Cu-Catalyzed One-Pot Synthesis of Trifluoromethylated β-Lactams by Reaction of Nitrosoarenes, Trifluorodiazoethane and Arylacetylenes [0.03%]
硝基芳烃，三氟叠氮乙烷和 arylacetylenes 反应合成三氟甲基β-内酰胺化合物
Usha Yadav,Sanoop P Chandrasekharan,Anamika Dhami et al.
Usha Yadav et al.
In this paper, we disclose the utility of trifluorodiazoethane in forging trifluoromethylated β-lactams through a streamlined, one-pot Cu-catalyzed reaction involving nitrosoarenes and alkynes. This process involves the in situ generation ...
Redox-Active Sulfonyl Hydrazones as Programmable Sulfur Transfer for Nickel-Catalyzed C-S Coupling with Organic Halides [0.03%]
红氧化学活性砜亚胺作为镍催化C-S偶联中可编程硫转移的底物研究
Binglian Yang,Liguang Ji,Hui Wang et al.
Binglian Yang et al.
The utilization of hydrazones as carbon or nitrogen sources in transition-metal-catalyzed synthetic chemistry has been well developed; however, their application as electrophilic sulfur cation surrogates remains uncharted territory. Herein,...
A Single Residue Switch Controls Isomer Selectivity in the Myxobacterial Isobonnadiene Synthase [0.03%]
一个单一残基的变化控制着黏细菌Isobonnadiene合酶的异构体选择性
Mohammed M A Ahmed,Jordan Nafie,Jeffrey D Rudolf
Mohammed M A Ahmed
Myxobacterial terpenoids are rare and only a few myxobacterial terpene synthases are known. A terpene synthase, IbdS, from Polyangium aurulentum sp. SDU3-1 was found to produce the Δ9,10 isomer (1) of the spirocyclic 6/7/5-tricyclic bonnad...
A Polarity-Mismatched Photocatalytic Cross-Coupling Enables Diversity-Oriented Synthesis of aza-Heterocycles [0.03%]
一种偶极性不匹配的光催化交叉偶联方法实现氮杂杂环化合物的多样性导向合成
Joanna Urbańczyk,Aidan P McKay,David B Cordes et al.
Joanna Urbańczyk et al.
Diversity-oriented synthesis (DOS) is an attractive approach for the design of functional molecules with (homo)allylic amines representing a particularly attractive DOS platform. Herein, we demonstrate the application of newly developed pho...
Max Schönenbroicher,Maximilian Seul,Simon Morgenschweis et al.
Max Schönenbroicher et al.
The synthesis of the western fragment of vancoresmycin was accomplished in a highly modular and stereoselective manner. Central to this strategy was a modified Cu-catalyzed β-boration protocol for α,β-unsaturated enones, which enabled co...
Regioselective 1,2-Diamination of Aryl-Substituted 1,3-Dienes via Axial PPh3-Coordinated Dirhodium(II) Catalysis [0.03%]
轴向PPh3配位的二铑(II)催化芳基取代的1,3-丁二烯1,2-二胺化反应区域选择性研究
Liang Zhang,Chuanyong Wang,Xinli Rong et al.
Liang Zhang et al.
Axial PPh3 coordination enables the regioselective 1,2-diamination of aryl-substituted 1,3-dienes using dirhodium catalysis, employing N-fluorobenzenesulfonimide as the oxidant and nitrogen source. This base-free protocol proceeds via a PPh...
Photochemical Ni-Catalyzed Enabled C-O Coupling of Aryl Halides with Phenols [0.03%]
光化学镍催化芳基卤化物与酚的C-O偶联反应
Chuhui Lai,Geyang Song,Xiaoli Shi et al.
Chuhui Lai et al.
The low nucleophilicity of phenol is a major obstacle in the transition metal-catalyzed synthesis of diaryl ethers. This work presents a mild and efficient strategy for C-O coupling between aryl halides with phenols without the need for an ...
H-Bond- and Strain-Release-Guided Photoreaction of Alkenes, p-Quinone Methides, and Ammonium Thiocyanate [0.03%]
氢键和张力释放导向的烯烃、ρ-甲基醌和硫氰酸铵的光反应
Jobsy Jose,Arun Yadav,Saumya Singh et al.
Jobsy Jose et al.
Spiro-cyclobutanes are sp3-rich molecules with applications in synthetic chemistry and drug discovery. The existing literature focuses mainly on their synthesis via the metal-catalyzed functionalization of substrates, such as spiro-cyclobut...
(Vinyl tosyloxy)benziodolium Salts: Divergent Construction of Conjugated Diene Derivatives via Sequential Coupling Reactions [0.03%]
苯碘
Cheng Pan,Hamza Khan,Xiaoting Liu et al.
Cheng Pan et al.
Using (vinyl tosyloxy)benziodolium salts, we divergently synthesized a series of conjugated diene derivatives with the Mizoroki-Heck reaction. Subsequent coupling reactions of these dienes provide access to polycyclic aromatic conjugated di...
Enantioselective Total Synthesis of Citrifelin A via the Oxa-Pictet-Spengler Reaction and Acid-Promoted Dihydropyran Formation [0.03%]
含有氧杂派克特-斯彭格勒反应和酸促进的二氢吡喃形成的柚叶碱A的不对称全合成
Kazuki Hori,Miyu Saito,Karen Shigeta et al.
Kazuki Hori et al.
The enantioselective first total synthesis of (-)-citrifelin A is described herein. We found that the oxa-Pictet-Spengler reaction and acid-promoted dihydropyran formation were effective for the stereocontrolled construction of the tetracyc...