Effects of weight-loss interventions on bone health in people living with obesity [0.03%]
减肥干预措施对肥胖人群骨骼健康的影响
Julien Paccou,Claudia Gagnon,Elaine W Yu et al.
Julien Paccou et al.
Strategies to reduce weight in people living with obesity (PwO) include calorie restriction, metabolic and bariatric surgery (MBS), and anti-obesity drugs including glucagon-like peptide-1 receptor agonists (GLP-1Ra), such as liraglutide an...
A novel brachydactyly type E syndrome caused by variants in helix 8 of the PTH1R [0.03%]
由PTH1R第8螺旋区变异引起的新型并指（趾）症E综合征
Gavin Monahan,Jakob Höppner,Harald Jüppner et al.
Gavin Monahan et al.
The parathyroid hormone receptor 1 (PTH1R) transmits stimuli provided by parathyroid hormone (PTH) and PTH-related protein (PTHrP) and thus plays key roles in calcium and phosphate homeostasis as well as skeletal development. Variants in PT...
Denosumab and vascular calcification progression: smoke, but not yet fire [0.03%]
denosumab与血管钙化进程：疑云密布，但尚无定论
Ditte Hansen,Pieter Evenepoel
Ditte Hansen
Associations between body composition and bone loss in early postmenopausal women [0.03%]
早发性绝经妇女身体成分与骨量丢失之间的关系
Marina Vilar Geraldi,Giulia Gregori,Lisa Johansson et al.
Marina Vilar Geraldi et al.
The early postmenopausal period is characterized by rapid bone loss, accompanied by a decline in lean mass and an increase in fat mass, highlighting the importance of understanding how these changes influence bone health. This study aimed t...
Rural-urban differences in osteoporosis and sarcopenia prevalence among Gambian older adults: A pilot study [0.03%]
冈比亚老年人群中骨质疏松症和肌少症的城乡差异：一项初步研究
Mícheál Ó Breasail,Ayse Zengin,Camille Pearse et al.
Mícheál Ó Breasail et al.
Rural-urban bone mineral density (BMD) differences are well-described in high-income countries, typically with higher BMD in rural areas. However, despite rapid urbanization and longevity across Africa, such data remains scarce. This study ...
Acute effect of impact and resistance exercise on Wnt signaling modulators, bone and cartilage metabolism [0.03%]
冲击力和阻力运动对Wnt信号调节物、骨代谢和软骨代谢的急性影响
Benjamin Boxer,Zhuoyue Zhang,Jonathan P Folland et al.
Benjamin Boxer et al.
Impact and resistance exercise have potent osteogenic effects and may positively affect cartilage through tissue deformation. These effects may be mediated through inhibitors of Wnt signaling such as sclerostin and Dickkopf WNT signaling pa...
Systemic bone loss during fracture healing: new evidence from HR-pQCT analyses [0.03%]
骨折愈合期间骨量的丢失：HR-pQCT分析的新证据
Bettina M Willie,Seyedmahdi Hosseinitabatabaei
Bettina M Willie
Aromatase in adipose tissue exerts an osteoprotective function in male mice via phosphate regulation [0.03%]
脂肪组织中芳香化酶通过磷酸盐调节在小鼠骨保护中的作用
Aoi Ikedo,Michiko Yamashita,Maiko Hoshino et al.
Aoi Ikedo et al.
Aromatase contributes to maintenance of bone mass because male patients with loss-of-function mutations of CYP19A1 exhibit bone loss. Treatment with aromatase inhibitor also causes bone loss in men and post-menopausal women, suggesting that...
Imprinting and skeletal disorders: Lessons from Pseudohypoparathyroidism and Related Disorders [0.03%]
印记与骨骼异常：假性低甲状旁腺功能症及其相关疾病的经验教训
Yorihiro Iwasaki,Murat Bastepe
Yorihiro Iwasaki
Pseudohypoparathyroidism (PHP) was first described as a syndrome characterized by parathyroid hormone (PTH) resistance combined with skeletal abnormalities known as Albright's hereditary osteodystrophy (AHO). Studies have since focused on g...