Xin-Lan Zhao,Hua Zhang,Da-Song Chen et al.
Xin-Lan Zhao et al.
We report a copper-catalyzed deaminative sp3 C-N cross-coupling of primary alkyl amines with N-heteroarenes, enabled by a deaminating reagent that generates alkyl radicals in situ. The method features general conditions, a broad substrate s...
Divergent Synthesis of α,β-Unsaturated γ-Lactams via Tunable C-H Annulation of Acrylic Acids with Imines [0.03%]
Xin Zhang,Linjun Qi,Yanting Shi et al.
Xin Zhang et al.
We have developed a tunable C-H annulation strategy for the divergent synthesis of α,β-unsaturated γ-lactams from acrylic acids and imines. A ruthenium-catalyzed, redox-neutral vinylic C-H addition/cyclization with in situ generated form...
Visible-Light-Enabled Sulfonyl Radical-Triggered Cyclization Strategy for the Efficient Synthesis of Benzosultams [0.03%]
Mithu Roy,Sanatjit Kar,Masthan Thamim et al.
Mithu Roy et al.
We introduce a green and practical visible-light-driven method to synthesize benzosultam derivatives using an eosin Y organophotocatalyst. Under ambient conditions, N-alkyl-N-propargyl arylsulfonamides react with sodium aryl sulfinates thro...
Tuning the Energy and Stability of Compounds by Functional Group Modification in 1,2,4-Triazole Derivatives [0.03%]
Hui Zhang,Suli Du,Dongshuai Su et al.
Hui Zhang et al.
Balancing the energy and stability is a key challenge in the design of energetic materials. In this work, a series of novel compounds were synthesized by introducing varying numbers of nitro groups through precise modifications to the 1,2,4...
Visible-Light Photoredox Catalysis: Enabling [2π+2σ] Dearomative Cycloaddition of Unactivated Indoles with Bicyclo[1,1,0]butyl Tethers [0.03%]
Shi-Ru Chen,Yu-Bo Xia,Qin-Hua Song
Shi-Ru Chen
Dearomative [2+2] photocycloadditions of indoles with unsaturated functionalities via the energy transfer (EnT) process have been the subject of extensive investigation. In this work, we developed a dearomative [2π+2σ] photocycloaddition ...
Yan Zhang,Hao Yang,Kai Li et al.
Yan Zhang et al.
Although C(sp3)-H bond arylation has been extensively investigated in synthetic chemistry, the direct diarylation of such bonds has scarcely been explored. Herein, we report an efficient electrophotochemical strategy for C(sp3)-H diarylatio...
Photocatalytic In Situ Media-Promoted Cascade for Direct Synthesis of Long-Chain Aryl Ketones via γ-C(sp3)-H Activation [0.03%]
Qiang Wang,Si-Hui Qiu,Xiang Zou et al.
Qiang Wang et al.
A novel photocatalytic strategy is described for carbonylative difunctionalization of unactivated γ-C(sp3)-H bonds with alkenes. Building on a reductively initiated radical pathway from N-O reagents in combination with a 1,5-hydrogen atom ...
Chemoselective [2+1] Cycloaddition of Difluorocarbene with Conjugated Enynes: Synthesis of Alkenyl Difluorocyclopropenes [0.03%]
Zhongyi Wang,Shuo Sun,Chuanfa Ni et al.
Zhongyi Wang et al.
The chemoselective [2+1] cycloaddition of difluorocarbene with conjugated enynes has been achieved. Using TMSCF2Br as the difluorocarbene precursor in the presence of a catalytic amount of n-Bu4N+Br-, the reaction proceeded smoothly in THF ...
Nitrogen-Doped Dehydrobenzoannulene as an Electron Acceptor Enabling Trace Epinephrine Analysis [0.03%]
Peng Xu,Huabi Xie,Yu Zuo et al.
Peng Xu et al.
Herein, utilizing dehydrobenzoannulene and azadehydrobenzoannulene as the acceptor, three electron donor-acceptor architectures were divergently synthesized. Intriguingly, benefiting from the nitrogen-doped skeleton, the corresponding aza d...
Photoexcited Copper-Catalyzed Atom Transfer Radical Addition (ATRA) Reaction of Unsaturated C-C Bonds with 1-Iodo- o-carboranes [0.03%]
Zhuo Chen,Zengqiang Liang,Zi-Teng Yang et al.
Zhuo Chen et al.
In photoinduced, radical-mediated carbon-terminus carborane functionalization, critical constraints include intricate substrate precursor synthesis, the requirement for ultraviolet light, and costly photosensitizers. This study employs cost...