Tertiary C(sp3)-Si Bond Formation via Reactivity Umpolung of Silyl Reagents [0.03%]
三级C(sp3)-Si键形成反应中的官能团活性颠倒以及有机硅试剂的应用
Yu-Qing Zheng,Wang Wang,Hong-Gui Huang et al.
Yu-Qing Zheng et al.
A transition-metal-free decyanative silylation of malononitriles with silyl chlorides enabled by a silyl umpolung strategy is described. This reaction involves NaOtBu-promoted silylboranes addition to malononitriles to generate electrophili...
Palladium-Catalyzed Directed C(sp3)-H Activation/Lactonization Cascade of 2-Acyl N-Heteroarenes with 2-Halobenzoic Acids: A Route to Substituted Isocoumarins [0.03%]
钯催化2-酰基N-杂芳烃与2-卤代苯甲酸的选择性C(sp3)-H酰化/内酯化串联反应：合成取代异香豆素的新方法
Mahesh Anil Sonawane,Dinesh G Thakur,Raj N Patel et al.
Mahesh Anil Sonawane et al.
A palladium-catalyzed, N-directed C(sp3)-H functionalization and intramolecular lactonization of 2-acyl N-heteroarenes with 2-halobenzoic acids is reported, providing an efficient synthetic route to access N-heteroarene-substituted isocouma...
Electroreductive Cross-Electrophile Coupling of Aldimine with Chlorosilanes Enabling the Synthesis of α-Aminosilanes [0.03%]
亚胺和氯硅烷的电化学交叉偶联反应合成α-氨基硅烷化合物
Yulin Peng,Sheng Li,Qian Su et al.
Yulin Peng et al.
α-Aminosilanes serve as synthetically valuable building blocks due to their potential as α-amino radicals/anion precursors. However, existing synthetic methods often suffer from limitations such as low functional group compatibility, the ...
Photoinduced Lactamization/Truce-Smiles Rearrangement Cascade Enables Access to Lactam-Fused β-Arylethylamines [0.03%]
光诱导的内酰胺化/Truce-Smiles重排级联反应实现含氮杂环化合物的高效构建
Panyi Huang,Yixuan Tang,Xinyu Li et al.
Panyi Huang et al.
The radical Truce-Smiles rearrangement (TSR) is a powerful and step-economical 1,4-aryl migration strategy that enables the direct synthesis of high-value β-arylethylamine pharmacophore from simple materials. Herein, we report the diastere...
Nickel-Catalyzed Hydrocyanoalkylation of Terminal Alkynes: A Route to Tetrasubstituted (Z)-Alkenyl Nitriles [0.03%]
镍催化末端炔烃的羟腈烷基化反应：制备四取代(Z)烯基腈的新方法
Jian Yang,Mei Zhang,Yin Ban et al.
Jian Yang et al.
Alkenyl nitriles represent an important structural motif in medicinal chemistry. However, efficient and general methods for the stereoselective synthesis of their tetrasubstituted (Z)-alkenyl nitriles remain a significant challenge. Herein,...
Visible-Light Photoredox Synthesis of Chroman-4-ones from Sulfoxonium Ylides [0.03%]
利用硫𬭩盐亚离子通过可见光光电氧化合成查尔酮-4-酮类化合物
Hyemin Ko,Ujjwal Karmakar,Miseon Park et al.
Hyemin Ko et al.
Organic chroman-4-ones are valuable structural motifs, yet many existing synthetic routes rely on harsh conditions or generate toxic byproducts. Here we report a mild and environmentally compatible visible-light method that employs sulfoxon...
Electrochemical Dearomative Reduction of Indole Derivatives Mediated by Ph3P(O) [0.03%]
磷𬭩盐介导的吲哚衍生物的电化学去芳构化还原反应
Ranran Zhu,Xiaoqi Guo,Yirui Shen et al.
Ranran Zhu et al.
Ph3P(O)-mediated electrochemical dearomative reduction of indole derivatives has been established, providing a straightforward and sustainable approach to hydrogenated and deuterated indolines. The protocol eliminates the need for an extern...
Dongke Zhang,Xinru Zhai,Yi Zhou et al.
Dongke Zhang et al.
Herein, we reported a one-pot synthesis of N-CF3 diarylamines using AgSCF3 and AgF. This work provides a robust protocol for the efficient trifluoromethylation modification of diarylamines, enabling the concise one-pot synthesis of diarylam...
Photocatalyzed Site-Selective Formal β-C(sp3)-H Sulfonylation of Ketones with Sulfinates [0.03%]
酮的选择性β-C(sp³)-H磺化反应合成光学纯α-手性磺酸酯和砜
Jun Xu,Jingyi Zhang,Zhixiong Wang et al.
Jun Xu et al.
Herein, we report a photocatalytic strategy for the site-selective formal β-C(sp3)-H sulfonylation of ketones. This method operates under mild conditions and exhibits broad functional group compatibility. Its utility is demonstrated throug...
Electrochemical Synthesis of 1,2-Substituted N-Amido Benzimidazoles by Reduction of Nitroarenes [0.03%]
纳米金属的电化学还原合成N-酰基苯并咪唑𬭩盐及其反应性研究
Daniel Doellerer,Aaron Schüll,Thomas Weyhermüller et al.
Daniel Doellerer et al.
Despite the vast number of reports on benzimidazoles, 1,2-substituted N-amido benzimidazoles remain an underrepresented and scarcely accessible compound class with promising pharmacological relevance. We present a safe, reliable electrochem...