Talamangins A-C, Immunosuppressive and Anti-inflammatory Nitrogenated Azaphilone Hybrids from Talaromyces mangshanicus SB17 [0.03%]
来自霉草青霉SB17的具有免疫抑制和抗炎活性的含氮类菲立酮杂环化合物塔拉曼ジンA-C
Wan-Peng Li,Yi-Kai Sun,Chun-Lun Qin et al.
Wan-Peng Li et al.
Three unprecedented nitrogenated azaphilone hybrids, talamangins A-C (1-3), were isolated from the endophytic fungus Talaromyces mangshanicus SB17. Their structures, along with their absolute configurations, were determined by extensive spe...
Hexafluoroisopropanol-Mediated Hydroaminoalkylation-Aza-Prins for Construction of α-Amino-butenolide [0.03%]
六氟异丙醇促进的氢胺化-aza-Prins反应构建α-氨基丁内酯类化合物
Jianlian Huang,Zhongyi Zeng,Zhi Zhou et al.
Jianlian Huang et al.
The widespread presence of butenolide motifs in pharmaceuticals, natural products, and small-molecule biological probes has continuously motivated the development of efficient synthetic strategies. Herein, we describe a practical and broadl...
N, N'-Di-Boc- N″-fluorosulfonyl-guanidine: A SuFEx-Enabled Guanylating Reagent (SuFEx-G) with Enhanced Reactivity on Water [0.03%]
N,N'-二Boc-N"-氟磺酰基-瓜尔尼啶：一种通过SuFEx活化的瓜尔尼雷剂（SuFEx-G），并在水中表现出增强的反应性
Long Xu,Hanzheng Li,Meng-Meng Zheng et al.
Long Xu et al.
We report N,N'-di-Boc-N″-fluorosulfonyl-guanidine (SuFEx-G), a bench-stable SuFEx-enabled guanylating reagent with unprecedented "on-water" reactivity. In MeCN/H2O, it forms oil droplets with aromatic amines, hydrazines, and hydrazides, ac...
Igidamycins A-C, Rare Sugar-Bearing Anthracycline Glycosides from a Marine Actinomycete, Streptomyces sp [0.03%]
来自海分枝杆菌Streptomyces.sp.的稀有糖连接蒽环糖苷化合物игидамицин A-C
Jungro Lee,Yong-Joon Cho,Kyuho Moon et al.
Jungro Lee et al.
Genome-guided mining of marine Streptomyces sp. GCU-142 led to the identification of three unprecedented sugar-bearing anthracycline glycosides, igidamycins A-C (1-3). The structures of 1-3 were assigned by spectroscopic analysis including ...
Li Huang,Qili Jiang,Chunlan Song et al.
Li Huang et al.
O-Phosphorylation is a common way to make phosphates, but its reliance on the formation of an O-P bond restricts it to hydroxyl groups and lacks selectivity with other competing nucleophiles. Herein, we report a photoredox/copper-mediated m...
Asymmetric Saddle-Shaped Nanographenes Integrating Helicene and Heptagon Motifs: Synthesis and Chiroptical Properties [0.03%]
手性富勒烯螺烯集成的鞍形纳米石墨烯的对映选择合成及圆二色光谱研究
Jiawei Gao,Guofeng Chen,Chengxiu Wang et al.
Jiawei Gao et al.
Three curved heptagon-embedded nanographenes bearing a [5]/[6]helicene motif (5, 7, and 11) have been successfully synthesized through a Scholl-type oxidative cyclodehydrogenation. Single-crystal X-ray diffraction indicated that the introdu...
Selective Synthesis of 5-Nitroindoles through a Ag-Catalyzed Nitro Rearrangement/Cyclization Cascade of N-(o-Alkynylphenyl)nitramines [0.03%]
银催化N-(o-叠氮基苯基)硝胺的硝基重排/环化串联反应合成5-硝基吲哚类化合物
Itaru Nakamura,Shuto Matsuoka,Masahiro Terada
Itaru Nakamura
The reactions of N-(o-alkynylphenyl)nitramines in the presence of catalytic amounts of AgNTf2 afforded 5-nitroindoles in good to acceptable yields in a site-selective manner. This cascade reaction is initiated by selective migration of the ...
Yufei Zhang,Taoyu Weng,Jun Xu et al.
Yufei Zhang et al.
Spin-1/2 open-shell polycyclic aromatic hydrocarbons (PAHs) typically exhibit pronounced redox amphotericity; however, accessing species with high reduction potentials (>-0.5 V) remains challenging. Herein, we report the synthesis and cryst...
Modular Synthesis of (Z)-Allylsilanes via Copper-Catalyzed Cascade Silylation and Horner-Wadsworth-Emmons Reaction [0.03%]
铜催化串联硅芳基化和霍纳-沃斯华-艾姆斯反应构建(E)-亚烯基硅烷及(Z)-亚烯基硅烷
Eunhye Pi,Jongsung Lee,Jaesook Yun
Eunhye Pi
We report a copper-catalyzed cascade silylation/Horner-Wadsworth-Emmons (HWE) reaction for the stereoselective synthesis of (Z)-allylsilanes (up to 92% yield, Z/E > 20:1) through efficient three-component reactions of an unsaturated phospho...
Stereoselective Synthesis of Indoline-Fused Cyclobutanes via Dual Functionalization of Alkynyl Diazo Carboxylates [0.03%]
通过烷基叠氮羧酸酯的双重官能团化立体选择性合成并四苯融合吲哚啉
Priya Sharma,Akashdeep Sharma,Nishant Joon et al.
Priya Sharma et al.
We report stereoselective synthesis of indoline-fused cyclobutanes through dual functionalization of alkynyl diazoacetates. The development proceeds through Rh-catalyzed insertion of alkynyl carbenes into 2-alkenyl anilines, followed by a b...