Systemic Immune Dysregulation in Neurofibromatosis Type 1: Translational Validation of Atopic Multimorbidity [0.03%]
Liang-Yun Chen,Chung-Ping Liao,Hao-Jui Weng et al.
Liang-Yun Chen et al.
Neurofibromin deficiency drives a pro-inflammatory tumor microenvironment via neuro-immune crosstalk. However, whether this local dysregulation translates into a clinically relevant systemic inflammatory phenotype remains unclear. Using the...
Skin imaging techniques for melanoma detection: A scoping review of modalities, clinical viability, and deployment strategies [0.03%]
Mehdi Boostani,Amanda P Siegel,Abhi Eathara et al.
Mehdi Boostani et al.
Melanoma incidence is rising, whereas access to dermatologists remains limited. In this review, we identified 114 diagnostic-accuracy studies evaluating 11 noninvasive imaging modalities for melanoma detection: photography-based, dermoscopy...
From loci to lesions: An epigenomic framework for translating hidradenitis suppurativa GWAS reveals an epithelial CXCR4-SOX9 disease mechanism [0.03%]
Poppy A Gould,Lynn Petukhova
Poppy A Gould
Evaluation of Itch Intensity Scales in Atopic Dermatitis: Differential Measurement Properties and Associations with Relevant Cytokines [0.03%]
特应性皮炎搔痒强度评分量表的评估：不同测量属性及与相关细胞因子的关系
Felix Witte,Henning Wiegmann,Esther Teitge et al.
Felix Witte et al.
Itch is the cardinal symptom contributing to patient burden in atopic dermatitis (AD). Multiple validated itch scales are used in clinical trials, generating heterogeneous data sets. In addition, recent studies suggest an association betwee...
Creating equitable pathways to close the gap in dermatology workforce representation and skin health for Indigenous Australians [0.03%]
建立公平的途径以缩小土著澳大利亚人在皮肤病学劳动力代表和皮肤健康方面的差距
Dana Slape,Erin McMeniman,Kelvin Kong
Dana Slape
The role of biosimilars in enhancing global access to psoriasis treatment [0.03%]
生物仿制药在增强银屑病治疗全球可及性中的作用
Yasmina Behlock,Sean P Gavan,Thomas Graier et al.
Yasmina Behlock et al.
The introduction of biosimilars for moderate-to-severe psoriasis treatment has demonstrated comparable efficacy and safety to originator biologics, with the potential to improve cost-effectiveness. We explored the potential for biosimilars ...
Mechanotransduction unifies healthy non-diabetic wound healing over time by promoting a Cd14+/C1qa+ fibroblast subpopulation [0.03%]
力学信号转导通过促进Cd14+/C1qa+成纤维细胞亚群的形成在时间上统一健康非糖尿病伤口愈合过程
Katharina S Berryman,Abdelrahman M Alsharif,Mansi Singh et al.
Katharina S Berryman et al.
Diabetes is a major growing public health concern, but the impact on cellular impairments in chronic wounds remains incompletely understood. Fibroblasts, key players in all phases of wound healing, are particularly responsive to mechanotran...
Rabies virus infection and immune activation in human epidermal keratinocytes: Implications for rabies transmission [0.03%]
狂犬病毒感染和人类表皮角质细胞免疫活化：对狂犬病传播的意义
Keshia Kroh,Alisha D Biharie,Eleanor M Marshall et al.
Keshia Kroh et al.
Rabies is a fatal zoonotic infection caused by rabies virus (RABV), which is transmitted through the saliva of infected animals. Although most cases are caused by dog bites, superficial exposures such as bat bites or scratches can also lead...
Mast cell homeostasis depends on KIT ligand from dermal fibroblasts and perivascular cells in mouse skin [0.03%]
小鼠皮肤中 mast 细胞稳态依赖于真皮成纤维细胞和血管周细胞产生的 KIT 配体
Paloma Martzloff,Femke Testroet,Adrian Salatino et al.
Paloma Martzloff et al.
The homeostatic skin represents a tissue niche promoting the survival of several immune cell types. Mast cells (MCs) are resident immune cells distributed throughout the dermal compartment. Their differentiation and survival depend on KIT l...