Inactivation of Pkd2 in adult mice results in delayed cyst formation and identifies sex as a major modifier of disease severity [0.03%]
Pkd2基因失活小鼠囊肿形成延迟及性别对疾病严重程度影响的鉴定
Patricia Outeda,Perry Summers,Denis Basquin et al.
Patricia Outeda et al.
Introduction: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is caused by mutations in PKD1 or PKD2 and is the most common single-gene disorder resulting in kidney failure. Since deletion of either Pkd1 or Pkd2 in m...
A randomized controlled trial evaluated the effect of pravastatin on kidney disease outcomes in adult patients with early-stage autosomal dominant polycystic kidney disease [0.03%]
一项随机对照试验评估了普伐他汀在成人早期常染色体显性多囊肾病患者中的肾脏结局效应
Berenice Y Gitomer,Anna Ostrow,Wei Wang et al.
Berenice Y Gitomer et al.
Introduction: Whether treatment with pravastatin mitigates kidney dysfunction in adult patients with early autosomal dominant polycystic kidney disease (ADPKD) is unknown. To answer this, we performed a prospective, rando...
Genetic screens of imaging-derived kidney volumes identify genes linked to kidney function [0.03%]
基于影像学的肾脏体积遗传学筛选鉴定出与肾功能相关的基因
Sara Monteiro-Martins,Yong Li,Oleg Borisov et al.
Sara Monteiro-Martins et al.
Introduction: Chronic kidney disease (CKD) is defined as sustained abnormalities in kidney function or structure. Genetic studies of CKD have largely focused on kidney function markers such as estimated glomerular filtrat...
Hierarchical clustering uncovered disease patterns and further untangled complexities in immune complex-mediated idiopathic MPGN and C3 glomerulopathy [0.03%]
层次聚类法揭示了疾病模式，并进一步阐明了以免疫复合物介导的原发性膜增生性肾小球肾炎和C3肾小球病的复杂关系
Ariela Benigni,Erica Daina,Henry Löffler-Wirth et al.
Ariela Benigni et al.
Introduction: Membranoproliferative glomerulonephritis (MPGN) is currently stratified into complement C3 glomerulopathy (C3G) and immune complex-mediated MPGN (IC-MPGN). However, classification is subject to continued deb...
Heterogeneity in the relationships between albuminuria and glomerular structure in type 1 and type 2 diabetes [0.03%]
1型和2型糖尿病中白蛋白尿与肾小球结构关系的异质性研究
Behzad Najafian,Maria Luiza Caramori,Michele Dalla Vestra et al.
Behzad Najafian et al.
Introduction: Kidney structural-functional relationship studies have been critical in understanding diabetic kidney disease (DKD) evolution. However, most such studies were performed in persons with type 1 diabetes, where...
Mono-allelic pathogenic variants in JAG1 cause Autosomal Dominant Tubulo-interstitial Kidney Disease (ADTKD-JAG1) [0.03%]
JAG1单等位基因致病性变异导致常染色体显性遗传性肾小管间质性疾病（ADTKD-JAG1）
Lucie Menguy,Laurent Hudier,Mohamad Zaidan et al.
Lucie Menguy et al.
Introduction: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a common monogenic kidney disease leading to kidney failure usually during mid adulthood. It is due to pathogenic variants in at least five gen...
Syntaxin 3 regulates apical membrane integrity in proximal tubule epithelial cells and prevents Fanconi syndrome development [0.03%]
-syntaxin 3通过调节近端肾小管上皮细胞顶侧膜的完整性来预防范可尼综合征的发展
Hiroki Okushima,Kazunori Inoue,Atsuhiro Imai et al.
Hiroki Okushima et al.
Introduction: Epithelial cell polarity is crucial for the proper functioning of various organs, including the kidneys. Syntaxin 3, a key molecule in membrane-vesicle fusion, is localized in the apical membrane of proximal...
Macrophages mediate acute kidney allograft rejection via a toll-like receptor 4-dependent mechanism [0.03%]
巨噬细胞通过TLR4依赖的方式介导急性肾移植排斥反应
Qixia Shen,Tingting Zhu,Sijing Yan et al.
Qixia Shen et al.
Introduction: Macrophages play an important role in acute renal allograft rejection (RAR). Here we report that macrophages mediate acute RAR via a toll-like receptor 4 (TLR4)-dependent mechanism. ...
Patient anti-PLA2R1 autoantibodies cause membranous nephropathy in human PLA2R1 transgenic mice [0.03%]
人PLA2R1转基因小鼠中患者抗PLA2R1自身抗体引起膜性肾病
Gunther Zahner,Silke Dehde,Larissa Seifert et al.
Gunther Zahner et al.
Introduction: The discovery of anti-phospholipase A2 receptor 1 (PLA2R1) autoantibodies in patients with membranous nephropathy (MN) has led to a paradigm change in diagnosis, monitoring, risk prediction, and therapy of t...
Adeera Levin,Allison Jaure,Dustin J Little et al.
Adeera Levin et al.
Recognizing kidney disease as a major global health issue, the International Society of Nephrology (ISN) convened a two-day international, multi-stakeholder meeting to develop a roadmap for advancing clinical research in nephrology. The mee...