Bone microarchitecture declines in older men with impaired renal function- the prospective STRAMBO study [0.03%]
肾功能不全老年人骨微结构下降──STRAMBO前瞻性研究
Audrey Bobiller,Danielle Whittier,Laurence Derain Dubourg et al.
Audrey Bobiller et al.
Chronic kidney disease (CKD) may be complicated by mineral and bone disorders (CKD-MBD). Data on the association between estimated glomerular filtration rate (eGFR) and bone microarchitecture are limited. We studied the link between eGFR an...
Inactivating GNAS variants impair GPCR signaling and cause multiple suture craniosynostosis in humans and zebrafish [0.03%]
GNAS基因失活变异通过干扰G蛋白偶联受体信号转导在人和斑马鱼中导致多颅缝早闭症
Qing Yan,Wei Zhou,Han Li et al.
Qing Yan et al.
G protein α-subunit (Gαs), encoded by GNAS, mediates GPCR signaling through cAMP second messenger pathways, and plays a pivotal role in craniofacial morphogenesis and osteoblast differentiation. Craniosynostosis, one of the most prevalent...
Liquid-liquid phase separation in physiological and pathophysiological bone turnover [0.03%]
生理和病理生理骨转换中的液-液相分离现象
Yuxian Xia,Weijian Xu,Xiaofeng Yang et al.
Yuxian Xia et al.
The regulation of bone physiology and pathophysiology is intricately controlled by a complex interplay of cellular and molecular mechanisms. In these processes, the precise spatiotemporal coordination of biological activities in bone-reside...
Gαi1/3 Regulates Wnt/β-Catenin Signaling to Promote Osteogenesis and Bone Formation [0.03%]
Gαi1/3通过调节Wnt/β-连环蛋白信号促进成骨和骨形成
Jinyu Bai,Xueli Qiu,Huajian Shan et al.
Jinyu Bai et al.
Objectives: The Wnt/β-catenin signaling pathway is a classical pathway that regulates bone metabolism. The G protein inhibitory α subunits 1 and 3 (Gαi1/3) can couple with multiple growth factor/cytokine receptors and ...
Vitamin C as an Epigenetic Gatekeeper of Osteogenesis and Skeletal Health - a New Perspective on an Ancient Molecule [0.03%]
维生素C作为骨生成和骨骼健康表观遗传调节因子的新视角——一种古老分子的全新视角
Roman Thaler
Roman Thaler
Vitamin C has been long recognized as an important nutrient for skeletal biology, historically attributed to its role in collagen synthesis and connective tissue integrity. Recent studies, however, reveal vitamin C as a critical epigenetic ...
Hypophosphatasia: Low Penetrance of Pathogenic and Likely-Pathogenic ALPL Variants Identified Through an Unselected Biorepository [0.03%]
低磷血症：通过非选择生物库鉴定的致病和疑似致病ALPL变异的低渗透性
Kathryn M Dahir,Jennifer E Below,Jinyuan Liu et al.
Kathryn M Dahir et al.
Hypophosphatasia (HPP) is a heritable multisystem disorder caused by pathogenic variants in the tissue non-specific alkaline phosphatase (ALP)-coding gene ALPL. The genotype-phenotype correlation in heterozygous adults with HPP remains inco...
Differences and Similarities in Cortical Bone of the Femur between Donors with and without Type 2 Diabetes [0.03%]
有和无2型糖尿病尸体捐献者股骨皮质骨的异同点分析
Emily Berestesky,Sasidhar Uppuganti,Daniel Y Dapaah et al.
Emily Berestesky et al.
For a given bone mineral density, adults with type 2 diabetes (T2D) have greater fracture risk than adults without the disease. To test the hypothesis that T2D lowers the fracture resistance of human cortical bone by negatively altering the...
DXA-derived hip shape is associated with hip fracture: a longitudinal study of 38,123 UK Biobank participants [0.03%]
基于UK生物库中38,123名参与者的纵向研究：源自DEXA的髋部形态与髋部骨折相关性分析
Sophie Scott,Asad Hashmi,Raja Ebsim et al.
Sophie Scott et al.
Despite advancements in fracture prediction tools and osteoporosis management, hip fractures remain a significant consequence of bone fragility, with a 22% one-year mortality. Hip geometric measures (GMs) have been associated with fracture ...
The prevalence of ENPP1 deficiency in humans with OPLL and the preclinical efficacy of ENPP1 enzyme therapy in OPLL mice [0.03%]
人类胸腰椎黄韧带骨化症（OPLL）中ENPP1缺乏的流行率及ENPP1酶治疗对OPLL小鼠的有效性研究
Shivani Srivastava,Hajime Kato,Simon von Kroge et al.
Shivani Srivastava et al.
Ossification of the Posterior Longitudinal Ligament (OPLL) and Diffuse Idiopathic Skeletal Hyperostosis (DISH) are debilitating conditions characterized by pain, stiffness, myelopathy, and impaired mobility due to progressive enthesopathies...
Meslier Q A,Bouxsein M L,E L Scheller
Meslier Q A