexes [0.03%]
光诱导的杂环化合物α-氨基烷基化催化电子给体-受体复合物
Zhi-Qiang Zhu,Wen-Yi Zhang,Qian-Qian Xu et al.
Zhi-Qiang Zhu et al.
Visible light activation enables unprecedented synthetic transformations but typically requires precious metal complexes or elaborate organic dyes to absorb visible light and initiate reactivity. Herein, we report a more general, efficient,...
Palladium/Norbornene-Catalyzed ortho-Alkoxycarbonylation of Aryl Iodides Enabled Directly by Chloroformates [0.03%]
氯化碳直接启用芳基碘的 palladium/norbornene 催化的间氧代烷氧基羰基化反应
Xiao-Lin He,Dan Liao,Jun-Hao Huang et al.
Xiao-Lin He et al.
We present a palladium/norbornene-catalyzed ortho-alkoxycarbonylation of aryl iodides utilizing simple chloroformates as efficient alkoxycarbonyl sources, enabling concomitant ipso-functionalization encompassing alkenylation, cyanation, hyd...
Synthesis of Bis-urea-Bridged Cyclopeptides via Stapling of Unprotected Peptides [0.03%]
通过未保护肽的连接合成双脲桥联环肽
Wenfang Xiong,Peiru Chen,Jinyao Liu et al.
Wenfang Xiong et al.
This work establishes a chemoselective peptide stapling method via bis-urea bridge formation between native amino groups, using diisocyanates as linchpin reagents. This protocol achieves macrocyclization across 19- to 41-membered rings thro...
Visible-Light-Driven B-to-C Atom Swap: Scalable Skeletal Editing Access to Benzimidazoles from Diazaborines [0.03%]
可见光驱动的B到C原子互换：从二氮杂硼化合物合成苯并咪唑的骨架编辑方法
Yonghong Yin,Jianjing Yang,Kelu Yan et al.
Yonghong Yin et al.
We report a practical and scalable boron-to-carbon atom swapping methodology that facilitates the efficient synthesis of benzimidazole-based drugs. This exogenous photocatalyst-free, visible-light-driven transformation is selective and cont...
Copper-Mediated Oxidative Chloro- and Bromodifluoromethylation of Aliphatic Alcohols [0.03%]
脂肪醇的铜介导的氧化氯化和溴二氟甲基化反应
Wen-Juan Yuan,Jia-Yi Shou,Feng-Ling Qing
Wen-Juan Yuan
The synthesis of chloro- and bromodifluoromethyl alkyl ethers remained a fundamental challenge in synthetic chemistry. Herein we report the efficient and direct synthesis of chloro- and bromodifluoromethyl alkyl ethers through copper-mediat...
Photoredox/Brønsted Acid-Catalyzed Asymmetric Difluoroalkylation/Rearrangement of Alkenylfurans [0.03%]
光红氧化/布朗斯特酸催化烯基呋喃的不对称二氟烷基化/重排反应
Kunlong Yang,Menghan Qin,Yurong Tang et al.
Kunlong Yang et al.
A catalytic asymmetric difluoroalkylation/rearrangement of alkenylfurans with difluoroalkyl sulfones and anilines has been developed. This method employs cooperative photoredox/Brønsted acid catalysis, enabling efficient and versatile synt...
Ting Zhang,Huateng Zhang,Li-Hong Wang et al.
Ting Zhang et al.
A library of 29 structurally diverse tripodal ligands sharing a tris(biphenyl)methane scaffold was constructed by Suzuki reactions of the common intermediate 1 and commercial halogenated phenols. Rapid screening was conducted for the ligand...
Red-Light-Driven Recyclable mpg-C3N4-Catalyzed Minisci Reaction: Access to Heterocycle-Substituted Bicyclo[1.1.1]pentanes [0.03%]
红光驱动的可回收mpg-C3N4催化的Minisci反应：杂环取代双环[1.1.1]戊烷的合成方法
Chenya Wang,Jianyang Dong,Yajun Sun et al.
Chenya Wang et al.
The first red-light-driven Minisci reaction of heteroarenes with a readily available BCP-derived redox-active ester (RAE) has been developed, employing mesoporous graphitic carbon nitride (mpg-C3N4) as a recyclable heterogeneous photocataly...
Copper-Catalyzed Radical Halocyclization of N-4-Pentenamides: Synthesis of Chloro- and Bromo-Substituted γ-Lactams [0.03%]
铜催化N-4-戊烯酰胺的亲电子环化反应：氯代和溴代γ-内酰胺的合成
Xinrong He,Hanyang Zhang,Nawaf Al-Maharik et al.
Xinrong He et al.
Halogenated γ-lactams are valuable synthetic targets, but efficient methods for accessing chloro- and bromo-substituted analogues remain elusive. Here we describe a copper-catalyzed radical halocyclization of N-4-pentenamides that enables ...