Oncolytic Adenoviral Infection of Chordoma Achieves Treatment Efficacy Associated with Immunologic Response and Tumor Microenvironmental Alteration [0.03%]
溶瘤腺病毒治疗软骨肉瘤的疗效与免疫反应和肿瘤微环境改变相关
Xizi Wu,Daniel Ledbetter,Jen-Wei Tsai et al.
Xizi Wu et al.
Background: Chordoma is a midline neoplasm accounting for approximately 20% of primary spinal tumors. Due to chordoma's locally aggressive nature, patients experience high rates of disease progression and have limited tre...
Metabolomics and machine learning for early diagnosis of leptomeningeal metastasis: caution before clinical application [0.03%]
代谢组学和机器学习在早期诊断脑膜转移中的应用：临床应用前的谨慎态度
Ryan G Rilinger,Andrew Dhawan
Ryan G Rilinger
Spatial Transcriptomics Characterisation of Radionecrotic Changes in Glioblastoma Patients [0.03%]
放射诱导胶质母细胞瘤坏死改变的空间转录组学特征分析
Zaira Seferbekova,Michael Ritter,Gleb Ruckhovich et al.
Zaira Seferbekova et al.
Background: IDH-wildtype Glioblastoma (GB) is the most prevalent primary malignant CNS tumour in adults. The standard treatment regimen involves radiotherapy, which can cause radionecrotic (postactinic) changes as a late-...
DNA copy number patterns reveal prognostic markers and elucidate mechanisms of evolution in IDH-mutant astrocytoma [0.03%]
DNA拷贝数特征揭示了IDH突变型星形细胞瘤的预后标志物并阐明其演化机制
Kristen L Drucker,Arijit Panda,Paul A Decker et al.
Kristen L Drucker et al.
Background: Current literature suggests IDH-mutant astrocytoma contains several molecular subgroups. In this study we are interested in determining the connection between different molecular subgroups with grade and/or su...
Mishaal Munir,Matthew Hall,Minesh P Mehta
Mishaal Munir
TIGIT expression dictates the immunosuppressive reprogramming of myeloid cells in glioblastoma [0.03%]
TIGIT的表达决定了髓系细胞在胶质母细胞瘤中的免疫抑制重塑作用
Mohammad Asad,Julio Inocencio,Stefan Mitrasinovic et al.
Mohammad Asad et al.
Background: Immunotherapy has yet to make significant gains in glioblastoma (GBM) treatment, due in part to GBM-mediated immune suppression. Increasing evidence points to critical roles for tumor-derived extracellular ves...
Jennie W Taylor
Jennie W Taylor
Automated Delineation of Putative Non-Contrast-Enhancing Tumor in Glioblastoma: Prognostic Insights [0.03%]
自动界定胶质母细胞瘤中疑似非增强肿瘤的边界：预后洞察
Maria Gómez-Mahiques,Carles Lopez-Mateu,F Javier Gil-Terrón et al.
Maria Gómez-Mahiques et al.
Background: Precise delineation of non-contrast-enhancing tumor (nCET) in glioblastoma (GB) is critical for maximal safe resection, yet routine imaging cannot reliably separate infiltrative tumor from vasogenic edema. The...
NQO1-Mediated Oxidative Stress Resistance and Tumor Microenvironment Remodeling in Glioblastoma [0.03%]
胶质母细胞瘤中NQO1介导的氧化应激抵抗及肿瘤微环境重塑
Yangqing Li,Tao Kang,Zhen Jia et al.
Yangqing Li et al.
Background: Glioblastoma (GBM) is a highly aggressive brain tumor, with glioblastoma stem cells (GSCs) occupying the pinnacle of a complex tumor microenvironment (TME), conferring therapeutic resistance. The TME plays a r...