Trajectories of Areal Bone Mineral Density Significantly Differ by Patterning of Femoral Neck Area and Bone Mineral Content Across the Menopausal Transition [0.03%]
股骨颈面积和骨矿物质含量模式决定绝经期股骨皮质骨密度变化轨迹
Aleda M Leis,Karl J Jepsen,Erin Bigelow et al.
Aleda M Leis et al.
Clinical use of areal bone mineral density (aBMD) to identify fracture risk assumes that aBMD reflects bone mineral content (BMC). Yet, aBMD is calculated using a ratio of BMC and bone area, thus declines in aBMD may reflect a decline in BM...
Randomized controlled trial of an oral Gastrin Receptor Antagonist for the treatment of postmenopausal osteoporosis [0.03%]
胃泌素受体拮抗剂治疗绝经后骨质疏松症的随机对照试验
Marian Schini,Fatma Gossiel,Margaret A Paggiosi et al.
Marian Schini et al.
High gastrin levels may help explain the association between several conditions and osteoporosis, such as pernicious anaemia, the use of proton pump inhibitors, and atrophic gastritis. This study aimed to determine whether administering a g...
Considerations Regarding the Use of Romosozumab in a Patient at High Risk for Cardiovascular Disease [0.03%]
关于心血管疾病高风险患者使用 romosozumab 的考虑因素
Michael R McClung
Michael R McClung
Treatment decisions are being made for a 74 year-old woman with multiple and recent vertebral fractures. Romosozumab therapy is considered because of superior efficacy compared to other osteoporosis therapies. However, because of her age, w...
An enhanced fracture risk evaluation model (FREM) using national health data on morbidity and medications [0.03%]
基于全国健康数据的骨折风险评估模型（FREM）的改进
Sören Möller,Marlene Rietz,Frederik Lykke Petersen et al.
Sören Möller et al.
Osteoporosis is a major health concern in older individuals. Efficient case-finding is essential for timely risk assessment and treatment for high-risk patients. To prevent fractures and reduce the risk of subsequent disability, approaches ...
The relationship between fall risk, trochanteric soft tissue thickness, and hip fracture risk in older adults [0.03%]
老年人股骨颈软组织厚度、跌倒风险与髋部骨折之间的关系
Fjola Johannesdottir,Thor Aspelund,Sarah Mahar et al.
Fjola Johannesdottir et al.
Current fracture risk assessment does not directly include fall probability, despite most hip fractures resulting from falls. Additionally, the role of trochanteric soft tissue thickness (TST) in hip fracture risk remains unclear. This stud...
Solving Chewy Problems and a Pain in the Jaw: A Novel Mouse Model for Jaw Joint Malfunction [0.03%]
棘手问题和疼痛的下颌：下颌关节功能紊乱的小鼠模型的新研究
Andre J van Wijnen,Yasaman Daneshian
Andre J van Wijnen
Impaired organic and mineral extracellular matrix composition in early-onset osteoporosis [0.03%]
早发性骨质疏松症的细胞外基质成分异常
Agnes Ostertag,Bastien Léger,Eugenie Koumakis et al.
Agnes Ostertag et al.
Background: Early-onset osteoporosis (EOOP) is a rare form of primary osteoporosis defined by major skeletal fractures or low bone mineral density (BMD) that occurs in early age. However, the characteristics of the extrac...
Uncovering Racial and Genetic Disparities in FRAX Performance for Fracture Risk Assessment in Postmenopausal Women [0.03%]
揭示骨折风险评估工具FRAX在绝经后妇女中的种族和遗传差异性
Qing Wu,Jongyun Jung
Qing Wu
The Fracture Risk Assessment Tool (FRAX) is widely used in osteoporosis management, yet its performance across diverse racial, ethnic, and genetic populations remains uncertain. We evaluated the accuracy of FRAX in predicting fracture risk,...
Xiaoqiao Xu,Lei Zhang,Xuyan Gong et al.
Xiaoqiao Xu et al.
Dentin, the primary hard tissue of teeth, is formed through the differentiation of dental mesenchymal progenitor cells into odontoblasts. Primary cilia, essential organelles on the surface of mesenchymal cell populations, are dynamically re...