Synthesis of Spiro[indoline-3,3'-pyridine]-2,2'-diones via an Annulo- and Diastereospecific [2 + 4] Annulation [0.03%]
通过环状[2+4]环加成高度对映和偶联立体选择性合成螺缩酮化合物Spiro[indoline-3,3'-pyridine]-2,2'-diones
Yuliang Wei,Qingchun Meng,Jiaxi Xu
Yuliang Wei
A tandem strategy has been designed and implemented for the efficient synthesis of spirooxindoles from 3-diazoquinoline-2,4-diones with α,β-unsaturated imines. The synthetic strategy involves the ring-contractive Wolff rearrangement of 3-...
Selective Synthesis of Fluorine Liquid Crystals with a Triphenyleno[2,3- b]benzofuran Core: Heterocyclic Annulation, Columnar Mesophase, and Fluorescence [0.03%]
选择性合成三苯基并苯并芴核氟代液晶：杂环化、柱状介晶相和荧光性质研究
Zi-Ling Ou,Meng-Xiang Hao,Bo Xiao et al.
Zi-Ling Ou et al.
Fluorinated discotic liquid crystals are highly promising organic semiconductor materials for electronic device research. Their exceptional self-assembly properties and thermal stability enable the formation of long-range, ordered columnar ...
Organocatalytic Asymmetric α-C-H Allylation of N-Arylidene-Protected Alkyl Amines [0.03%]
有机小分子催化N-芳甲酰胺亚胺亚甲基碳氢键的 allyl 反应及其立体选择性研究
Jun Liu,Yujie Dong,Sen Feng et al.
Jun Liu et al.
Chiral amines represent significant synthetic targets in organic chemistry, as their synthesis holds significant value in drug innovation. Despite asymmetric α-functionalization of amines having been well developed as a powerful strategy, ...
Rh-Catalyzed Desymmetric Hydroformylation of 1,3-Bis(methylene)cyclopentanes [0.03%]
铑催化1,3-双(甲基烯基)环戊烷的不对称氢.formulaeoferror反应
Ting Ren,Tianxiang Ren,Cai You et al.
Ting Ren et al.
A highly enantio- and diastereoselective rhodium-catalyzed desymmetric hydroformylation of 1,3-bis(methylene)cyclopentanes has been developed using (R,R)-DTBM-YanPhos (up to 99% yield, 99% ee, and 50:1 dr), enabling access to chiral aldehyd...
Discovery of seco-(9β-H)-Pimarane Diterpenoids from Icacina oliviformis with Synergistic Anti-Colorectal Cancer Activity [0.03%]
伊息迦树中分离得到的新型紫杉烷二萜及其抗结肠癌增效作用研究
Mingming Xu,Di Di,Mengting Wang et al.
Mingming Xu et al.
Phytochemical investigation of the leaves of Icacina oliviformis led to the isolation of nine previously undescribed seco-(9β-H)-pimarane diterpenoids (1-9), along with two biosynthetic precursors (10 and 11). Their structures were elucida...
Synthesis of N-(4-Vinylidenetetrahydrofuran-2-yl)amides and Applications in Skeletal Rearrangement to 2,3-Dihydro-1 H-pyrrol-2-ols/Substituted Pyrroles and Bridged Bicyclic Scaffold Construction [0.03%]
N-(4-亚乙烯四氢呋喃-2-基)酰胺的合成及其在骨架重排至2,3-二氢-1H-吡咯-2-醇/取代吡咯和稠环骨架构建中的应用
Chengyan Xie,Chenqi Liu,Dengke Ma
Chengyan Xie
Advancing molecular complexity enhances biological activity and material functions, accelerating drug discovery. Thus, the synthesis of complex structures from simple precursors is crucial. A Lewis acid-catalyzed method to prepare polyfunct...
Spectaterpenoids A-G, Sesterterpenoids with Unprecedented Polycyclic Ring System from Aspergillus spectabilis [0.03%]
来自秀丽枝顶孢霉的spectaterpenoids A-G：一种具有空前多环体系的倍半萜类化合物
Mengsha Wei,Yongqi Li,Guiying Xin et al.
Mengsha Wei et al.
Spectaterpenoids A-G (1-7), seven novel sesterterpenoids with five distinct skeleton types, along with one known analogue (8), were characterized from Aspergillus spectabilis. Notably, compound 1 was a nitrogenous sesterterpenoid possessing...
Computation-Enhanced Structure Elucidation of Cyclopropane-Containing Polyketides Ikeiamides A-M [0.03%]
计算辅助环丙烷并多肽类化学生物碱Ikeiamides A-M的结构鉴定
Asahi Tajima,Nao Tanaka,Ryo Yamanaka et al.
Asahi Tajima et al.
Ikeiamides A-M (1-13), cyclopropane-containing polyketides, were isolated from a marine Caldora sp. cyanobacterium. Although 1-13 are chemically unstable compounds and nine were obtained only in trace quantities (
Generation of Polysubstituted Tetrahydrofurans via Urea-Enabled, Pd-Catalyzed Olefin Heteroannulation [0.03%]
脲促进的钯催化 olefin 炔基环化反应合成多取代四氢呋喃类化合物
Shannon T O&#x;Neil,Owen E Monteferrante,Brooke R Stanley et al.
Shannon T O&#x;Neil et al.
Herein, we report a palladium-catalyzed heteroannulation approach to couple 2-bromoallyl alcohols and 1,3-dienes to generate a broad range of polysubstituted tetrahydrofuran (THF) rings enabled by urea ligands. Under urea-enabled Pd catalys...
Photoinduced Dearomative Oxyimination of Indoles Using Oxime Esters as Bifunctional Radical Precursors [0.03%]
肟酯作为双官能团自由基前体物质用于吲哚的光致去芳构化氧亚胺化反应中
Ming Yang,You Zi,Shun-Jun Ji et al.
Ming Yang et al.
A photoinduced, metal-free, and regioselective oxyimination of indole derivatives has been developed, enabling efficient difunctionalization via simultaneous C-O and C-N bond formation. Using oxime esters as dual radical precursors, this mi...