Synthesis of the Threoglucin 1,3-Oxazinane Core via Cyclothreonine Rearrangement [0.03%]
环瑟奥닌重排生成三糖甘素1,3-恶嗪核心化合物
Natalia Cano-Sampaio,Juan R Del Valle
Natalia Cano-Sampaio
Cyclization of serine and threonine-containing N-hydroxy dipeptides under Mitsunobu conditions affords 1,3-oxazinanes via N-acylimine intermediates. Synthesis of the heterocyclic core of the threoglucin family of antibiotics proceeds in hig...
Methylalkylation of Unactivated Alkenes by Photoredox/Nickel Catalytic HAT and Radical Selectivity Control [0.03%]
未活化烯烃的光/镍催化甲基烷基化反应中的HAT及自由基选择性控制研究
Hui Zhang,Ying-Jie Wang,Hao-Wen Jiang et al.
Hui Zhang et al.
Herein, we report a strategy for the methylalkylation of unactivated alkenes via synergistic photoredox/nickel catalysis. This mild transformation employs di-tert-butyl peroxide (DTBP) as a bifunctional reagent, which serves simultaneously ...
Bingwei Hu,Xiao Zheng
Bingwei Hu
N-Benzyl amides are important structural motifs in pharmaceuticals and natural products. The nucleophilic substitution reactions between aromatic nucleophiles and N-acyliminium ion precursors (N-acyl hemiaminal derivatives) represent one of...
Organocatalytic Visible-Light-Driven Metallomimetic Charge Transfer Process: Application in C(sp3)-N Bond Formation [0.03%]
可见光驱动的有机小分子催化仿金属配合物电荷转移过程及其在C(sp3)-H键氨化的应用研究
Anukriti Singhal,Partha Pratim Sen,Sudipta Raha Roy
Anukriti Singhal
A visible-light-mediated metallomimetic charge transfer strategy for the amination of the inert C(sp3)-H bond of ethers has been demonstrated. This organocatalytic strategy utilizes a polyaromatic odd alternant hydrocarbon-based photocataly...
Bao-Ru Yuan,Xiao-Chu Wang,Zhihan Zhang et al.
Bao-Ru Yuan et al.
As an important class of compounds, silazanes serve as functional molecules in a variety of fields. Herein, we report a visible-light-induced radical-radical coupling of polysubstituted silanes with NHPI esters to achieve Si-N bond formatio...
Diastereo- and Enantioselective Nickel-Catalyzed Intramolecular Reductive Cyclization of Unactivated Alkenes and Aldehydes [0.03%]
未活化烯烃和甲醛的镍催化分子内还原环化反应的非对映和对映选择性研究
Xiao-Ya Sun,Xiang-Rui Liu,Ye-Wei Huang et al.
Xiao-Ya Sun et al.
Catalytic reductive coupling of unsaturated hydrocarbons with carbonyl compounds provides a streamlined alternative to stoichiometric organometallic additions, yet asymmetric variants that directly engage unactivated alkenes remain limited....
Mei Bai,Chaoqun Shi,Minghui Sun et al.
Mei Bai et al.
We present a NaHMDS-promoted method for the efficient and highly selective synthesis of aryl boronates from carbonyl compounds. This approach offers several advantages, including environmental sustainability, the absence of halogenated wast...
Rhodium-Catalyzed Formal C-H and X-H Insertion Reaction Involving an Exocyclic Vinylic Cation Intermediate [0.03%]
涉及exo-乙烯基阳离子中间体的铑催化C-H和X-H形式插入反应
Kemiao Hong,Shasha Chen,Jingxian Li et al.
Kemiao Hong et al.
The carbocation is one of the highly reactive intermediates in synthetic chemistry; however, catalytic selective transformations involving vinylic cation species remain elusive in comparison to sp2-hybrid ones. Herein, we report a Rh-cataly...
Morgane Delattre,Milena Wiegand,Qian Wang et al.
Morgane Delattre et al.
Under acidic conditions, propargylic alcohols undergo Meyer-Schuster or Rupe rearrangements to afford two isomeric α,β-unsaturated ketones. Herein, we disclose a mechanistically distinct base-mediated regioselective conversion of TMS ethe...
Regioselective C2-Sulfonylation of Indoles and Pyrroles via SO2 Insertions [0.03%]
经SO2插入的吲哚和吡咯的选择性C2-磺酰化反应
Rekha Bai,Wan-Lin Cheng,Chun-Yu Peng et al.
Rekha Bai et al.
A molecular iodine-catalyzed three-component cascade reaction of indoles/pyrroles, anilines, and DABSO has been developed, providing C2-sulfonylated indoles/pyrroles in good to excellent yields. The transformation proceeds via the in situ g...