Tolga Düz,Daniel Torocsik,Sonia M E Momnougui et al.
Tolga Düz et al.
Single-cell and spatial transcriptomics have transformed the ability to chart human tissue organization at high resolution, enabling the construction of reference atlases and robust gene marker identification. The skin, as the largest human...
Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations [0.03%]
残余CSB活性可解释由CSB突变引起的轻度UV敏感综合征表型
Camila Gonzalo-Hansen,David Häckes,Georgia Avramidou et al.
Camila Gonzalo-Hansen et al.
Transcription-coupled nucleotide excision repair (TC-NER) safeguards transcription by repairing transcription-blocking lesions (TBLs), which are highly cytotoxic if unresolved. TC-NER is triggered when RNA Polymerase II (Pol II) stalls at a...
Charting a new melanoma risk factor: Satellite Naevus Prevalence in High-Risk and Population-Based Cohorts [0.03%]
卫星痣在高危和基于人口队列中的分布图谱：一个新的黑色素瘤风险因素
Nima Ghahari,Lejie Zheng,Preksha Machaiya Kuppanda et al.
Nima Ghahari et al.
Human keratinocytes and fibroblasts coordinate early cutaneous innate defenses against Candida auris [0.03%]
人角质形成细胞和成纤维细胞协调抗铜绿假单胞菌的早期先天性皮肤防御反应
Saskia Seiser,Helena Brezovec,Philipp Penninger et al.
Saskia Seiser et al.
Candida auris (C. auris) is an emerging fungal pathogen with a remarkable ability to persist on human skin, but how structural skin cells respond to colonization is unclear. We used ex vivo human skin models, together with primary keratinoc...
Merkel cells attenuate autoantigen-specific T cell driven skin inflammation in mice associated with reduced neutrophil recruitment [0.03%]
Merkel细胞通过减少中性粒细胞募集来减轻小鼠皮肤自身抗原特异性T细胞介导的炎症
Saeed Shakiba,Isabel Okinedo,Nuha Salam et al.
Saeed Shakiba et al.
Cutaneous lupus erythematosus (CLE) is a lymphocytic interface dermatitis condition that affects the skin and mucosa. Many patients experience photosensitivity and itch. Recent work has demonstrated that Merkel cells in the skin are importa...
The response of human melanocytic nevi to simulated solar radiation assessed by single-nucleus RNA sequencing of frozen tissue [0.03%]
基于冷冻组织的单细胞核RNA测序评估人类黑色素细胞痣对模拟太阳辐射的反应
Pamela B Cassidy,Elizabeth G Berry,Ravikant Samatham et al.
Pamela B Cassidy et al.
Exposure to excess ultraviolet radiation is associated with approximately three-quarters of the global burden of melanoma. Yet, much of what is known about the effects of UV on melanocytes comes from studies of cell lines, animal models, an...
Impact of Online vs In-Person Management of Atopic Dermatitis on Quality of Life and Access to Care: A Randomized Controlled Trial [0.03%]
在线与线下管理特应性皮炎对患者生活质量及就诊途径的影响：一项随机对照试验
April W Armstrong,Alyssa M Roberts,Gina Kostandy et al.
April W Armstrong et al.
Background: Atopic dermatitis (AD) is a chronic skin disease that can significantly affect quality of life and require regular access to dermatologic care. However, traditional in-person visits often impose logistical cha...
Identification of Fibulin-5 as a Granzyme B Substrate Involved in UVB-Induced Elastic Fiber Disruption [0.03%]
鉴定fibulin-5为一种溶细胞素B底物，参与UVB诱导的弹性纤维断裂事件
Hiroko Yamasaki,Misato Yamano,Hirotsugu Kamei et al.
Hiroko Yamasaki et al.
Increased brain activity and connectivity in left middle frontal gyrus in rosacea patients [0.03%]
玫瑰痤疮患者左侧中额回脑活动和功能连接增强
Yiya Zhang,Jiao Yang,Peng Chen et al.
Yiya Zhang et al.
Cellular immunotherapy in psoriasis: Chimeric antigen receptor-based strategies and emerging approaches to immune reset [0.03%]
用于银屑病的细胞免疫治疗：基于嵌合抗原受体的策略及新兴的免疫重置方法
Mingyue Lv,Fengjuan Yang,Chuwen Jiang et al.
Mingyue Lv et al.