Thiol-Ene Reaction of 1-Azabuta-1,3-dienes in Synthesis of Functionalized α-Amino Ketones and Fused Aziridines [0.03%]
通过1-氮杂丁二烯的硫醇-烯反应合成功能化的α-氨基酮和稠合氮丙啶
Nazar A Moshnenko,Gleb D Titov,Nikolai V Rostovskii
Nazar A Moshnenko
A cascade thiol-ene reaction of 3-acyloxy-1-azabuta-1,3-dienes, formed in situ from 1,2,3-triazolyl esters under Rh(II) catalysis, proceeds under mild conditions to give previously unknown α-amino-α'-sulfanyl ketones. The carboxylic group...
Thermodynamic Approach for Synthesizing [2]Catenanes from Borate Ion-Containing Crown Ethers and a Macrocyclic Ammonium Ion [0.03%]
一种以含硼酸盐冠醚和大环铵阳离子为原料合成[2]索烃的热力学方法研究
M Abdur Rahaman,Takumi Takizawa,Shinobu Miyagawa et al.
M Abdur Rahaman et al.
In this study, we synthesized [2]catenanes from bis-catechol spiroborate ion-containing crown ethers and a macrocyclic ammonium ion through hydrogen bonding and ion pairing. The borate-forming reaction of bis-catechol and trimethyl borate i...
Electrochemistry Facilitates the Chemoselectivity of Benzylic Alcohol Oxidations Mediated by Flavin-Based Photoredox Catalysis [0.03%]
电化学促进基于黄素的光氧化还原催化的苯基醇的选择性氧化
Rostislav Sponar,Alan Liška,Radek Cibulka
Rostislav Sponar
The use of oxygen for catalyst regeneration in photoredox catalysis causes selectivity problems, because the generation of reactive oxygen species initiates overoxidations and side oxidations. Herein, we present a system using the electroch...
Shimojilide, a Potent Potent and Selective Antiproliferative Cyclic Lipopeptide from a Marine Cyanobacterium Okeania sp [0.03%]
来自海洋_CYANOBACTERIUM_OKEANIA_属的强力增殖抑制环状脂肽抗生素_shimojilide
Mizuho Niiyama,Naoaki Kurisawa,Shingo Dan et al.
Mizuho Niiyama et al.
Shimojilide (1), a new cyclic lipopeptide, was isolated from a marine cyanobacterium Okeania sp. Its structure was elucidated by NMR and chemical derivatization, revealing a peptide-polyketide hybrid with a skipped diene and β-branched met...
Chromone-Thiocoumarin Transmutation Enabled by Lawesson's Reagent [0.03%]
硫醇缩氨茋化合物与色满类化合物的相互转换反应构建了Lawessons试剂
Yu-Chen Fang,Li-Ping Tu,Hui-Min Li et al.
Yu-Chen Fang et al.
Selective editing of molecular skeletons at specific atomic sites is a core strategy for lead compound discovery in medicinal chemistry. Herein, we report an efficient protocol for the skeletal transmutation of chromone derivatives to thioc...
Hui Liu,Longfei Han,Weijie Jiao et al.
Hui Liu et al.
The synthesis of carboxylic esters represents a pivotal transformation in organic chemistry owing to their widespread utility in pharmaceuticals, natural products, materials science, and fine chemicals. Traditionally, esterification by redo...
Unprecedented Meroterpenoids Exert Anti-inflammatory Activity by Targeting NF-κB and PI3K Signaling Pathways [0.03%]
前所未有的色满萜类化合物通过靶向NF-κB和PI3K信号通路发挥抗炎活性
Yuqian Tang,Die Yan,Chuxing Liang et al.
Yuqian Tang et al.
Four classes of unprecedented meroterpenoids (1-10), together with 10 new analogues, were isolated from the symbiotic fungi biotransformation extract. Among them, compounds 1-3 were characterized as the inaugural meroterpenoids containing a...
Synthesis of an A/B- cis-Fused Cyclopenta[ b]fluorene (6/5/6/5) Ring System for Embellicine A via the Eight-Membered Silylene-Tethered IMDA Reaction [0.03%]
通过八元硅烯连接的IMDA反应合成Embeline A的A/B-顺式融合环系( cyclopenta[ b]fluorene (6/5/6/5))
Yuya Sakai,Ryoma Murata,Akihiro Hirakawa et al.
Yuya Sakai et al.
The first synthesis of an A/B-cis-fused cyclopenta[b]fluorene (6/5/6/5) ring system was successfully achieved via an intramolecular Diels-Alder (IMDA) reaction of an eight-membered silylene-tethered precursor. In this key step, a significan...
Photocatalytic Radical Relay Strategy for the Synthesis of Allylic gem-Difluorides via 1,4-Difunctionalization of gem-Difluorobuta-1,3-dienes [0.03%]
通过gem-二氟丁烯的1,4-双官能化合成仲二氟烯丙基化合物的光催化自由基接力策略
Zhongyu Zhang,Shenting Xu,Luxuan Xu et al.
Zhongyu Zhang et al.
Fluorine-containing organic compounds are vital in bioactive molecules and materials, with allylic gem-difluorides as key motifs in drugs. Herein, we report an efficient photocatalytic strategy for the synthesis of allylic gem-difluorides u...
Orthogonal Electrochemical Amine Deprotection: Toward Sustainable Strategies for Peptide Synthesis [0.03%]
正交电化学胺脱保护：朝向肽合成的可持续策略
Esteban Suárez-Picado,Saurabh K Ahirwar,Lara R Malins
Esteban Suárez-Picado
Deprotection steps employed in peptide synthesis often require harsh conditions and excess reagents, limiting substrate compatibility and sustainability. Electrochemically cleavable protecting groups (e-PGs) offer an attractive alternative....