Psoriasis-risk SNP rs610604 reveals nuclear IKKα-TNFAIP3 repressor axis driving autoinflammatory circuits [0.03%]
风险SNP(rs610604)揭示了核IKKα-TNFAIP3阻遏轴驱动自身炎症回路
Maria Benedetta Rizzarda Maffezzoni,Francesca Moretti,Elisabetta Botti et al.
Maria Benedetta Rizzarda Maffezzoni et al.
Psoriasis is a chronic inflammatory skin disease characterized by keratinocyte hyperproliferation and immune activation. The single nucleotide polymorphism (SNP) rs610604 within the TNFAIP3 locus is associated with increased psoriasis susce...
B-cell/plasma cell gene co-expression modules enriched in Hidradenitis Suppurativa lesions and tunnels [0.03%]
HS病灶和窦道中富集的B细胞/浆细胞基因共表达模块
Mika Yamanaka-Takaichi,Jaehwan Kim,Ching-Heng Chou et al.
Mika Yamanaka-Takaichi et al.
Updates on endothelial injury in dermatomyositis: Clinical correlations and potential mechanisms [0.03%]
皮肌炎血管病变的临床相关性和潜在机制研究进展
Wenxi Li,Kexin Sun,Junxia Huang et al.
Wenxi Li et al.
Dermatomyositis (DM) is a systemic autoimmune disorder with significant heterogeneity. Recent studies have shown that clinical manifestations associated with vascular damage, such as edema, ulcers, severe capillary microcirculation disturba...
Differential expression of immune checkpoint VISTA in inflammatory skin diseases [0.03%]
免疫检查点VISTA在炎症性皮肤病中的差异表达
Anjali Jaiswal,Eric Kim,Ümmügülsüm Yıldız-Altay et al.
Anjali Jaiswal et al.
Malignant T Cells Operate at the Edge of Redox Tolerance and Propagate Oxidative Stress in Cutaneous T-Cell Lymphoma [0.03%]
恶性T细胞处于红氧耐受的边缘并在皮肤T细胞淋巴瘤中促进氧化应激
Martin R J Namini,Pia R Nielsen,Maria Gluud et al.
Martin R J Namini et al.
Reactive oxygen species (ROS) are tightly regulated in the skin and implicated in both cancer and inflammatory dermatoses, but the role of oxidative stress in cutaneous T-cell lymphoma (CTCL) remains largely unexplored. Here we aim to chara...
Visible Light-Induced Pigmentation: Exploring Variations Across Skin Phototypes and Ancestries [0.03%]
可见光诱导色素沉着：探讨不同皮肤光类型和祖先的差异
Virginie Piffaut,Pascale Renoux,Stéphane Douezan et al.
Virginie Piffaut et al.
Association Between Household Endotoxin Exposure and Atopic Dermatitis: A Cross-Sectional U.S.-Based Population Study [0.03%]
家庭内毒素暴露与特应性皮炎的关联：基于美国的人群横断面研究
Irene Quan,Liza Yusem Carstens,Peter Lio
Irene Quan
Clinical and genetic characterization of genital and inverse psoriasis as a distinct psoriasis endotype [0.03%]
对生殖器和逆向银屑病的临床和基因特征进行描述性研究以确定其作为独立银屑病亚型的证据
Miranda K Chen,Kathryn Haran,Michael J Diaz et al.
Miranda K Chen et al.
Fascia-integrated functional mapping of ion channels promotes scar-tapered repair [0.03%]
筋膜整合的功能图谱促进瘢痕消融修复
Ruiji Guo,Ruoxuan Dai,Yue Lin et al.
Ruiji Guo et al.
Fascia has recently been identified as a primary source of wound fibroblasts and scar tissue in deep wound healing models, highlighting the need to explore fascia-centric mechanisms for regenerative therapy. This study aims to systematicall...
Gut Microbiota Shapes the Effects of Saturated and Polyunsaturated Fatty Acids on Skin and Hair Follicle Homeostasis [0.03%]
肠道微生物群形塑饱和及多元不饱和脂肪酸对皮肤和毛囊稳态的影响
Irina Zhevlakova,Iuliia Molokotina,Amy C Burrows et al.
Irina Zhevlakova et al.
High-fat diets are linked to obesity and skin and hair disorders, yet the role of specific lipid classes remains unclear. Here, we show that cutaneous homeostasis is driven primarily by fatty acid composition rather than total fat content a...