Bone marrow adipose tissue mass and dipeptidyl peptidase-4 link aging and metabolic health to biomarkers of bone turnover [0.03%]
骨髓脂肪组织和二肽基肽酶与衰老和代谢健康对骨转换生物标志物的影响之间的关联
Sophie Heider,Sabrina Gohlke,Olga Kuxhaus et al.
Sophie Heider et al.
Bone marrow adipose tissue (BMAT) has been linked to negative bone health outcomes and a high level of bone marrow adipocyte accumulation is observed during aging and in individuals with diabetes and obesity. This study explores the relatio...
LXR activation in skeletal muscle cells enhances differentiation and promotes protein synthesis [0.03%]
骨骼肌细胞中活化LXR可增强分化并促进蛋白质合成
Hayataka Takase,Miho Chikazawa,Makoto Noguchi et al.
Hayataka Takase et al.
Skeletal muscle possesses a remarkable capacity for regeneration, which is largely orchestrated by muscle satellite cells (MuSCs), a population of tissue-resident stem cells. Upon injury, these cells sense cues from their niche, transition ...
Beta-cell adaptation to metabolic stresses requires prolactin receptor signaling [0.03%]
泌乳素受体信号传导在胰岛β细胞适应代谢压力中起关键作用
Daniel Lee,Raneet Kahlon,Jingti Deng et al.
Daniel Lee et al.
β-cell adaptation to maternal insulin resistance of pregnancy involves up-regulation of β-cell mass and function, a process we previously showed depends on prolactin receptor (PRLR) signaling. Emering evidence in humans suggests that prol...
Colocalization and functional analyses identify GBE1 as a gene linking muscle strength and cardiometabolic fitness [0.03%]
染色体共定位及功能分析确定GBE1是连接肌肉力量和卡替代谢体质的基因
Theresia M Schnurr,Miranda Lee Johnson,Christopher Jin et al.
Theresia M Schnurr et al.
Handgrip strength is a proxy for muscular fitness, an indicator for general health status, and is associated with cardiometabolic health. The mechanisms connecting handgrip strength to skeletal muscle function are incompletely understood. W...
Exercise Attenuates Polycystic Ovary Syndrome Development via Improved Mitochondrial Proteostasis [0.03%]
运动通过改善线粒体蛋白质稳态抑制多囊卵巢综合征的发展
Chaeyoung Shin,Li-Wei Chen,Md Nazmul Hossain et al.
Chaeyoung Shin et al.
Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder characterized by hyperandrogenism, inflammation, and ovarian dysfunction. While exercise has been recognized as an effective non-pharmacological strategy for managing P...
Semaglutide mitigates the loss of fat-free mass and decreased energy expenditure observed after diet restriction. Insights from an obese minipig model [0.03%]
司美格鲁肽可缓解饮食限制后观察到的脂肪自由基损失和能量消耗下降。来自肥胖迷你猪模型的见解
Simon Krogh Bredum,Julie M Jacobsen,Jens Frey Halling et al.
Simon Krogh Bredum et al.
Objective: To compare the effects of diet restriction and semaglutide treatment on body composition (BC), energy expenditure (EE), and metabolic adaptation (MA) in Göttingen Minipigs as a model for human obesity. ...
Changes in weight and metabolic health during and after cessation of a time-restricted feeding plus aerobic training in Swiss mice fed a high-fat diet [0.03%]
基于高脂饮食的小鼠实施时间限制性采食量结合有氧运动对其体重和代谢健康的影响及其停止后的变化趋势研究
Renan Fudoli Lins Vieira,Susana Castelo Branco Ramos Nakandakari,Gabriel Calheiros Antunes et al.
Renan Fudoli Lins Vieira et al.
Obesity is a chronic disease, representing a significant health problem worldwide. Unhealthy eating habits and sedentarism are key contributors to the development of obesity. Dietary and exercise strategies are the first-line therapies for ...
Jan-Frieder Harmsen,Andries Kalsbeek
Jan-Frieder Harmsen
Glucagon may be extracted across the liver by glucagon-receptor dependent mechanism, and this is impaired in an animal model of fatty liver disease [0.03%]
胰高血糖素可能通过依赖胰高血糖素受体的机制在肝脏中转运，而脂肪肝病动物模型中这种转运作用会受损
Cecilie C N Huynh,Josephine Fisker-Andersen,Richard Kay et al.
Cecilie C N Huynh et al.
Objective: Hyperglucagonemia is a hallmark of metabolic diseases including type 2 diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD), yet the underlying mechanisms are unclear. This study aimed to characterize the...
Impact of obesity on aromatic amino acids and brain glucose during acute hyperglycemia [0.03%]
肥胖对芳香族氨基酸和急性高血糖期间大脑葡萄糖的影响
Brooke C Matson,Felona Gunawan,Douglas L Rothman et al.
Brooke C Matson et al.
Hyperaminoacidemia is an early hallmark of insulin resistance, with aromatic and branched chain amino acids particularly associated with insulin resistance and type 2 diabetes. We previously showed that healthy adults with obesity exposed t...