Willem Lems,Joop van den Bergh,Caroline Wyers
Willem Lems
MULTIDIMENSIONAL SPATIAL MAPPING OF EXTRACELLULAR MATRIX: CARTILAGINOUS-OSSEOUS COMPOSITE FORMATION, TENDON INTEGRATION AND VASCULARIZATION DURING SKELETAL GROWTH AND REPAIR [0.03%]
软骨-骨复合体形成、肌腱整合和血管化在骨骼生长与修复过程中的多维空间图谱
Julia Etich,Kristina Probst,Jan Miller et al.
Julia Etich et al.
The extracellular matrix provides a crucial tissue-specific signaling hub and structural scaffold that transduces biomechanical force load into cellular responses. While this is especially important in the musculoskeletal joint, the spatial...
Race-Neutral FRAX without BMD outperforms FRAX without BMD in a multiethnic cohort with Diabetes or Hypertension [0.03%]
无种族对照的FRAX（不包括BMD）在糖尿病或高血压多民族队列中的表现优于FRAX（不包括BMD）
Rajesh K Jain,Eric Polley,Tamara Vokes
Rajesh K Jain
FRAX is poorly validated in Black and Hispanic people in the United States. We recently demonstrated that FRAX underestimated fractures in Black and Hispanic patients with diabetes (DM), but it is not known if this is a diabetes-specific is...
Women's Musculoskeletal Health: Insights from the 2024 National Academies of Sciences, Engineering, and Medicine Report on Chronic Conditions [0.03%]
女性骨关节健康：2024年国家科学院、工程院和医学院关于慢性疾病报告的见解
M Matthews,R Cooper,S L Dallas et al.
M Matthews et al.
In 2024, the National Academies of Sciences, Engineering, and Medicine (NASEM) published a report entitled Advancing Research on Chronic Conditions in Women. A major purpose of this report was to summarize the current state of research into...
Complement factor H (CFH), an immune factor enhances osteoblast differentiation and correlates with bone density [0.03%]
补体因子H通过增强成骨细胞分化促进骨骼生成并影响骨密度
Li Chen,Huimin Hu,Weimin Qiu et al.
Li Chen et al.
Complement factor H (CFH) is an immune regulator that inhibits the complement system. Here, we identify CFH as a secreted and regulated factor in human bone marrow skeletal stem cells (hBMSCs) culture during osteoblast (OB) differentiation....
Central Giant Cell Granuloma: A Decade of Institutional Experience and Curative Potential of Neoadjuvant Denosumab [0.03%]
中央巨细胞颗粒病的十年诊治经验及地诺单抗新辅助治疗的潜在治愈效果
Chih Ying Ko,Hedley Coleman,James Kim et al.
Chih Ying Ko et al.
Central giant cell granuloma (CGCG) is a rare lesion of the maxilla and/or mandible affecting young adults. Traditionally, first-line management includes surgery, however surgery portends significant associated risks, including risk of disf...
Bone and Radiologic Findings in Congenital Generalized Lipodystrophy: A Systematic Review and Report of 60 Cases [0.03%]
先天性全身性脂代谢不良的骨骼及影像学特征：系统回顾及60例报告
M Mahlon Dyer,Rebecca M Tuska,Maiah N Brush et al.
M Mahlon Dyer et al.
Congenital Generalized Lipodystrophy (CGL), usually caused by pathogenic variants in AGPAT2 (CGL1) and BSCL2 (CGL2), is characterized by near-total loss of subcutaneous adipose tissue, low leptin levels and severe metabolic and systemic com...
Integrating chromatin accessibility and GWAS identifies RUNX3 and TRAF1 as susceptibility genes for rheumatoid arthritis [0.03%]
整合染色体可接近性和GWAS识别RUNX3和TRAF1作为类风湿关节炎的易感基因
Nai-Ning Wang,Dong-Li Zhu,Feng Jiang et al.
Nai-Ning Wang et al.
Genome-wide association studies (GWAS) have identified numerous rheumatoid arthritis (RA) associated genetic variants, most of which localize to non-coding regulatory regions (eg, enhancers), but their functional annotation remains a barrie...
ARHGEF3 Deletion Increase Bone Formation and Suppresses Bone Resorption in Adult Mice [0.03%]
ARHGEF3缺失可增加小鼠成骨并抑制破骨形成
Amit Chougule,Chunbin Zhang,Jordan Denbow et al.
Amit Chougule et al.
ARHGEF3 (also known as XPLN) is a Rho guanine nucleotide exchange factor that activates RhoA/B. Variants in the ARHGEF3 gene are associated with hip and spine BMD and fracture risk, suggesting ARHGEF3 may play key role in maintaining bone m...
Samuel J Stephen,Joy Y Wu,Christopher J Hernandez
Samuel J Stephen
Mechanical failure of bone - not bone density - is the primary clinical concern for skeletal disorders and diseases. Bone mass and density are major contributors to whole bone strength, which is why therapeutics that regulate bone volume by...