Christoph Beyersdorf,Uwe Maus,Felix Wiedmann et al.
Christoph Beyersdorf et al.
Osteoporosis is the most prevalent metabolic bone disease globally, characterized by decreased bone mass and microarchitectural deterioration, leading to an increased risk of fractures. While its pathogenesis is multifactorial, including ho...
Automated abdominal aortic calcification and trabecular bone score independently predict incident fracture during routine osteoporosis screening [0.03%]
基于腹部主动脉钙化和骨小梁分数的骨折预测模型用于常规骨质疏松筛查中的骨折风险预测
Abadi K Gebre,Marc Sim,Syed Zulqarnain Gilani et al.
Abadi K Gebre et al.
Abdominal aortic calcification (AAC), a marker of subclinical cardiovascular disease, has previously shown to be associated with low bone mineral density (BMD) and fracture. However, it remains unclear whether AAC is associated with trabecu...
Hypophosphatasia - Pathophysiological understanding, preclinical data looking beyond the skeleton, and upcoming treatments [0.03%]
低磷酸酶症：病理生理学理解、临床前数据和即将出现的治疗方式展望
Jose Luis Millán
Jose Luis Millán
Hypophosphatasia (HPP) is the genetic disorder caused by loss-of-function mutations in the ALPL gene that encodes tissue-nonspecific alkaline phosphatase (TNAP), an enzyme essential for physiological skeletal/dental mineralization. In HPP, ...
New Lens On Congenital Mild Bone Fragility: a Novel Col1a1 Knockout Mouse Model for Osteogenesis Imperfecta Type 1 [0.03%]
探究轻型先天性骨脆性的新模型：构建Ⅰ型成骨不全症的新Col1a1敲除小鼠模型
Lidiia Zhytnik,Laura Ventura,Anastasia Sclocco et al.
Lidiia Zhytnik et al.
Osteogenesis imperfecta (OI) is a genetic disorder characterized by bone fragility. It is one of the most prevalent rare skeletal dysplasias. The mildest form, OI type 1, predominantly results from collagen type I haploinsufficiency due to ...
Neural crest-specific disruption of Evc2 provides an animal model to study the temporomandibular joint (TMJ) development and homeostasis in response to jaw loading [0.03%]
特异性破坏神经嵴EVC2的小鼠模型在研究下颌骨负载应答的颞下颌关节(TMJ)发育及稳态中的应用
Rafael Correia Cavalcante,Honghao Zhang,Felicia Miranda et al.
Rafael Correia Cavalcante et al.
The temporomandibular joint (TMJ), essential for jaw movements, is susceptible to osteoarthritis (TMJ-OA), impacting a significant portion of the population. This study introduces an innovative genetic mouse model to explore TMJ development...
ENPP1 inhibition as a therapeutic approach for later-onset hypophosphatasia [0.03%]
以ENPP1为靶点治疗晚发型低磷酸酶症
Sonoko Narisawa,Flavia Amadeu de Oliveira,Cintia Kazuko Tokuhara et al.
Sonoko Narisawa et al.
Hypophosphatasia (HPP) is caused by loss-of-function mutations in the human ALPL gene that encodes tissue-nonspecific alkaline phosphatase (TNAP), whose deficiency results in the accumulation of the calcification inhibitor inorganic pyropho...
Improved Prediction of Hip Fracture Using Multi-Faceted Biomechanical Computed Tomography [0.03%]
基于多维度生物力学的CT图像可改善骨折预测性能
Tony M Keaveny,Annette L Adams,Eric S Orwoll et al.
Tony M Keaveny et al.
With the goal of preventing more hip fractures, a next generation of the VirtuOst® Biomechanical Computed Tomography (BCT) test was developed that integrates measurements from a clinical CT scan related to fall risk, impact force, and femo...
Bone microstructural and strength changes over one year in children with osteogenesis imperfecta are comparable to age- and sex-matched healthy controls [0.03%]
与年龄和性别相匹配的健康儿童相比，骨小结构和强度变化在一年内患有成骨不全症的儿童中相当
Seyedmahdi Hosseinitabatabaei,Samantha McCluskey,Carolyn Denton et al.
Seyedmahdi Hosseinitabatabaei et al.
Osteogenesis imperfecta (OI) is characterized by bone fragility with frequent fractures, especially in children. Some studies have used peripheral-quantitative computed tomography (pQCT) to examine bone density in children with OI and one c...
Biochemical phenotype of hypophosphatasia in asymptomatic individuals carrying ALPL variants [0.03%]
无症状携带者中低磷血症的生化特征
Rodrigo Montero-Lopez,Mariam R Farman,Florian Högler et al.
Rodrigo Montero-Lopez et al.
Hypophosphatasia (HPP) is the rare metabolic disorder caused by variants in the ALPL gene, resulting in deficient activity of tissue-nonspecific alkaline phosphatase (ALP). This leads to accumulation of substrates contributing to impaired b...