Daratumumab as a therapeutic option for rituximab-recalcitrant pemphigus [0.03%]
达雷妥尤单抗可作为利妥昔单抗治疗失败的天疱疮患者的治疗选择
Maud Maho-Vaillant,Alexis Lefebvre,Marie-Laure Golinski et al.
Maud Maho-Vaillant et al.
Rituximab combined with short-term corticosteroids is the standard first-line treatment for pemphigus, but a subset of patients remains refractory, with limited effective alternatives. Daratumumab, an anti-CD38 monoclonal antibody targeting...
Fibroblast-Specific Deletion of Yap/Taz Impairs Mouse Postnatal Dermal Development by Diminishing Collagenous Matrix [0.03%]
Yap/Taz特异性缺失通过减少胶原基质损害小鼠出生后真皮发育
Alexandre N Ermilov,Ava J Kim,Kirk C Hansen et al.
Alexandre N Ermilov et al.
The transcriptional co-activators YAP and TAZ are key regulators of cell proliferation, apoptosis, and differentiation, thereby maintaining tissue homeostasis and controlling organ size. While their roles in epithelial cancers and fibrosis ...
S100A8/A9 Priming Alters Translational Related Proteins and Upregulates Pro-Regenerative Factors in Mesenchymal Stromal Cells [0.03%]
S100A8 / A9 通过改变翻译相关蛋白的表达来启动间充质基质细胞中促再生因子的上调
Yongfang Wang,Albert Kallon Koroma,Karmveer Singh et al.
Yongfang Wang et al.
X-ray Irradiation Suppresses Keloid Growth by Inducing G2/M Arrest via the Phytosphingosine-KIF20A Axis [0.03%]
X射线辐照通过植物鞘氨醇-有丝分裂促进因子KIF20A轴诱导G2/M期阻滞来抑制瘢痕增生
Changyue Wu,Dan Wu,Jianlan Liu et al.
Changyue Wu et al.
Keloid radiotherapy is clinically effective but has an incomplete underlying molecular mechanism and limited accessibility; we used X-ray exposure to identify effector pathways replicating its antifibrotic benefits without further radiation...
IL4I1+ Macrophage Accumulation in Advanced Cutaneous T-Cell Lymphomas Suggests a Role in Tumor Immune Escape [0.03%]
IL4I1+巨噬细胞在晚期皮肤T细胞淋巴瘤中的积聚提示其可能在肿瘤免疫逃逸中发挥作用
Oumeslakht Loubna,Barbara Papouin,C Lamaison et al.
Oumeslakht Loubna et al.
Direct sensitizing and activating effects of interleukin 31 are restricted to a single, functionally and transcriptionally classified porcine DRG neuron subtype [0.03%]
白细胞介素31对功能分类和转录分类的单一种猪背根神经节神经元亚型具有直接致敏和激活作用
Zeinab Abbasi,Marc Behrendt,Sabrina da Silva Soares et al.
Zeinab Abbasi et al.
Interleukin-31 (IL-31) drives chronic pruritus in patients with dermatological and even certain systemic diseases. However, fast-onset anti-pruritic effects of blocking IL-31 receptors, for instance with nemolizumab in atopic dermatitis pat...
Cutibacterium acnes induce T cell extracellular traps with distinct proteome programs [0.03%]
Cutibacterium acnes诱导具有不同蛋白组计划的T细胞胞外陷阱
Thao Tam To,Min Deng,Priscila R Andrade et al.
Thao Tam To et al.
Cutibacterium acnes (C. acnes) is a common skin commensal associated in acne pathogenesis. Here, we investigated whether acne-associated (HL043PA1, CA) and healthy skin-associated (HL110PA3, CH) C. acnes strains differentially induce extrac...
Madison Weber,Amanda Ackermann,Meng-Yen Li et al.
Madison Weber et al.
Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer with a poorly understood cell of origin and initiation process. Most MCC tumors feature monoclonal integration of Merkel cell polyomavirus (MCPyV) DNA, which expr...