Age and sex specific incidence rates and future projections for hip fractures in the Gambia, West Africa, and comparison across four countries in Africa [0.03%]
冈比亚髋关节骨折的年龄和性别特异性发病率及未来预测及其与非洲另外三国的比较
Hannah Wilson,Kebba Marenah,Anya Burton et al.
Hannah Wilson et al.
Longevity in African populations is increasing, where deprivation and malnutrition are common; hence fragility fracture incidence is expected to increase. Healthcare systems must adapt to provide for this aging population; however, currentl...
CARD14-Mediated MYC Interaction Promotes Osteoclastogenesis and Bone Density Reduction in Adolescent Idiopathic Scoliosis [0.03%]
CARD14介导的MYC相互作用促进青少年特发性侧凸患者的破骨细胞生成及骨密度降低
Hao Luo,Sijian Lin,Jiachao Xiong et al.
Hao Luo et al.
Adolescent idiopathic scoliosis (AIS) is characterized by decreased bone mineral density (BMD), which is associated with an increased risk of skeletal fragility and poor long-term outcomes. This study explores the role of the CARD14 gene in...
Targeting FGFR3 gain-of-function with Infigratinib, a promising precision therapy for Hypochondroplasia [0.03%]
针对长肢端肥大症治疗的成纤维细胞生长因子受体3增效功能的抑制剂Infigratinib精准疗法研究
Antonella Forlino
Antonella Forlino
Fractures are Highly Correlated with Bone Density and Inversely Correlated with Bone Turnover Markers in Autosomal Dominant Osteopetrosis [0.03%]
常染色体显性遗传性 osteopetrosis 患者骨折与骨密度密切相关而与骨转换标志物呈负相关关系
Michael J Econs,Stuart J Warden,Ziyue Liu et al.
Michael J Econs et al.
Autosomal Dominant Osteopetrosis (ADO) is a rare, osteosclerotic disorder usually caused by missense variants in the CLCN7 gene, resulting in impaired osteoclastic bone resorption. Penetrance is incomplete and disease severity varies widely...
Use of DXA-derived 3D-modeling, as implemented by 3D-shaper®, for the assessment of fracture risk in a population-based setting [0.03%]
基于人群的骨折风险评估中使用DXA衍生的3D建模（由3D塑形者实施）
K Huininga,F Koromani,M C Zillikens et al.
K Huininga et al.
Introduction: 3D-modeling of hip DXA scans has been proposed to partition BMD into cortical surface (csBMD) and trabecular "volumetric" (tvBMD). We assessed in a population-based cohort whether such partitioning contribut...
Artificial gravity protects bone and prevents bone marrow adipose tissue accumulation in humans during 60 days of bed rest [0.03%]
人工重力保护人类骨骼并防止卧床60天期间骨髓内脂肪组织蓄积
K Culliton,G Melkus,A Sheikh et al.
K Culliton et al.
Inactivity has been associated with increased bone marrow adipose tissue (BMAT) and bone loss. Artificial gravity (AG) may prevent these complications. This randomized controlled trial investigated the effectiveness of AG at 2g at the feet ...
Letter in response to "atypical fractures at non-classical sites associated with anti-resorptive therapy: a systematic review" [0.03%]
关于“抗吸收疗法导致非典型部位非经典骨折的系统性回顾”的来信答复
Lucy E Collins,Alec Ronan,Evelyn Hutcheon et al.
Lucy E Collins et al.
Anne-Laure Bonnet,Lizaveta Aboishava,Michael Mannstadt
Anne-Laure Bonnet
Parathyroid hormone (PTH), produced by the parathyroid glands, plays a critical role in the regulation of calcium and phosphate homeostasis, acting primarily on bone and kidney to maintain serum calcium levels within a narrow range. PTH als...
Non-physiological direction loading increases bone adaptive responses by enhancing lacunocanalicular fluid dynamics [0.03%]
非生理学定向载荷通过增强骨小腔流体动力学增加骨适应性反应
Yuan Wang,Ruisen Fu,Haisheng Yang
Yuan Wang
It's been proposed that bone adaptation is "error-driven", namely, bone is more sensitive to non-physiological loading (e.g., loading in a non-physiological direction). However, the effect of physiological vs. non-physiological loading on b...
Atypical fractures at non-classical sites associated with anti-resorptive therapy: a systematic review [0.03%]
与抗吸收治疗相关的非典型不常见部位骨折：系统性综述
Maria P Yavropoulou,Socrates E Papapoulos
Maria P Yavropoulou