Access to Axially Chiral Styrenes via Copper-Catalyzed Enantioselective Radical Relay Cyanophosphorylation of Alkynes [0.03%]
Wei Wang,Jichao Xiao,Xingwei Li
Wei Wang
A copper-catalyzed radical relay atroposelective phosphinoylcyanation of sterically hindered aromatic alkynes with phosphine oxides and trimethylsilyl cyanide has been established. This method provides efficient access to axially chiral sty...
Silong Chen,Kangfu Chen,Yanping Huo et al.
Silong Chen et al.
The cleavage of unstrained C-C bonds presents a significant challenge in synthetic chemistry. Herein, we disclose a visible light-induced aerobic ring-opening oxidation of unstrained aryl cycloalkanes using low-cost 2-bromoanthraquinone (2-...
Development of Nitro-Substituted Pyrido[1,2- a]indole Fluorophores for Environment-Sensitive Bioimaging [0.03%]
Jinju Kim,Taegwan Kim,Ji Soo Kang et al.
Jinju Kim et al.
We report the design and synthesis of a novel pyrido[1,2-a]indole fluorophore that exhibits deep-red emission (up to 660 nm), a large Stokes shift (6118 cm-1) in methanol, and excellent biocompatibility. Positional nitration enables systema...
Accessing CF3-Cyclopropenes ─ A Platform for the Synthesis of Trifluoromethylated Building Blocks [0.03%]
Wei Wu,Tobias M Milzarek,Matthew D Wodrich et al.
Wei Wu et al.
Cyclopropenes are the smallest unsaturated carbocycles. They possess exceptionally high ring strain, resulting in unique reactivity, enabling C═C bond functionalization and ring-opening transformations. Herein, we report a copper-mediated ...
Oxidation-Induced Scaffold Remodeling in Ainsliaea Disesquiterpenoids: Total Synthesis of Macrocephadiolide A [0.03%]
Kyriaki Gennaiou,Alexandros L Zografos
Kyriaki Gennaiou
Late-stage oxidations extend terpenoid architectures beyond cyclase-defined boundaries, driving molecular complexity and functional diversity. Disesquiterpenoid biosynthesis illustrates this, as simple monomeric carbocycles evolve into soph...
Cornelia H Warmutz,Ewgenij Proschak,Victor Hernandez-Olmos
Cornelia H Warmutz
Cannabioxepane, a recently described minor cannabinoid, remains largely unexplored pharmacologically due to its low natural abundance in Cannabis sativa. Previous synthetic approaches have yielded only limited quantities, necessitating the ...
Marva Tariq,Trevor W Butcher,Scott C Virgil et al.
Marva Tariq et al.
We report an approach to hypersampsone R that results in a 10-step synthesis of 6-epi-hypersampsone R, a polycyclic polyprenylated acylphloroglucinol (PPAP) possessing a rare bicyclo[3.3.1]nonane-2-8-dione core. This strategy includes a hig...
Electrochemical Synthesis of γ-Lactams from Amides and Alkenyl Trifluoroborates by [3 + 2] Annulation [0.03%]
Qian Liu,Wei Yi,Tianyu He et al.
Qian Liu et al.
Electrochemical [3 + 2] annulation of amides with alkenyl trifluoroborates has been achieved, using diphenyl sulfide as the mediator. This electrochemical method requires no base or external chemical oxidant and provides facile access to st...
Synthesis of Unsymmetrical C2,3-Bis-sulfenylated Indoles via Bimetallic Cu/Fe Relay Catalysis [0.03%]
Xiaohe Lu,Xiaoxiang Zhang,Fanghui Huang et al.
Xiaohe Lu et al.
The synthesis of unsymmetrical C2,3-bis(sulfenyl)indoles represents a significant challenge in heterocyclic chemistry due to the difficulty in controlling site-selective sequential functionalization. Herein, we report an efficient bimetalli...
Total Synthesis, Antibacterial Activity, and Structural Analysis of Atratumycin and Its Analogues [0.03%]
Yuya Sawayama,Rintaro Kaguchi,Motoko Shinohara et al.
Yuya Sawayama et al.
Solid-phase total synthesis of atratumycin (1) and its analogues is described. The linear depsipeptide was synthesized by the standard Fmoc solid-phase peptide synthesis, on-resin esterification, and epimerization-free macrolactamization. A...