Randomized phase III study of high-dose methotrexate and whole-brain radiotherapy with/without temozolomide for newly diagnosed primary CNS lymphoma: JCOG1114C [0.03%]
高剂量甲氨蝶呤联合全脑放疗加上或不加替莫唑胺治疗原发中枢神经系统淋巴瘤的随机III期研究：JCOG1114C研究
Kazuhiko Mishima,Ryo Nishikawa,Yoshitaka Narita et al.
Kazuhiko Mishima et al.
Background: The goal was to determine whether the addition of temozolomide (TMZ) to the standard treatment of high-dose methotrexate (HD-MTX) and whole-brain radiotherapy (WBRT) for primary central nervous system lymphoma...
Clinical Trial
Neuro-oncology. 2023 Apr 6;25(4):687-698. DOI:10.1093/neuonc/noac246 2023
ARL13B promotes angiogenesis and glioma growth by activating VEGFA-VEGFR2 signaling [0.03%]
ARL13B通过激活VEGFA-VEGFR2信号促进血管生成和胶质瘤生长
Limin Chen,Xinsheng Xie,Tiantian Wang et al.
Limin Chen et al.
Background: Tumor angiogenesis is essential for solid tumor progression, invasion and metastasis. The aim of this study was to identify potential signaling pathways involved in tumor angiogenesis. ...
Safety and patterns of survivorship in recurrent GBM following resection and surgically targeted radiation therapy: Results from a prospective trial [0.03%]
术后复发胶质母细胞瘤再次切除并手术导向放射治疗后的生存模式及安全性：一项前瞻性试验的结果分析
Kris Smith,Peter Nakaji,Theresa Thomas et al.
Kris Smith et al.
Background: Treatment of recurrent glioblastoma (GBM) remains problematic with survival after additional therapy typically less than 12 months. We prospectively evaluated whether outcomes might be improved with resection ...
Clinical Trial
Neuro-oncology. 2022 Nov 2;24(Suppl 6):S4-S15. DOI:10.1093/neuonc/noac133 2022
Turning on the light for brain tumor surgery: A 5-aminolevulinic acid story [0.03%]
开启肿瘤手术的那束光——5-氨基乙酰丙酸的故事
David J McCracken,Alexander J Schupper,Nikita Lakomkin et al.
David J McCracken et al.
To aid surgeons in more complete and safe resection of brain tumors, adjuvant technologies have been developed to improve visualization of target tissue. Fluorescence-guided surgery relies on the use of fluorophores and specific light wavel...
Surgically targeted radiation therapy (STaRT) trials for brain neoplasms: A comprehensive review [0.03%]
脑肿瘤的手术靶区放疗(STaRT)临床试验：系统综述
Yazmin Odia,Alonso N Gutierrez,Rupesh Kotecha
Yazmin Odia
The mainstays of radiation therapy include external beam radiation therapy (EBRT) and internally implanted radiation, or brachytherapy (BT), all with distinct benefits and risks in terms of local or distant tumor control and normal brain to...
Alexander J Schupper,Tori Chanenchuk,Anna Racanelli et al.
Alexander J Schupper et al.
Magnetic resonance imaging-guided laser interstitial thermal therapy (LITT) is an ablative procedure using heat from a laser to provide cytoreduction in tissue. It is a minimally invasive procedure that has been used in intracranial patholo...
Updates in intraoperative strategies for enhancing intra-axial brain tumor control [0.03%]
术中策略更新：提高颅内肿瘤控制力
Adela Wu,Janet Yuling Wu,Michael Lim
Adela Wu
To ensure excellent postoperative clinical outcomes while preserving critical neurologic function, neurosurgeons who manage patients with intra-axial brain tumors can use intraoperative technologies and tools to achieve maximal safe resecti...
Spinal brachytherapy [0.03%]
脊髓近距离放射治疗
Gordon Mao,Nicholas Theodore
Gordon Mao
Brachytherapy remains an underrecognized and underutilized radiation therapy modality for the treatment of spinal tumors. This article summarizes the existing body of medical literature on the usage, indications, techniques, and outcomes of...
Novel intraoperative strategies for enhancing tumor control: Future directions [0.03%]
新型术中策略以增强肿瘤控制：未来方向
Alexander F Haddad,Manish K Aghi,Nicholas Butowski
Alexander F Haddad
Maximal safe surgical resection plays a key role in the care of patients with gliomas. A range of technologies have been developed to aid surgeons in distinguishing tumor from normal tissue, with the goal of increasing tumor resection and l...
Radiation's formulations [0.03%]
辐射的公式化研究
C Leland Rogers
C Leland Rogers