In Silico Comparison of Rifampicin and 25-desacetyl Rifampicin-Induced PXR-Mediated CYP450 Transcriptional Response in 3D Primary Human Hepatocytes [0.03%]
体外比较利福平和25-脱乙酰基利福平诱导的PXR介导的CYP450转录反应在3D原代人肝细胞中的比较
Ellen Tanaka Kahiya,Tomáš Smutný,Lucie Smutná et al.
Ellen Tanaka Kahiya et al.
The pregnane X receptor (PXR) regulates the expression of cytochrome P450 (CYP) enzymes and plays a crucial role in the metabolism of various drugs. Rifampicin (RIF) is a PXR ligand that forms the primary metabolite, 25-desacetyl rifampicin...
Comparative Study
Bulletin of mathematical biology. 2026 Mar 6;88(4):53. DOI:10.1007/s11538-026-01619-1 2026
Silas Poloni,Frithjof Lutscher,Mark A Lewis
Silas Poloni
Empirical evidence shows that evolution may take place during species' range expansion. Indeed, dispersal ability tends to be selected for at the leading edge of invasions, ultimately increasing a species' spreading speed. However, for orga...
Platelet Adhesion and Aggregation Dynamics over Collagen- and VWF-coated Surfaces: Insights from Dissipative Particle Dynamics Simulations and Microfluidic Experiments [0.03%]
基于 dissipative particle dynamics 模拟和微流控实验的胶原蛋白和VWF表面血小板黏附及聚集动力学研究
Anik Tarafder,Shigang Wang,Yilin Wu et al.
Anik Tarafder et al.
Platelet adhesion and aggregation at sites of vascular injury play a critical role in both physiological hemostasis and pathological thrombosis. Platelets rely on their surface receptors to form bonds with von Willebrand factor (VWF) and ex...
SSRCA: A Novel Machine Learning Pipeline to Perform Sensitivity Analysis for Agent-Based Models [0.03%]
用于代理基础模型灵敏度分析的新型机器学习流水线SSRCA
Edward H Rohr,John T Nardini
Edward H Rohr
Agent-based models (ABMs) are widely used in biology to understand how individual actions scale into emergent population behavior. Modelers employ sensitivity analysis (SA) algorithms to quantify input parameters' impact on model outputs, h...
Eberhard O Voit
Eberhard O Voit
The recent upward trend in the size of mathematical models in the biomedical sciences offers novel opportunities and challenges. The latter are partially technical, for instance, in terms of computational efficiency and the need of vastly i...
Topological Data Analysis for Unsupervised Feature Selection in Large Scale Spatial Omics Data Sets [0.03%]
大规模空间组学数据集的无监督特征选择的拓扑数据分析方法研究
James Boyle,Gregory Hamm,Eleanor Williams et al.
James Boyle et al.
Spatial transcriptomics studies are becoming increasingly large and commonplace, necessitating simultaneous analysis of a large number of spatially resolved variables. Correspondingly, a diverse range of methodologies have been proposed to ...
Pattern Formation in Agent-Based and PDE Models for Evolutionary Games with Payoff-Driven Motion [0.03%]
基于代理和偏微分方程模型的收益驱动运动进化博弈中的图案形成
Tianyong Yao,Chenning Xu,Daniel B Cooney
Tianyong Yao
Spatial structure can play an important role in the evolution of cooperative behavior and the achievement of collective success of a population. In this paper, we explore the role of random and directed motion on spatial pattern formation a...
A Random Differential Equation Approach for Modeling the Growth of Microalgae in Photobioreactors [0.03%]
随机微分方程在光生物反应器中微藻生长建模中的应用
C Andreu-Vilarroig,J-C Cortés,A Navarro-Quiles et al.
C Andreu-Vilarroig et al.
The three-state photosynthetic factory model is frequently employed to analyze microalgal growth in photobioreactors, wherein cells continuously transition between light and dark areas. Experimental data indicate that hydrodynamic mixing re...
Mathematical Modeling of Lesion Pattern Formation in Dendritic Keratitis [0.03%]
树突状角膜炎病变模式形成的数学模型研究
Mari Masunaga,Reo Shimatani,Kazumi Shinozaki et al.
Mari Masunaga et al.
Dendritic keratitis is a form of eye infection caused by herpes simplex virus (HSV). The virus spreads via direct cell-to-cell infection among corneal epithelial cells. This leads to the formation of dendritic lesions characterized by termi...
Modeling and Simulation of the Role of Mass Testing in Controlling COVID-19 [0.03%]
COVID-19 массовое тестирование作用的建模与仿真疫情防控中的作用
Alexandre Maranhão,Marco A Ridenti,André J Chaves
Alexandre Maranhão
This study explores the role of mass testing in controlling the COVID-19 pandemic using an age-stratified compartmental model. The model evaluates the impact of different testing strategies on the pandemic's reproduction number, R 0 , whil...