ASBMR President's Editorial on the occasion of the 40th anniversary of JBMR [0.03%]
JBMR创刊40周年：ASBMR主席社论
Emma L Duncan
Emma L Duncan
External validation of a novel HR-pQCT based fracture risk assessment tool (FRAC) in a Male Cohort: The Osteoporotic Fractures in Men (MrOS) Study [0.03%]
基于HR-pQCT的骨折风险评估工具（FRAC）在男性队列中的外部验证：老年男性骨质疏松性骨折研究（MrOS）
Annabel R Bugbird,Andrew J Burghardt,Lisa Langsetmo et al.
Annabel R Bugbird et al.
Introduction: Fracture risk estimates can be used clinically to inform treatment decision-making in osteoporosis. Current fracture risk assessment tools have a low sensitivity in predicting fractures in males. This study ...
The clinical utility of imaging in osteoarthritis and its importance in future prediction of total hip replacement; a nested case-control study within the AGES-Reykjavik cohort [0.03%]
用于骨关节炎临床诊治的影像学价值及其对未来髋关节置换术预测的重要性；AGES-雷克雅未克队列中的病例对照研究
Kenneth E S Poole,Ilya S Burkov,Graham M Treece et al.
Kenneth E S Poole et al.
Current guidelines are split on the role that imaging has in the clinical assessment of osteoarthritis, yet clinical computed tomography (CT) imaging has now revealed how a 3D approach can improve prediction of total hip replacement (THR) o...
Functional impact of pathogenic mutations in the Runt homology domain of mouse Runx2 on skeletal and dental phenotypes in cleidocranial dysplasia [0.03%]
基质金属蛋白酶-13通过降解骨形态发生成分6在牙槽嵴顶导致吸收坑的形成
Saki Ogawa,Shinnosuke Higuchi,Yuki Yoshimoto et al.
Saki Ogawa et al.
Runt-related transcription factor 2 (RUNX2) is essential for skeletogenesis, and mutations in its gene cause cleidocranial dysplasia (CCD), an autosomal dominant skeletal disorder. The evolutionarily conserved 128-amino acid Runt homology d...
A RUNX2 GFP reporter is expressed prior to osteochondral differentiation and models Metaphyseal Dysplasia with Maxillary Hypoplasia and Brachydactyly (MDMHB) [0.03%]
RUNX2 GFP報告基因在軟骨膜分化前表達並用作短指及面癱型元片 dysplasia疾病的模型
Dimitrios V Bikas,Sara Vardabasso,Gabrielle Quickstad et al.
Dimitrios V Bikas et al.
SOX9 and RUNX2 are lineage defining transcription factors that drive differentiation of chondrocyte and osteoblast lineages respectively from osteochondral progenitors. In limb development, these progenitors are specified first by SOX9 expr...
Spine age derived from DXA VFA images predicts incident fractures and mortality: the Manitoba Bone Mineral Density Registry [0.03%]
基于DXA VFA图像的脊椎年龄预测骨折和死亡事件：来自马尼托巴骨矿物质密度登记处的数据
Sang Wouk Cho,Namki Hong,Barret A Monchka et al.
Sang Wouk Cho et al.
Biological age may better predict health outcomes than chronological age by capturing individual heterogeneity in aging. We investigated whether accelerated spine aging, estimated from DXA vertebral fracture assessment (VFA) using deep lear...
Activation of the noncanonical inflammasome-GSDMD pathway triggers pyroptosis in bone marrow and promotes periosteal bone formation [0.03%]
骨髓非经典的炎症小体-GSDMD途径活化触发焦亡并促进外膜骨形成
Wei Zou,Chun Wang,Yongjia Li et al.
Wei Zou et al.
Evidence indicating that inflammation is commonly associated with ectopic osteogenesis in certain autoimmune and infectious conditions challenges the dogma that inflammatory responses always suppress bone formation. In this study, we find t...
Associations of Muscle Strength and Functional Power with Longitudinal Change in HR-pQCT Bone Parameters: The Osteoporotic Fractures in Men (MrOS) Study [0.03%]
肌力和功能功率与HR-pQCT骨参数纵向变化的相关性：男性骨质疏松性骨折研究（奥施）
Nina Z Heilmann,Kerri S Freeland,Tong Yu et al.
Nina Z Heilmann et al.
Both bone and muscle function decline with age and are anatomically and functionally related. However, whether and to what extent muscle function (ie, strength and power) may predict longitudinal changes in bone microarchitecture and streng...