Topical 5-fluorouracil versus photodynamic therapy: differential impact on epidermal clonal mutations in early UV-induced skin carcinogenesis [0.03%]
外用氟尿嘧啶与光动力疗法对早期紫外线诱导皮肤癌前病变表皮克隆突变的不同影响
Gyorgy Paragh,Mitsuko Murakami,Megan E Fitzgerald et al.
Gyorgy Paragh et al.
Éva Ádám,Anita Hajdu,Hodgson Kirsty et al.
Éva Ádám et al.
Spatial Transcriptomics Identifies Cytotoxic and Fibrotic Immune-Stromal Niches in Morphea and Eosinophilic Fasciitis [0.03%]
空间转录组学识别出硬化病和嗜酸细胞性肌炎中的细胞毒性和纤维化免疫-基质生态位
William J Crisler,Kseniia S Anufrieva,Maureen Whittelsey et al.
William J Crisler et al.
Agathe Hercent,Dimitri Tchernitchko
Agathe Hercent
Cutaneous dysbiosis in inherited ichthyoses/epidermal differentiation disorders: a prospective case-control study [0.03%]
针对遗传性鱼鳞病/角化异常的皮肤病原菌失衡：一项前瞻性病例对照研究
Axel Künstner,Ahmed Abdelhamid,Federica Casetti et al.
Axel Künstner et al.
An ITGB4 variant modifies the severity of ITGA3-associated interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa (ILNEB) [0.03%]
ITGB4变异可修改ITGA3相关性间质性肺病、肾病综合征和大疱性表皮松解症（ILNEB）的严重程度
Lubna Gazi Khair,Ofer Sarig,Rawaa Fayez Ishtewy et al.
Lubna Gazi Khair et al.
Biallelic ITGA3 variants cause a rare subtype of junctional epidermolysis bullosa named interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa (ILNEB). ILNEB is characterized by extensive clinical heterogeneity, suggesting...
Selective blockade of γc pathway ameliorates alopecia areata in a humanized murine model [0.03%]
人源化小鼠模型中选择性阻断γc信号通路改善斑秃病症
Wai Chung Wu,Muthu Iswarya Gandhi Sethuraman,Tak Keung Tong et al.
Wai Chung Wu et al.
Alopecia areata (AA) is a chronic autoimmune disease characterized by sudden patchy hair loss and persistent inflammation. To date, only JAK inhibitors have been approved for AA treatment, but FDA-issued black box warnings highlight the nee...
KCTD1/KCTD15 Complexes Repress AP-2α and AP-2β to Regulate Neural Crest-Dependent Craniofacial Morphogenesis and Scalp Skin Development [0.03%]
KCTD1/KCTD15复合体通过抑制AP-2α和AP-2β调节神经嵴依赖的颅面形态建成及头皮皮肤发育
Jackelyn R Raymundo,Bill Senapati,Wenjuan Zhu et al.
Jackelyn R Raymundo et al.
KCTD1 and KCTD15 form pentameric complexes that regulate neural crest cell (NCC) and keratinocyte functions, and dominant-negative mutations in their genes cause aplasia cutis congenita (ACC) and craniofacial abnormalities. Although KCTD1/K...
A global health mandate for skin biology: Research opportunities for improved care after the World Health Assembly (WHA) skin diseases resolution [0.03%]
皮肤病学全球卫生纲领：世界卫生大会(WHA)通过皮肤疾病决议后改善护理的研究机遇
Morvarid Zehtab,Lars E French,Henry W Lim et al.
Morvarid Zehtab et al.
Development and applications of primary human sebocyte-derived sebaceous gland organoids: Sebaceous gland organoids [0.03%]
人源皮脂细胞系来源的皮脂腺类器官体的研发及其应用：皮脂腺类器官体
Si Jia Tan,Cheng Lui Daniel Law,Selwyn Low et al.
Si Jia Tan et al.
Acne vulgaris is one of the most common skin diseases around the world, affecting approximately 9.4% of the global population annually. Cellular and animal-based sebaceous gland models are widely employed to elucidate the pathophysiology an...