Hyperacmoses A-C, Three Seco-Norpolyprenylated Acylphloroglucinols from Hypericum acmosepalum with Lipid-Lowering Activity [0.03%]
_hyperacmoses A-C，来自Hypericum acmosepalum的三种茋化合物及其降血脂活性
Zhuohan Hu,Lei Huang,Lang Wang et al.
Zhuohan Hu et al.
Hyperacmoses A-C, three seco-norpolyprenylated acylphloroglucinols (PPAPs) (1-3), along with two processors (4 and 5), were purified from Hypericum acmosepalum. Structurally, compounds 1 and 2 represent the first seco-norPPAP with an unprec...
Direct Benzylic Phosphination of Toluenes Enabled by a Heterobimetallic LiN(SiMe3)2/Cs2SO4 System [0.03%]
路易斯碱/锂杂双金属试剂催化的甲苯直接苄位磷化反应
Junyu Ma,Yan-En Wang,Yunfei Gao et al.
Junyu Ma et al.
Organophosphorus compounds hold significant importance in materials science, medicinal chemistry, and agrochemicals. However, their syntheses have mainly relied on transition metals and prefunctionalized substrates. To overcome these limita...
Ru(II)-Catalyzed Synthesis of Vinyl Sulfonates Using Acetylene as C2-Synthon [0.03%]
利用乙炔作为C2合成子催化合成乙烯基磺酸酯
Lin Chen,Yu Wang,Yang Chen et al.
Lin Chen et al.
A ruthenium-catalyzed addition of sulfonic acids to acetylene is reported. This method employs bulk industrial feedstock acetylene as C2 synthon under atmospheric pressure to access vinyl sulfonates in good to excellent yields without using...
Light Illuminates Polarity-Mismatched Cycloaddition to Convert Isoquinoliniums into Phenylnaphthyl Sulfones [0.03%]
光促进的极性相反的环加成反应将异喹啉
Yunlong Qin,Yuanyuan Zeng,Weihan Wang et al.
Yunlong Qin et al.
A visible-light-driven skeletal editing strategy that converts readily available isoquinolinium salts into phenylnaphthyl sulfones via a formal CN-to-CC atom-pair swap is presented. The process is triggered by an isoquinolinium-carbonate el...
Pd-Catalyzed Aqueous Buchwald-Hartwig Amination with Amphiphilic Polymer PEG-PVEG [0.03%]
两亲性聚合物PEG-PVEG催化的布劳沃德-哈特韦尔胺基化反应
Qiong Chai,Fengming Zhang,Minghang Wang et al.
Qiong Chai et al.
An efficient micellar palladium-catalyzed aqueous Buchwald-Hartwig amination has been developed, enabled by the self-assembly of amphiphilic copolymer polyethylene glycol-polyvinylethylene glycol (PEG-PVEG). Using 0.5 mol % BrettPhos-Pd-G3 ...
Enantioselective Synthesis of Medium-Sized Rings via a General Palladium-Catalyzed (6 + n) Annulation Platform [0.03%]
手性中环化合物的钯催化(6+n)环化反应构建新方法研究
Xuling Chen,Changzhen Zhai,Yan Guo et al.
Xuling Chen et al.
The catalytic construction of medium-sized rings, particularly in an enantioselective manner, remains a significant challenge due to inherent entropic penalties and stereocontrol issues, yet it is an area of great interest. Herein, we discl...
Yan-Xun Li,Wei-Ting Zhao,Yen-Ku Wu
Yan-Xun Li
Controlling regioselectivity in deprotonative arylation of conjugated carbonyl systems remains a longstanding challenge. We report a Pd-catalyzed γ'-arylation of cyclic vinylogous esters (CVEs), enabled by Pd(dba)2/cataCXium A and hexameth...
Ligand- and Temperature-Controlled Stereodivergent Nickel-Catalyzed Hydrophenoxylation of Ynamides [0.03%]
配体和温度可控的镍催化炔胺的对映选择性氢苯氧基化反应
Sofaya Joshi,Arijit Sahoo,Ponneri C Ravikumar
Sofaya Joshi
The controlled synthesis of both E- and Z-stereoisomers remains a long-standing challenge in organic synthesis, yet it is important for accessing structurally and functionally diverse enamides. This study demonstrates the synthesis of E- an...
Halide-Mediated Electrochemical Peptide Synthesis Applicable to Highly Sterically Hindered Amino Acids [0.03%]
适用于空间位阻氨基酸的卤化物介导的电化学肽合成方法
Shingo Shinjo-Nagahara,Goki Hiratsuka,Yohei Okada et al.
Shingo Shinjo-Nagahara et al.
Electrochemical peptide synthesis using triaryl phosphines has been shown to be a promising approach for reducing the amount of waste in peptide synthesis. However, there is room for improvement from the viewpoint of the substrate scope. In...
Iron-Catalyzed Photoredox Decarboxylative Hydroalkylation with Alkynes and Alkenes [0.03%]
铁催化光氧化还原脱羧氢烷基化反应合成茋类化合物：炔烃和烯烃反应性的比较研究
Zhenzhu Hu,Haoran Yuan,Yuxin Lin et al.
Zhenzhu Hu et al.
A photocatalyzed decarboxylative hydroalkylation approach has been developed, providing efficient and stereoselective access to synthetically challenging Z-configured allylamine derivatives from carboxylic acids and alkynes. The reaction is...