Hyperactive BMP and Mechanosignaling Remodel Chromatin to Drive Aberrant Osteogenesis in FOP [0.03%]
FOP中活化的BMP和机械信号重塑染色质以驱动异常骨形成
Ellen Y Zhang,Douglas W Roberts,Sang Hyun Lee et al.
Ellen Y Zhang et al.
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder in which a recurrent ACVR1 (R206H) mutation drives progressive heterotopic ossification (HO). Although hypersensitive BMP signaling is well established, the mechanisms b...
Impaired vitamin D signaling reveals novel targets in tooth and alveolar bone [0.03%]
维生素D信号通路受损揭示了牙齿和牙槽骨的新目标
Alexandra Jimenez-Armijo,Naji Kharouf,Supawich Morkmued et al.
Alexandra Jimenez-Armijo et al.
Teeth are established as targets for vitamin D metabolites but have retained less attention than the well-defined bone cell metabolism. Here we report that VDRgem mice, which bear a point-mutated vitamin D receptor (VDR) unresponsive to the...
Central tibia marrow density is associated with incident fractures among postmenopausal females [0.03%]
中央胫骨髓密度与绝经后女性骨折的相关性研究
Irshad Ahmed,Costa Sarah,Yan Ryan et al.
Irshad Ahmed et al.
Objective: to examine regional tibial marrow density as measured by peripheral quantitative computed tomography (pQCT) and determine its association with incident fragility fractures among postmenopausal females. ...
The Journal of Bone and Mineral Research (JBMR) 40th anniversary celebration: the fourth decade (part 1) [0.03%]
骨矿研究杂志(JBMR)四十周年庆典：第四十年（第一部分）
Roberto Civitelli
Roberto Civitelli
Injectable Matrix Metalloproteinase-Responsive Nanoparticle Hydrogel Scaffold for Sustained Local Drug Delivery in Fibrous Dysplasia [0.03%]
用于纤维性骨异常的长效局部药物递送的可注射基质金属蛋白酶响应型纳米颗粒水凝胶支架
Lu Xing,Zhongyu Liu,Kaichao Wang et al.
Lu Xing et al.
Receptor activator of nuclear factor kappa-B ligand (RANKL) inhibition has shown significant therapeutic benefit in fibrous dysplasia. However, sustained RANKL inhibition is required to maintain its therapeutic effect. Moreover, disease reb...
Ryan D Ross,Michael T Yin
Ryan D Ross
Vertebral fractures in a young woman: the impact of hypogonadism, glucocorticoids and chronic disease [0.03%]
年轻女性椎骨骨折：低性腺素、糖皮质激素和慢性疾病的影响
Madhuni Herath,Hanh H Nguyen,Frances Milat et al.
Madhuni Herath et al.
A premenopausal woman was reviewed for painful vertebral fractures in the context of prednisolone exposure for her newly diagnosed systemic lupus erythematosus. Known clinical risk factors for bone loss included exposure to depot medroxypro...
Circadian disruption accelerates the progression of experimental periodontitis via PER2/miR-21-mediated inflammatory and osteogenic dysregulation [0.03%]
生物钟紊乱通过PER2/miR-21介导的炎症和成骨调节失常加速实验性牙周炎的发展
Shiyu Li,Jingxian Zhu,Nianke Liu et al.
Shiyu Li et al.
Periodontitis is a chronic inflammatory disease characterized by progressive alveolar bone destruction and represents a major cause of tooth loss. It has also been associated with systemic inflammatory conditions such as diabetes. Circadian...
Histone methyltransferase NSD1 maintains Egr1 expression to orchestrate primary/reactionary dentinogenesis [0.03%]
组蛋白甲基转移酶NSD1通过维持Egr1表达调控原发性/继发性牙本质生成
Xufei Guo,Lingyun Yan,Jiaxin Niu et al.
Xufei Guo et al.
Dentinogenesis is a highly coordinated process orchestrated by odontoblasts that is not only critical for tooth development, but also essential for pulp vitality after injury. Although the signaling pathways regulating this process have bee...
Automated abdominal aortic calcification, muscle health and incident falls: the UK Biobank Imaging Study [0.03%]
英国生物样本库影像学研究中自动腹部主动脉钙化、肌肉健康和跌倒的关系
Abadi K Gebre,Cassandra Smith,James Webster et al.
Abadi K Gebre et al.
Emerging evidence suggests that vascular disease is linked with poorer muscle strength and higher falls risk. We evaluated the association between abdominal aortic calcification (AAC), scored using a well-established and validated 24-point ...