Postnatal deletion of Dlx5/6 in Osx-lineage cells drives bone hypertrophy by regulating osteoblast expansion and maturation [0.03%]
Dlx5/6产后在Osx谱系细胞中缺失通过调节成骨细胞的增殖和成熟促进骨肥大
Morgane Bourmaud,Nicolas Narboux-Neme,Mylène Zarka et al.
Morgane Bourmaud et al.
Distal-less homeobox genes Dlx5 and Dlx6 are key regulators of osteoblast differentiation during skeletal development, but their role in postnatal bone remodeling remains poorly understood. To investigate this, we conditionally deleted Dlx5...
HR-pQCT measures of bone in autosomal dominant osteopetrosis highly correlate with fractures and inversely correlate with bone resorption markers [0.03%]
常染色体显性遗传性大理石骨病患者HR-pQCT骨检测指标与骨折密切相关并可反映骨吸收标志物的降低水平
Stuart J Warden,Erik A Imel,Ziyue Liu et al.
Stuart J Warden et al.
Autosomal dominant osteopetrosis (ADO) is a rare bone disorder caused by impaired osteoclastic resorption. Despite high bone mass, ADO is paradoxically associated with increased fracture risk. High-resolution peripheral quantitative compute...
Bone phenotype in a mouse model of Classical Ehlers Danlos syndrome with Col5a1 haploinsufficiency [0.03%]
Col5a1半定量不足的小鼠模型中经典型埃勒斯-丹洛斯综合征的骨表型
Keren Machol,Catherine G Ambrose,Deidre N Meyers et al.
Keren Machol et al.
Type V collagen is a key regulator in the formation of type I collagen fibrils in connective tissues including skin, tendons, and bones. Abnormalities in type V collagen cause classical Ehlers Danlos syndrome (EDS), a connective tissue diso...
Programmed cell death ligand 1 (PD-L1) inhibition in tumor naïve mice is bone-sparing throughout the lifespan [0.03%]
程序性死亡配体1(PD-L1)抑制在无肿瘤小鼠中终生具有保护骨量的作用
Madeline B Searcy,Gwenyth J Joseph,Jeremy F Kane et al.
Madeline B Searcy et al.
Immune checkpoint inhibitors (ICIs) which target immune checkpoint proteins like programmed cell death protein 1 (PD-1) and programmed cell death ligand 1 (PD-L1) have revolutionized cancer therapy. Skeletal toxicities are emerging immune-r...
Abnormal position of a GNAS methylation regulatory element causes autosomal dominant pseudohypoparathyroidism type 1B (PHP1B) [0.03%]
GNAS甲基化调节元件的异常位置导致常染色体显性假性甲状旁腺功能减退症1B型(PHP1B)
Andreea Apetrei,Nicolas Richard,Yorihiro Iwasaki et al.
Andreea Apetrei et al.
The parental imprinted GNAS complex locus encodes the α-subunit of the stimulatory G protein. Pseudohypoparathyroidism type Ib (PHP1B) is characterized by renal resistance to parathormone and is caused by epigenetic anomalies, ie, at least...
Ossification of the Posterior Longitudinal Ligament - Novel findings from Pandora's box of ENPP1 Deficiency [0.03%]
ENPP1缺乏症的未解之谜：PLL ossification的新发现
Lothar Seefried
Lothar Seefried
The Journal of Bone and Mineral Research (JBMR) 40th anniversary celebration: the fourth decade (Part 2) [0.03%]
骨矿研究杂志(JBMR)四十周年庆典：第四十年（第二部分）
Rajesh V Thakker
Rajesh V Thakker
Increased Prevalence of Coronary Artery Calcification in Patients with Post-Surgical Hypoparathyroidism [0.03%]
术后继发性低甲状旁腺素血症患者的冠状动脉钙化患病率增加
Sarah Thornhøj,Line Underbjerg,Lene Ring Madsen et al.
Sarah Thornhøj et al.
Hypoparathyroidism is a rare disease characterized by hypocalcemia and deficient parathyroid hormone secretion. Cohort studies suggest a higher risk of cardiovascular disease. However, imaging-based assessment of coronary artery disease is ...
Alendronate for 6 or 12 months following denosumab discontinuation in women with postmenopausal osteoporosis: A prospective observational study [0.03%]
利塞膦酸钠用于接受地诺单抗治疗后停药的绝经后骨质疏松症女性患者：一项前瞻性观察研究
Polyzois Makras,Athanasios D Anastasilakis,Andrea Palermo et al.
Polyzois Makras et al.
Unopposed denosumab (Dmab) discontinuation is followed by overshoot in bone turnover markers (BTM), rapid bone mineral density (BMD) loss, and elevated risk of multiple vertebral fractures. To preserve BMD gains and mitigate fracture risk i...