Copper-Catalyzed Stereoselective Synthesis of Fluorinated 1,3-Dienes via Sequential Iodine-Fluorine Elimination [0.03%]
铜催化立体选择性合成含氟1,3-丁二烯：连续的碘-氟消除反应
Lili Zhao,Chenyang Liu,Jinghong Zhang et al.
Lili Zhao et al.
We report a copper-catalyzed stereoselective synthesis of fluorinated 1,3-dienes from unactivated alkenes via base-promoted sequential iodine-fluorine elimination. This protocol leverages commercially available polyfluoroalkyl iodides and ...
O- and S-Functionalized 6-Selenabicyclo[3.2.1]octanes from Elemental Selenium and 4-Vinylcyclohexene [0.03%]
元素硒和4-乙烯基环己烯合成的O-和S-取代的含硒螺环化合物
Evgeny O Kurkutov,Semen Yu Gubal,Sergey V Zinchenko et al.
Evgeny O Kurkutov et al.
A highly stereo- and regioselective approach to O- and S-functionalized 6-selenabicyclo[3.2.1]octanes as new types of bicyclic organoselenium compounds is developed based on the iodine-mediated reaction of elemental selenium with 4-vinylcyc...
Divergent Synthesis of Highly Functional 3-Trifluoromethylated Dihydropyrroles and Pyrroles via 6π-Photocyclization [0.03%]
通过6π光环化发散合成高功能化的三氟甲基二氢吡咯和吡咯类化合物
Meiqiong Li,Yuping Zhu,Daohong Yu et al.
Meiqiong Li et al.
Presented herein is a solvent-directed selective synthesis of 3-trifluoromethylated dihydropyrroles and pyrroles based on the anaerobic or aerobic reaction of trifluoromethyl-substituted dienamines via 6π-photocyclization. The work provide...
Tetraphenylethylene-Functionalized Neutral Radicals for Near-Infrared Photothermal Conversion [0.03%]
用于近红外光热转换的四苯乙烯功能化中性自由基
Chuan Yan,Min Wang,Jing Fang et al.
Chuan Yan et al.
A series of all-twisted radicals (TTM-PTPEA, TTM-2PTPEA, and TTM-3PTPEA) have been designed and synthesized by introducing aniline-modified tetraphenylethene onto the side arm of the TTM core. These radicals feature a near-infrared (NIR) ab...
Strain-Release-Driven 1,3-Halo-hydroxylamination of Bicyclo[1.1.0]butanes Enabled by Anomeric Amide Reagents [0.03%]
anomeric酰胺试剂介导的应变释放驱动的桥环烯烃1,3-卤氧基氨基化反应
Xiujuan He,Wei Li,Ting Zhang et al.
Xiujuan He et al.
A catalyst-free, strain-release-driven 1,3-halo-hydroxylamination of bicyclo[1.1.0]butanes (BCBs) is reported. This strategy employs anomeric amide reagents (N-protected N-halo-O-activated hydroxylamines) as difunctionalization reagents, yi...
Divergent Total Synthesis of Diterpenoid Natural Products from Salvia miltiorrhiza [0.03%]
丹参二萜类天然产物发散式全合成
Ryan R Strickland,Jian-Bin Lin,Huck K Grover
Ryan R Strickland
Herein we report a divergent strategy culminating in the first total synthesis of five terpene natural products isolated from Salvia miltiorrhiza. This approach features efficient construction of a functionalized tetralin core, a scalable r...
Modular Synthesis of Heptagon-Embedded Polyarenes by Double Cyclizations with Pyrones-Derived Aryliodonium Salts [0.03%]
双环化反应制备含七元内环的稠环聚芳烃化合物
Cheng Pan,Xiaoting Liu,Limin Wang et al.
Cheng Pan et al.
Heptagon-embedded polyarenes have long been of great interest in the field of optoelectronic materials. Herein, we report a double-cyclization strategy for the synthesis of heptagon-embedded polyarenes via pyrones-derived aryliodonium salts...
Directed Evolution of Artificial Aldolase for Enantioselective Biosynthesis of 3-Hydroxy-Oxindoles [0.03%]
人工甘露醇醛缩酶的定向进化及其高对映选择性合成3-羟基氧吲哚化合物
Liangyu Feng,Jie Lei,Zhixi Zhu et al.
Liangyu Feng et al.
Enantioenriched 3-hydroxyoxindole scaffolds are prevalent in numerous natural products and exhibit significant biological activity. However, biosynthetic methods for their production remain relatively limited. Here, we report an enantiosele...
Biomimetic Total Synthesis of Dispirocochlearoids A-C and Related Ganoderma Meroterpenoid Dimers [0.03%]
仿生全合成脊孢木灵菌素及其类似二聚倍半萜化合物
Sheng-Jie Shi,Xu-Liang Liu,Lin Yang et al.
Sheng-Jie Shi et al.
The first total synthesis of the anti-inflammatory Ganoderma meroterpenoid dimers dispirocochlearoids A-C, along with five of their diastereomers─potential unreported natural products─has been accomplished using a convergent strategy that...
Rhodium-Catalyzed Regioselective C-H Amidation of Benzaldehydes with Dioxazolones: Weakly Coordinating Aldehyde as a Traceless Directing Group [0.03%]
铑催化弱配位醛作为可裂解导向基的苯甲醛的选择性C-H氨化反应
Jing-Wen Jia,Juan Fan,Xiao-Zuan Chen et al.
Jing-Wen Jia et al.
A rhodium-catalyzed C-H amidation of ortho/para-substituted benzaldehydes with dioxazolones has been developed to afford meta-substituted aromatic amides in moderate to good yields. This transformation proceeds via weakly coordinating aldeh...