Access to Five-Membered Silacycles via Pd-Catalyzed Heck-Type Coupling with Arylthianthrenium Salts [0.03%]
钯催化Pd催化与芳基噻蒽盐的Heck型偶联制五元硅杂环化合物
Jia-Quan Wang,Ze-Dong Li,Xiao-Xue Nie et al.
Jia-Quan Wang et al.
Here, we report the preparation of a series of dihydrosilole derivatives via a Pd-catalyzed Heck-type reaction by employing arylthianthrenium salts as the arylating reagent. The reaction features mild conditions, excellent functional group ...
Unlocking Oxidative Cross-Coupling between Four Nucleophiles: Synthesis of Spiropyrrolo[2,1- a]isoquinolines [0.03%]
四种亲核试剂的氧化交叉偶联反应：螺吡咯并[2,1-a]异喹啉类化合物的合成
Yong-Xing Tang,Jun Ma,Li-Sheng Wang et al.
Yong-Xing Tang et al.
The oxidative cross-coupling of four nucleophiles, while intriguing for concurrently forming multiple C(X)-C bonds by the removal of several C(X)-H bonds, remains challenging and underexplored. Herein, we report that the convergent integrat...
Tianhao Zhang,Shulei Pan,Carsten Bolm
Tianhao Zhang
Unsubstituted primary sulfinamidines are obtained from sulfenamides by iron-catalyzed NH transfer from a readily available, shelf-stable hydroxylamine triflic acid salt. The reaction operates under mild conditions and does not require an in...
Regioselective Allylic Aminoalkylation Enabled by Dual Chromium/Photoredox Catalysis [0.03%]
基于双铬/光氧化还原催化的区域选择性烯丙基氨基烷基化反应
Shiming Tong,Wenlong Wang,Fu Ye et al.
Shiming Tong et al.
A highly branch-regioselective allylic aminoalkylation reaction has been developed through dual chromium/photoredox catalysis, providing an economical and sustainable alternative to conventional methods that rely on noble transition metals,...
Modular One-Step Three-Component Synthesis of Vinyl Ethers by Benzoquinone Trapping of Vinyl Radicals [0.03%]
苯醌诱捕自由基的一锅法合成乙烯醚的研究
Lv-Yan Liu,Mei-Jun Zheng,Jia-Hao Zhou et al.
Lv-Yan Liu et al.
We describe an iron/amine synergistically catalyzed three-component protocol for the synthesis of vinyl ethers containing pyridine units. This method uses oxime esters, enals, and benzoquinones as readily accessible substrates, affording th...
Shengkai Chen,Ziying Qi,Ke Dong et al.
Shengkai Chen et al.
Microdroplet chemistry is reforming organic synthesis in a green and sustainable manner in recent years because of the unique catalytic and redox environment at the gas-liquid interface. Nitration, an important way of introducing nitro grou...
Iridium-Catalyzed γ-Hydro(hetero)arylation of α,β-Unsaturated Amides [0.03%]
铱催化α，β-不饱和酰胺的γ-(杂)芳基氢化反应
Shoki Asai,Yuta Akahori,Yasuharu Yoshimi et al.
Shoki Asai et al.
α,β-Unsaturated amides are versatile building blocks in organic synthesis; however, forging C-C bonds at the γ-position is considerably more challenging than conventional β-addition. Herein, we report an iridium-catalyzed γ-hydro(heter...
Rhodium(III)-Catalyzed Three-Component Diamination of Bicyclo[1.1.0]butanes via Nitrene Transfer [0.03%]
氮烯转移催化的桥环化合物三组分叠氮化反应合成铑(Initialized by Rhodium(III))
Shunle Hu,Lijuan Jv,Ruijie Mi et al.
Shunle Hu et al.
Rhodium-catalyzed three-component diamination of bicyclo[1.1.0]butanes (BCBs) has been realized for the synthesis of 1,1,3,3-tetrasubstituted cyclobutanes. This ring-opening reaction of BCBs is strain-release-driven, and the trivalent rhodi...
Jingyu Wang,Weiguo Wang
Jingyu Wang
Herein, we report a strategy for the rapid synthesis of N-triazolyl alkylamides via a KOtBu-promoted three-component reaction. The reaction proceeded via the cycloaddition of nitriles and azides in the presence of a base, followed by the ca...
Visible-Light-Mediated Cyclization of Enynes toward Medium-Sized Carbocycles with Copper Catalyst [0.03%]
铜催化烯炔的可见光介导环化反应制中等大小碳环
Hikaru Takahashi,Kyoka Maeda,Ayu Yokoyama et al.
Hikaru Takahashi et al.
The development of efficient methods for the construction of medium-sized carbocycles is extremely important in organic synthesis since many pharmaceutical agents contain these frameworks. Herein, we report an efficient strategy for the syn...