Copper-Catalyzed Enantioselective [1,3] O-to-C Rearrangement of Heteroaryl Alkyl Ethers [0.03%]
铜催化杂芳基醚的对映选择性[1,3]氧氮原子到碳原子重排反应
Junhao Zhang,Duo Zhou,Xiaonan Cui et al.
Junhao Zhang et al.
Herein, we extend a catalytic enantioselective dearomative [1,3] O-to-C rearrangement constructing C2 quaternary benzofuranones/3-oxindoles from readily accessible C3-heteroaryl alkyl ethers. The abundant Cu(II) salts with (S,S)-BOX were us...
Dispersion-Driven Ligand Design for Cu(II)/Bis(oxazoline)-Catalyzed Asymmetric IEDDA Reactions [0.03%]
铜(II)/双肟酯催化环加成反应中的分散驱动辅助剂设计
Feiyang Li,Minjie Bi,Lixin Cui et al.
Feiyang Li et al.
The strategic exploitation of attractive London dispersion interactions in asymmetric catalysis, while not without precedent, has yet to become a mainstream design principle. Herein, we report a dispersion-driven ligand strategy that simult...
Direct Dehydrogenation of Ethers to Vinyl Ethers by Decatungstate and Cobaloxime Dual Catalysis [0.03%]
双催化剂体系催化醚直接脱氢制乙烯基醚反应
Peiyu Yi,Yuchen Jiang,Xiangmin Tian et al.
Peiyu Yi et al.
Vinyl ethers are valuable intermediates in polymer and organic synthesis. Most existing routes require prefunctionalization and multiple steps, increasing complexity and reducing efficiency. Here we report a direct photocatalytic dehydrogen...
Iodide-Induced Reductive Radical Generation from Sulfonyl Diazonium Salts: A Metal-Free Iodosulfonylation of Alkynes for (E)-β-Iodovinyl Sulfones Synthesis [0.03%]
金属催化-free通过联芳基碘
Qian Yan,Qun-Huai Zhou,Yang Li et al.
Qian Yan et al.
A metal-free halosulfonylation of alkynes using sulfonamides and tBuONO enables (E)-β-halovinyl sulfone synthesis. Control experiments and DFT calculations support a sulfonyl radical mechanism involving SET between diazonium intermediates ...
Fe(III)-Promoted ortho-Selective C-H Borylation of Aryl Selenoesters [0.03%]
联硒酸酯的邻位选择性C-H硼化反应研究及相关催化机理探索
Kai Yang,Shen Shan,Ping Li et al.
Kai Yang et al.
Herein, a novel protocol for the Fe(OTf)3-promoted ortho-selective C-H borylation of aryl selenoesters is described. The corresponding borylated selenoesters are obtained with excellent site selectivity in moderate to good yields under mild...
Rh-Catalyzed Cycloaddition Cascade of Allenynes and Maleimides: A Powerful Strategy for Constructing Complex Pentacyclic Structures with a Bicyclo[2.2.2]octene Core [0.03%]
铑催化炔亚胺与马来酰亚胺的环加成串联反应：构建含 bicyclo[2.2.2]辛烯核心复杂五环骨架的有效策略
Elias A Romero-Cavagnaro,Albert Artigas,Anna Pla-Quintana et al.
Elias A Romero-Cavagnaro et al.
Herein, we report that 1,5- and 1,6-allenynes react with two equivalents of maleimide to afford pentacyclic frameworks featuring a bicyclo[2.2.2]octene core in a fully diastereoselective fashion. DFT calculations and deuterium-labeling stud...
Access to Pyrazolo[1,5- a]pyrimidinone Regioisomers from Acylated Meldrum's Acids [0.03%]
N-乙酰化梅尔德姆酸的 regioisomer 吡唑并[1,5-a]嘧啶酮衍生物的合成与晶体结构
Maxime Donzel,Erik Chorell
Maxime Donzel
Two complementary and efficient methods for the regioselective synthesis of functionalized pyrazolo[1,5-a]pyrimidinones were developed from 3-aminopyrazoles and acylated Meldrum's acids. Fine-tuning the reaction conditions enables selective...
Oniya L Valencia,Peter Q Burleson,Karl A Scheidt
Oniya L Valencia
Arylethylamines are privileged motifs in bioactive compounds and pharmaceuticals. Described here is a novel photocatalytic aminoarylation of styrenes to afford arylethylamines utilizing commercially available reagents. Aryl iodides undergo ...
Harnessing Pnictogen and Chalcogen Bonding for Cross-Electrophile C-PIII Coupling of Chlorophosphines with Thianthrenium Salts [0.03%]
利用pnictogen和chalcogen键实现氯代磷与噻蒽鎓盐的交叉亲电子试剂交叉偶联反应
Gui-Ying Fu,He Sheng,Xiang Li et al.
Gui-Ying Fu et al.
While reductive C-P(III) cross-couplings have proven valuable for the synthesis of triarylphosphines, they often face challenges when applied to triarylphosphines bearing structurally complex aryl groups. Herein, we report an alternative an...
(3 + 2) Annulation of Cyclopropanone Acetal with Silyl Enol Ether toward the Synthesis of Polysubstituted Cyclopentanones [0.03%]
环丙酮缩醛与硅基烯醇醚反应合成多取代环戊酮化合物的研究
Yankun Zhao,Hongya Yan,Wang Xiang et al.
Yankun Zhao et al.
A (3 + 2) annulation to access the structurally diverse polysubtituted cyclopentanones bearing two adjacent quaternary stereogenic centers is reported. This reaction is proposed to proceed through a domino Mukaiyama aldol/homoaldol reaction...