Systemic Inflammation, the Peripheral Blood Transcriptome, and Primary Melanoma [0.03%]
系统性炎症、外周血转录组和原发性黑色素瘤的关系研究
Juliette Randerson-Moor,John Davies,Mark Harland et al.
Juliette Randerson-Moor et al.
Peripheral blood transcriptomes from 383 patients with newly diagnosed melanoma were subjected to differential gene expression analysis. The hypotheses were that impaired systemic immunity is associated with poorer prognosis (thicker tumors...
Vladimir Bezrookove,Sara Kianian,Lea McGeever et al.
Vladimir Bezrookove et al.
The evolution of primary melanoma to lymph node and distant metastasis is incompletely understood. We examined the genomic diversity in melanoma progression in matched primary melanomas and lymph node and distant metastases from 17 patients...
Dermatologists' Perspectives and Usage of Large Language Models in Practice: An Exploratory Survey [0.03%]
皮肤病学家在实践中对大型语言模型的看法和使用情况：一项探索性调查
Haiwen Gui,Shawheen J Rezaei,Daniel Schlessinger et al.
Haiwen Gui et al.
ASH2L Mediates Epidermal Differentiation and Hair Follicle Morphogenesis through H3K4me3 Modification [0.03%]
ASH2L通过H3K4me3修饰介导表皮分化和毛囊形态发生
Qirui Wang,Siyi Zeng,Yimin Liang et al.
Qirui Wang et al.
The processes of epidermal development in mammals are regulated by complex molecular mechanisms, such as histone modifications. Histone H3 lysine K4 methylation mediated by COMPASS (complex of proteins associated with Set1) methyltransferas...
Accelerated Closure of Diabetic Wounds by Efficient Recruitment of Fibroblasts upon Inhibiting a 14-3-3/ROCK Regulatory Axis [0.03%]
通过抑制14-3-3/ROCK调节轴有效募集成纤维细胞加速糖尿病伤口闭合
M Zahied Johan,Natasha T Pyne,Natasha Kolesnikoff et al.
M Zahied Johan et al.
Chronic non-healing wounds negatively impact quality of life and are a significant financial drain on health systems. The risk of infection that exacerbates comorbidities in patients necessitates regular application of wound care. Understan...
Neutrophil-Driven M2-Like Macrophages Are Critical for Skin Fibrosis in a Systemic Sclerosis Model [0.03%]
中性粒细胞诱导的M2型巨噬细胞在系统性硬化症模型皮肤纤维化中的关键作用
Pixia Gong,Yayun Ding,Wen Li et al.
Pixia Gong et al.
Systemic sclerosis (SSc) is a challenging autoimmune disease characterized by progressive fibrosis affecting the skin and internal organs. Despite the known infiltration of macrophages and neutrophils, their precise contributions to SSc pat...
E3 Ubiquitin Ligase NEDD4L Negatively Regulates Skin Tumorigenesis by Inhibiting IL-6/GP130 Signaling Pathway [0.03%]
E3连接酶NEDD4L通过抑制IL-6/GP130信号通路负向调节皮肤肿瘤发生
Huan Liu,Ning Wang,Run Yang et al.
Huan Liu et al.
IL-6 signaling plays a crucial role in the survival and metastasis of skin cancer. NEDD4L acts as a suppressor of IL-6 signaling by targeting GP130 degradation. However, the effects of the NEDD4L-regulated IL-6/GP130 signaling pathway on sk...
Preclinical Atopic Dermatitis Skin in Infants: An Emerging Research Area [0.03%]
婴儿特应性皮炎动物模型皮肤：一个新兴的研究领域
Amy S Paller,Tiffany C Scharschmidt,Sanja Kezic et al.
Amy S Paller et al.
Whereas clinically apparent atopic dermatitis (AD) can be confirmed by validated diagnostic criteria, the preclinical phenotype of infants who eventually develop AD is less well-characterized. Analogous to unaffected or nonlesional skin in ...
The β-Secretase BACE1 Drives Fibroblast Activation in Systemic Sclerosis through the APP/β-Catenin/Notch Signaling Axis [0.03%]
依赖BACE1的淀粉样前体蛋白/β-catenin/诺亦腾信号轴驱动系统性硬化症成纤维细胞活化
Christopher W Wasson,Enrico De Lorenzis,Eva M Clavane et al.
Christopher W Wasson et al.
BACE1 is well-known for its role in the development of Alzheimer's disease. Recent publications, including our own, have demonstrated a role for this enzyme in other chronic diseases. The aim of this study was to investigate the role of BAC...
Dipeptidyl Peptidase-4-Mediated Fibronectin Processing Evokes a Profibrotic Extracellular Matrix [0.03%]
二肽基肽酶-4介导的纤连蛋白加工诱导促纤维化的细胞外基质产生
Karina A Zeyer,Olivier Bornert,Valentin Nelea et al.
Karina A Zeyer et al.
Fibronectin serves as a platform to guide and facilitate deposition of collagen and fibrillin microfibrils. During development of fibrotic diseases, altered fibronectin deposition in the extracellular matrix (ECM) is generally an early even...